scholarly journals Histopathological Features of Dental Pulp in Teeth with Different Levels of Chronic Periodontitis Severity

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Elizangela Partata Zuza ◽  
Ana Luiza Vanzato Carrareto ◽  
Raphael Carlos Comelli Lia ◽  
Juliana Rico Pires ◽  
Benedicto Egbert Corrêa de Toledo
Keyword(s):  
Chronic Periodontitis ◽  
Alveolar Bone ◽  
Clinical Attachment Level ◽  
Single Root ◽  
Tooth Apex ◽  
Group 3 ◽  
Group 2 ◽  
Attachment Level ◽  
Different Levels ◽  
Group 1

Purpose. To evaluate the histopathological condition of the pulp in teeth with different levels of chronic periodontitis in humans. Methods. Twenty-five single-root nondecayed teeth were divided into three groups as follows: group 1, clinical attachment level (CAL) 3 to 4 mm and alveolar bone loss (BL) from 4 to 6 mm without reaching the tooth apex; group 2, CAL≥5 mm and BL>6 mm without reaching the tooth apex; group 3, CAL≥5 mm and BL>6 mm up to the tooth apex. Histological analyses were accomplished after laboratorial processing. Results. The mean of CAL was 3.2±0.7 mm in group 1, 7.6±2.0 mm in group 2, and 12.1±2.8 mm in group 3, while for BL it was 4.8±0.9 mm, 7.6±2.2 mm, and 11.9±2.1 mm, respectively. Histopathological data in the pulpal chambers were similar among the three groups showing normal aspects, and, the radicular pulps showed variable levels of reactive dentin, fibrosis, dystrophic mineralizations, atrophy, and mononuclear inflammatory infiltrate. Conclusions. Gradual progression of the chronic periodontitis led to changes in the histopathological aspects of the radicular pulp with progressive involvement.

scholarly journals Clinical and Microbiological Outcomes of Topical Aloe Vera Gel vs. Photochemotherapy as an Adjunct to Non-surgical Periodontal Treatment in Periodontitis

2020 ◽  
Vol 07 (03) ◽  
pp. e100-e105
Author(s):  
Mohamed Farouk Elsadek ◽  
Badreldin Mohamed Ahmed ◽  
Rayan M. Eskandrani ◽  
Tasneem Sobhy Fahmy
Keyword(s):  
Photodynamic Therapy ◽  
Aloe Vera ◽  
Antimicrobial Photodynamic Therapy ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Aloe Vera Gel ◽  
Group 3 ◽  
Group 2 ◽  
Attachment Level ◽  
Group 1

AbstractThe present clinical trial aimed to assess the effectiveness of antimicrobial photodynamic therapy versus Aloe vera gel as an adjunct to scaling and root planing on periodontal and microbial outcomes in patients with periodontitis. Eligible patients undergoing nonsurgical periodontal treatment were divided into 3 groups: group 1: antimicrobial photodynamic therapy; group 2: Aloe vera gel application; and group 3: scaling and root planing only. Clinical periodontal variables included the assessment of plaque scores, bleeding on probing, probing depth, and clinical attachment level gain. Plaque samples were collected to estimate microbial counts of Tannerella forsythia (T. forsythia) and Porphyromonas gingivalis (P. gingivalis). All measurements were recorded at baseline, 3 mo, and 6 mo. Statistical analysis of the given data was performed using the chi-squared test and ANOVA for clinical periodontal and microbiological data. Eighty-seven patients completed the trial. Bleeding on probing showed a significant reduction in group 2 compared with the other groups (p < 0.001). Group 1 showed a statistically significant reduction in probing depth and gain in clinical attachment level when compared to group 2 and group 3 (p < 0.05). Group 1 showed a statistically significant reduction in the counts of T. forsythia and P. gingivalis over a period of 3 mo (p < 0.05). The reduction was seen for T. forsythia only following 6 mo (p < 0.05). Group 2 showed a significant reduction for only T. forsythia at 3 mo (p < 0.05). Both antimicrobial photodynamic therapy and Aloe vera gel helped in reducing periodontal inflammation. Aloe vera gel showed additional benefit in reducing bleeding scores, while antimicrobial photodynamic therapy showed additional enhanced activity against periodontal pathogens and periodontal attachment level gain.

scholarly journals Effect of Scaling and Root Planing on Detection of Tannerella forsythia in Chronic Periodontitis

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Ritesh B. Wadhwani ◽  
Minal S. Chaudhary ◽  
Dipti A. Tharani ◽  
Shweta A. Chandak
Keyword(s):  
Chronic Periodontitis ◽  
Scaling And Root Planing ◽  
Tannerella Forsythia ◽  
Root Planing ◽  
Detection Frequency ◽  
Probing Depth ◽  
Periodontal Destruction ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Aim. This study was aimed to determine the prevalence of Tannerella forsythia in subgingival plaque samples of chronic periodontitis patients having different level of periodontal destruction and to assess the effect of scaling and root planing (SRP) on prevalence of T. forsythia. Materials and Methods. Study included 3 groups: group 1 were healthy individuals, group 2 had periodontitis with probing depth ≤ 5 mm, and group 3 had periodontitis with probing depth > 5 mm. Subjects in groups 2 and 3 exhibited both healthy and diseased periodontal sites. Prevalence of T. forsythia was determined using polymerase chain reaction. Subjects in groups 2 and 3 received SRP and were reevaluated three months after SRP. Results. T. forsythia was not detected in group 1. It was found in diseased sites in 40% and 73.33% of patients from groups 2 and 3, respectively. It was also found in healthy sites in 6.67% and 13.33% of patients from groups 2 and 3, respectively. The detection frequency of T. forsythia after SRP was 6.67% and 13.33% in groups 2 and 3, respectively. Conclusion. The results indicate a possible association between periodontal disease and presence of T. forsythia. Also, the detection frequency of T. forsythia was reduced after SRP.

scholarly journals INFLUENCE OF THE LEVEL MILK PRODUCTIVITY OF MOTHER COWS ON THE GROWTH AND DEVELOPMENT OF HOLSTEIN HEIFERS

2020 ◽  
pp. 165-172
Author(s):  
G.G. Karlikova ◽  
◽  
A.F. Conte ◽  
Keyword(s):  
Comparative Analysis ◽  
Milk Fat ◽  
Growth And Development ◽  
Milk Protein ◽  
Milk Productivity ◽  
Daily Growth ◽  
Group 3 ◽  
Group 2 ◽  
Different Levels ◽  
Group 1

The experiment is carried out on 3 groups of cows (1 - with productivity up to 7500 kg, 2 – from 7500 to 9000 kg and the 3rd group-9000 and above kg of milk for the previous lactation). Milk yield for 305 days of lactation of cows of group 3 averaged 9068 kg (P≤ 0,01), group 2-8682 (P≤ 0,05) and group 1 – 7940 kg of milk. Milk fat production in cows of group 3 - 369 kg (P≤ 0,05), group 2-351 and group 1 – 326 kg. The yield of milk protein from cows of group 3 is 285 kg (P≤ 0,01), group 2-270 (P≤ 0,05) and group 1-248 kg. A comparative analysis of the growth and development of heifers with mothers with different levels of productivity was carried out. At the 2nd month of growing, the weight of heifers of the 3rd group is 76 kg (P≤0,10), the 2nd - 72 kg (P≤0,10). The average daily growth of group 3 heifers at 6 months was 1244 g (P≤0,10), group 2 - 1127 and group 1-617 g.Group 3 Heifers at 9 months weighed 301,2 kg (P≤0,05), group 2 – 299,3 kg (P≤0,05). Heifers of group 3 at 12 months reached 380,6 kg (P≤0,05), group 2–378,5 (P≤0,05) and group 1 – 353,7 kg. The growth of experimental heifers of group 2 was 887,6 g (P≤0,05), group 3–829,6 and group 1 – 710 g per day. Monitoring of growth and development of heifers continues.

scholarly journals The generation of visual inferences in normal elderly Influence of schooling and visual complexity

2010 ◽  
Vol 4 (3) ◽  
pp. 194-201 ◽  
Author(s):  
Ariella Fornachari Ribeiro ◽  
Maria Isabel d'Ávila Freitas ◽  
Márcia Radanovic ◽  
Letícia Lessa Mansur
Keyword(s):  
Visual Complexity ◽  
The Other ◽  
Elderly Subjects ◽  
Healthy Elderly ◽  
Group 3 ◽  
Group 2 ◽  
Level Group ◽  
Different Levels ◽  
Healthy Elderly Subjects ◽  
Group 1

Abstract The generation of inferences makes the construction and comprehension of discourse easier, and integrates representations which add coherence to the arguments. Visuoperceptual and inferential deficits merge in the attempt to explain the difficulties that some individuals have in the comprehension of certain kinds of visual stimuli. Objectives: a) To examine the performance of cognitively healthy elderly subjects in the execution of visual inferences using pictures of different levels of complexity; b) To compare the performance of subjects according to schooling level. Methods: A total of 45 normal elderly aged from 61 to 82yrs (M=68; SD=0.57) were examined. The subjects were divided into three groups according to schooling level: Group 1 (1 to 4 years); Group 2 (5 to 8 years) and Group 3 (9 or more years). Each subject had to create a narrative based on four figures with controlled visual complexity. The narratives were transcribed, analysed and scored. Results: For the essential inferences, the high educated group (3) had a better performance in both visually simple and complex conditions. On the visually complex figures, the medium educated group (2) was statistically equivalent to the high educated group for one figure and equivalent to the less educated group (1) for the other. There was no difference among the groups for the accessory propositions. Conclusions: Visual complexity interferes with the subject's ability to make inferences in low and medium educated individuals. High educated subjects maintain the same performance in making inferences, regardless of the visual complexity level.

scholarly journals Studies on Feeding Effect of Different Levels of Iodine in Salts at Consumption Level

2015 ◽  
pp. 77-85
Author(s):  
AK Obidul Huq ◽  
Md Abu Zubail ◽  
Md Mohiduzzaman ◽  
Nazma Shaheen ◽  
Md Aminul Haque Bhuyan
Keyword(s):  
Urinary Iodine ◽  
Iodine Content ◽  
Consumption Pattern ◽  
Feeding Effect ◽  
Group 3 ◽  
Group 2 ◽  
Almost All ◽  
Different Levels ◽  
Group 1

A prospective cohort study was undertaken to determine the optimum level of iodine in salts at household level which is best suitable to fulfill daily requirements and not excrete too much iodine in urine. A total number of 99 households of 3rd categories and 4th categories employees of Dhaka University, Bangladesh, living in university campus, were randomly divided into 3 groups. A total 778 causal urine samples from 351 individuals of the total households were collected and urinary iodine was estimated by the wet digestion method adapted by Gutekunst et.al. to determine the feeding effect of different levels of iodine in salts. The overall median urinary iodine were 202.7, 196.9 and 238.0 µg/l during baseline study and baseline consumption pattern showed that mean iodine content of salts were 41.6, 34.1 and 36.9 ppm in group-1, group-2 and group-3 respectively. The first follow-up results showed that the overall median urinary iodine were 92.9, 165.2 and 265.6 µg/l and at that time their average iodine content of the experimental salts were 17.5, 27.5 and 45 ppm in group-1, group-2 and group-3 respectively. During first follow-up the majority (72.7%) of the selected population were biochemically iodine deficient in group-1 whereas, almost all (99.1 %) were normal in group-2 and a remarkable fraction of the population (37.9%) excreted excessive urinary ' iodine in group-3. The second follow-up findings indicates the overall median urinary iodine were 156.5, 169.3 and 180.3 µg/l in group-1, group-2 and group-3 respectively and at that time their experimental salt contained same amount of iodine (25-30 ppm). Iodine nutriture status of the study subjects during second follow-up revealed that almost all subjects (97.3%) were normal in group-!, on the other hand, biochemically deficient or excessive excretion of urinary iodine was not observed in group-2 and group-3 i.e. all of the subjects were within the normal range (UI 100-299.99 µg/l) of urinary iodine excretion.

scholarly journals Study of TNF-α, IL-1βand LPS Levels in the Gingival Crevicular Fluid of a Rat Model of Diabetes Mellitus and Periodontitis

2013 ◽  
Vol 34 (5) ◽  
pp. 295-304 ◽  
Author(s):  
Zhu-Ling Jiang ◽  
Yu-Qiong Cui ◽  
Rui Gao ◽  
Ying Li ◽  
Zhao-Chen Fu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Loss ◽  
Alveolar Bone ◽  
Gingival Crevicular Fluid ◽  
Alveolar Bone Loss ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Crevicular Fluid ◽  
Group 1

OBJECTIVE: In this study, we sought to investigate the dynamic changes in the levels of TNF-α, IL-1βand LPS in the gingival crevicular fluid (GCF) in a rat model of diabetes mellitus (DM) and periodontitis (PD). Additionally, we evaluated alveolar bone loss and the histopathological response associated with experimental diabetes mellitus and experimental periodontitis.METHODS: DM and PD were induced together in 15 rats (group 1) by streptozotocin injection and ligature induction. Periodontitis alone was produced by ligature induction in 15 rats (group 2), diabetes alone was produced by streptozotocin injection in 15 rats (group 3), and fifteen systemically and periodontally healthy rats were used as controls (group 4). The gingival TNF-α, IL-1βand LPS levels were measured by using ELISA method. Periodontal destruction was assessed by measuring the alveolar bone loss. Periodontal inflammation was quantified by histopathological grading in H&E stained samples.RESULTS: Higher levels of TNF-α, IL1-β and LPS, increased alveolar bone loss and more serve histopathology were found in group 1 compared with group 2, group 3 and group 4 (p< 0.05). The quantities of TNF-α, IL1-βand LPS, the amount of alveolar bone loss and the severity of the histopathological finding were greater in group 2 than group 3 and group 4 (p< 0.05). Group 3 demonstrated higher levels of TNF-α, IL1-βand LPS, increased alveolar bone loss and more serve histopathology than group 4 (p< 0.05). Statistically significant differences were noted between all of the groups.CONCLUSIONS: These data indicate that DM may lead to enhanced TNF-α, IL1-βand LPS production in the periodontal tissues. The resorption values of alveolar bone and the histological inflammation were more severe in rats with periodontitis and diabetes mellitus than in those with periodontitis alone, diabetes mellitus alone and control rats. Our findings are consistent with the hypothesis that hyperglycemia contributes to the heightened inflammatory response associated with periodontitis.

Quantitative Evaluation of Porphyromonas gingivalis in Indian Subjects With Chronic Periodontitis by Real-Time Polymerase Chain Reaction

2019 ◽  
Vol 10 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Manohar S. Kugaji ◽  
Uday M. Muddapur ◽  
Kishore G. Bhat ◽  
Vinayak M. Joshi ◽  
Vijay M. Kumbar ◽  
...  
Keyword(s):  
Real Time ◽  
Porphyromonas Gingivalis ◽  
Chronic Periodontitis ◽  
Alveolar Bone ◽  
Microbiological Analysis ◽  
Rt Pcr ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Significant Difference ◽  
Attachment Level

Background and Aims: Porphyromonas gingivalis ( P. gingivalis) is considered as an important pathogen responsible for periodontal disease which is characterized by inflammation of gingiva and destruction of periodontal ligament and alveolar bone leading to loss of tooth. Along with clinical investigations, suitable microbiological analysis needs to be performed which could provide more insight into the disease severity. We aim to quantify P. gingivalis by real-time PCR (RT-PCR) and analyze its association with demographic data including clinical parameters. Materials and Methods: The study consisted of chronic periodontitis patients (CP group) and healthy subjects (H group) with 120 samples in each group. RT-PCR was carried out by the SYBR Green assay to target 16S ribosomal ribonucleic acid species-specific region of P. gingivalis. Standard strain of P. gingivalis ATCC 33277 was used as a control. Results: In the CP group, 79.16% samples were found positive for P. gingivalis, whereas 29.17% samples were positive in the H group. A significant difference was found when the prevalence was compared within males and females ( P < .001 for both). In the older age groups, we found a higher rate of detection of P. gingivalis. As analyzed by Spearman’s correlation test, the number of cells of P. gingivalis was significantly associated with probing depth ( P = .02) and clinical attachment level ( P = .01) in the CP group. The mean cell number of P. gingivalis was found to be increasing with increasing levels of probing depth and clinical attachment level ( P < .001 and P = .01, respectively). Conclusion: The present study reaffirms that the P. gingivalis microbe is significantly associated with the chronic periodontitis and that its level varies with the severity of the disease. Colonization of the bacterium is significantly associated with severe forms of the disease.

scholarly journals Examining the Safety and Efficacy of Supplemental Regional Anesthesia After Iliac Crest Harvest During Cleft Alveolar Bone Grafting

FACE ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 66-69
Author(s):  
Robert Lesko ◽  
Srinivas M. Susarla ◽  
Denver Lough ◽  
Anand R. Kumar
Keyword(s):  
Bone Graft ◽  
Pain Score ◽  
Regional Anesthesia ◽  
Iliac Crest ◽  
Alveolar Bone ◽  
Iliac Crest Bone Graft ◽  
Minimal Access ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Background: The optimal prevention and treatment of pain associated of iliac crest bone graft donor sites for the treatment of cleft alveolus defects has not been well characterized. The aim of this study is to assess the efficacy of minimal access bone graft techniques with or without regional anesthesia in iliac crest bone harvest and compare to outcomes to traditional open harvest techniques. Methods: A retrospective review of 46 patients undergoing iliac crest bone harvest using traditional open iliac crest bone graft (ICBG) alone (Group 1, n = 20), minimal access ICBG (Group 2, n = 20), or minimal access ICBG with paravertebral anesthetic block (Group 3, n = 5) was performed. Post operative pain scores, narcotic consumption, and hospital stay were analyzed. Results: The average time to first narcotic was 247 minutes in Group 1, 193 in Group 2, and 1162 minutes in Group 3 ( P < .0002). Total narcotic use was 0.117 mg/kg in Group 1, 0.131 mg/kg in Group 2, and 0.072 mg/kg in Group 3. The average pain score (VAS) was 2.96 in Group 1, 1.83 in Group 2, and 1.08 in Group 3 ( P < .01). The average length of stay was 1.45 for Group 1, 1.36 for Group 2, and 1.0 for Group 3. Bone graft extrusion occurred in 6 patients (27.3%) in Group 1 and none in Group 2 or 3. There were no wound infections, bleeding requiring reoperation, or mortalities. Conclusion: The addition of regional anesthesia to minimal access alveolar bone graft harvest significantly reduces time to first narcotic use. Although not significant, a strong trend was found with regional anesthesia to lower the pain score (VAS) and total narcotic use. Regional anesthesia did not significantly reduce the length of hospital stay compared to either group. Minimal access techniques with supplemental regional anesthesia significantly lowered the pain score and time to first narcotic and trended to decreased length of hospitalization and total narcotic use compared to traditional open techniques.

scholarly journals Comparative study between homeopathy and nimesulide on the prevention of bone resorption in experimental periodontitis in rats.

2010 ◽  
Vol 51 (2) ◽  
pp. 5-8
Author(s):  
Thais Marchini Oliveira ◽  
Bruna Centurion ◽  
Mariana Gigliotti ◽  
Tiago Mergulhão ◽  
Vivien Sakai ◽  
...  
Keyword(s):  
Bone Loss ◽  
Saline Solution ◽  
Alveolar Bone ◽  
Microscopic Analysis ◽  
Alveolar Bone Loss ◽  
Light Microscopic Analysis ◽  
Group 3 ◽  
Group 2 ◽  
Inflammatory Changes ◽  
Group 1

Periodontitis is a chronic disease characterized by bone loss and inflammatory changes. We studied the effect of a homeopathic agent (Mercúrios Corrosivos 6 CH) and a non-steroidal anti-inflammatory drug (nimesulide) on the alveolar bone loss progression in experimentally induced periodontitis in rats. Sixty (60) Wistar rats were separated into group 1 (homeopathy), group 2 (nimesulide) and group 3 (saline solution). Silk ligatures were placed at the gingival margin level of the lower right first molar of all rats. Alveolar bone loss was evaluated by light microscopic analysis and analyzed using software Image J. The results were submitted to the analysis of variance (ANOVA) and Tukey’s posttest (p

scholarly journals Effect of Non Surgical Periodontal Therapy on Gingival Crevicular Fluid and Serum Visfatin Concentration in Periodontal Health and Disease

2012 ◽  
Vol 32 (6) ◽  
pp. 383-388 ◽  
Author(s):  
N.M. Raghavendra ◽  
A.R. Pradeep ◽  
Rahul Kathariya ◽  
Anuj Sharma ◽  
Nishanth S. Rao ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Inflammatory Marker ◽  
Periodontal Therapy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Samples ◽  
Group 3 ◽  
Group 2 ◽  
Crevicular Fluid ◽  
Group 1

Visfatin is a pleiotropic mediator which acts as growth factor, cytokine, enzyme involved in energy including nicotinamide adenine dinucleotide metabolism and has been recently demonstrated to exert several pro-inflammatory functions. The purpose of this study is to evaluate the Visfatin concentration in gingival crevicular fluid (GCF) and serum in patients with chronic periodontitis, and to evaluate the effect of non-surgical periodontal therapy on the GCF and serum visfatin concentration. 30 subjects (age range: 25 to 52 years) were selected and divided into two groups based on the gingival index, probing depth, periodontal attachment level, and radiologic parameters (bone loss): group 1 (15 subjects with healthy periodontium), group 2 (15 subjects with chronic periodontitis), while, Group 2 patients after 8 weeks of the treatment (scaling and root planning, SRP) constituted group 3. GCF samples (by microcapillary pipettes) and serum samples (by venipuncture) were collected to estimate the levels of Visfatin using enzyme linked immunosorbent assay kit. The mean Visfatin concentration in GCF and serum was observed to be the highest in group 2 and lowest in group 1. While concentration in group 3 was similar to group 1. The concentration of Visfatin in GCF and serum decreased after SRP. The Visfatin concentration in GCF and serum found to be highest in chronic periodontitis group and decreases after treatment. Hence Visfatin values can be considered as an “inflammatory marker” can be explored in future as a potential therapeutic target in the treatment of periodontal disease.

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