scholarly journals Modeling Transport and Flow Regulatory Mechanisms of the Kidney

2012 ◽  
Vol 2012 ◽  
pp. 1-18 ◽  
Author(s):  
Anita T. Layton
Keyword(s):  
Tubuloglomerular Feedback ◽  
Regulatory Mechanisms ◽  
Electrolyte Balance ◽  
Acid Base Balance ◽  
Acid Base ◽  
Kidney Physiology ◽  
Base Balance ◽  
Modeling Transport ◽  
Health And Disease ◽  
Renal Oxygen

The kidney plays an indispensable role in the regulation of whole-organism water balance, electrolyte balance, and acid-base balance, and in the excretion of metabolic wastes and toxins. In this paper, we review representative mathematical models that have been developed to better understand kidney physiology and pathophysiology, including the regulation of glomerular filtration, the regulation of renal blood flow by means of the tubuloglomerular feedback mechanisms and of the myogenic mechanism, the urine concentrating mechanism, and regulation of renal oxygen transport. We discuss how such modeling efforts have significantly expanded our understanding of renal function in both health and disease.

Acid-base balance and plasma composition in the aestivating lungfish (Protopterus)

1977 ◽  
Vol 232 (1) ◽  
pp. R10-R17 ◽  
Author(s):  
R. G. DeLaney ◽  
S. Lahiri ◽  
R. Hamilton ◽  
P. Fishman
Keyword(s):  
Plasma Osmolality ◽  
Respiratory Acidosis ◽  
Electrolyte Balance ◽  
Plasma Composition ◽  
Total Plasma ◽  
Acid Base Balance ◽  
Acid Base ◽  
Plasma Bicarbonate ◽  
Arterial Ph ◽  
Base Balance

Upon entering into aestivation, Protopterus aethiopicus develops a respiratory acidosis. A slow compensatory increase in plasma bicarbonate suffices only to partially restore arterial pH toward normal. The cessation of water intake from the start of aestivation results in hemoconcentration and marked oliguria. The concentrations of most plasma constituents continue to increase progressively, and the electrolyte ratios change. The increase in urea concentration is disproportionately high for the degree of dehydration and constitutes an increasing fraction of total plasma osmolality. Acid-base and electrolyte balance do not reach a new equilibrium within 1 yr in the cocoon.

scholarly journals Extracellular Acid-Base Balance and Ion Transport Between Body Fluid Compartments

Physiology ◽  
2017 ◽  
Vol 32 (5) ◽  
pp. 367-379 ◽  
Author(s):  
Julian L. Seifter ◽  
Hsin-Yun Chang
Keyword(s):  
Ion Transport ◽  
Ph Regulation ◽  
Extracellular Fluid ◽  
Transport Processes ◽  
Electrolyte Balance ◽  
Ph Homeostasis ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance ◽  
Fluid Compartments

Clinical assessment of acid-base disorders depends on measurements made in the blood, part of the extracellular compartment. Yet much of the metabolic importance of these disorders concerns intracellular events. Intracellular and interstitial compartment acid-base balance is complex and heterogeneous. This review considers the determinants of the extracellular fluid pH related to the ion transport processes at the interface of cells and the interstitial fluid, and between epithelial cells lining the transcellular contents of the gastrointestinal and urinary tracts that open to the external environment. The generation of acid-base disorders and the associated disruption of electrolyte balance are considered in the context of these membrane transporters. This review suggests a process of internal and external balance for pH regulation, similar to that of potassium. The role of secretory gastrointestinal epithelia and renal epithelia with respect to normal pH homeostasis and clinical disorders are considered. Electroneutrality of electrolytes in the ECF is discussed in the context of reciprocal changes in Cl−or non Cl−anions and [Formula: see text].

scholarly journals Effect of Simulated Matches on Post-Exercise Biochemical Parameters in Women’s Indoor and Beach Handball

2020 ◽  
Vol 17 (14) ◽  
pp. 5046
Author(s):  
Joanna Kamińska ◽  
Tomasz Podgórski ◽  
Jakub Kryściak ◽  
Maciej Pawlak
Keyword(s):  
Blood Parameters ◽  
Ion Concentration ◽  
Electrolyte Balance ◽  
Acid Base Balance ◽  
Acid Base ◽  
Urine Ph ◽  
Physically Active ◽  
Post Exercise ◽  
Before And After ◽  
Base Balance

This study assesses the status of hydration and the acid-base balance in female handball players in the Polish Second League before and after simulated matches in both indoor (hall) and beach (outdoor) conditions. The values of biochemical indicators useful for describing water-electrolyte management, such as osmolality, hematocrit, aldosterone, sodium, potassium, calcium, chloride and magnesium, were determined in the players’ fingertip capillary blood. Furthermore, the blood parameters of the acid-base balance were analysed, including pH, standard base excess, lactate and bicarbonate ion concentration. Additionally, the pH and specific gravity of the players’ urine were determined. The level of significance was set at p < 0.05. It was found that both indoor and beach simulated matches caused post-exercise changes in the biochemical profiles of the players’ blood and urine in terms of water-electrolyte and acid-base balance. Interestingly, the location of a simulated match (indoors vs. beach) had a statistically significant effect on only two of the parameters measured post-exercise: concentration of calcium ions (lower indoors) and urine pH (lower on the beach). A single simulated game, regardless of its location, directly affected the acid-base balance and, to a smaller extent, the water-electrolyte balance, depending mostly on the time spent physically active during the match.

Endocrine and metabolic emergencies

2016 ◽  
Keyword(s):  
Adrenal Gland ◽  
Glucose Control ◽  
Metabolic Disorders ◽  
Electrolyte Balance ◽  
Acid Base Balance ◽  
Acid Base ◽  
Nursing Assessment ◽  
Base Balance

This chapter covers common metabolic disorders, principally disorders of glucose control, acid–base balance, and electrolyte balance. The nursing assessment and management of thyroid and adrenal gland emergencies are also covered.

scholarly journals Different sources of sulfur in diets of adult cats on the urinary parameters and acid-base balance

2018 ◽  
Vol 48 (10) ◽  
Author(s):  
Dóris Pereira Halfen ◽  
Alexandre de Mello Kessler ◽  
Luciano Trevizan ◽  
Juliana Toloi Jeremias ◽  
Thiago Henrique Annibale Vendramini ◽  
...  
Keyword(s):  
Calcium Sulfate ◽  
Control Diet ◽  
Electrolyte Balance ◽  
Acid Base Balance ◽  
Acid Base ◽  
Urinary Ph ◽  
Base Balance ◽  
Adult Cats ◽  
Urinary Parameters ◽  
Different Sources

ABSTRACT: Urolithiasis is a common disorder in the veterinary clinic and is considered as one of the most frequently cause of morbidity. This disorder is closely associated with urinary pH and nutrition plays a key role in the control of this disease, because through dietary manipulation it is possible to modify the urinary pH. Sulfur is considered macroelement with a strong influence on the acid-base status and may be crucial to control urinary pH in cats. The purpose of this study was to evaluate the effects of addition of different sources of sulfur (S) in the diet of cats on the urinary parameters and acid-base balance. Forty-two healthy adult cats were divided into 3 groups, and each group of 14 cats received 7 diets in a complete randomized block design. Calcium sulfate (CaSO4), DL-methionine (DLM) and methionine hydroxy analog (MHA) were added to a control diet in two levels (1.28g S/kg and 2.56g S/kg) to formulate 6 other experimental diets. The acid-base balance was evaluated by hemogasometry in samples of venous blood. The DLM at the highest level and MHA differed of the control diet in relation to urinary pH (P<0.05). Calcium sulfate; although, not differentiated from the control diet, has been shown to alter urinary pH despite its zero electrolyte balance. Apparently, the alkalizing effect of calcium was not sufficient to avoid sulfate acidification of the urine. Treatments showed no alteration of the acid-base balance of the animals and no affect the consumption of the diets.

scholarly journals Post craniotomy and electrocardiographic monitoring

2021 ◽  
Vol 10 (1) ◽  
pp. 40
Author(s):  
Hendy Lesmana ◽  
Ahmat Pujianto ◽  
Bayu Purnomo
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Heart Rhythm ◽  
Electrolyte Balance ◽  
Acid Base Balance ◽  
Acid Base ◽  
Sinus Arrhythmia ◽  
Balance Disorders ◽  
Electrocardiographic Monitoring ◽  
Base Balance

Background: Post craniotomy management mainly emphasizes monitoring complications that occur. Close supervision and monitoring are needed in post craniotomy patients, especially in the first 48 hours so that the patient is placed in the intensive care unit (ICU). Various studies have identified various complications that arise from mild complications to severe complications, namely the death of patients after craniotomy, so that hemodynamic monitoring tool are needed. Electrocardiography is one of the hemodynamic monitoring tools in the intensive care room which is very useful in monitoring heart rhythm abnormalities in post-craniotomy patients.Methods: This descriptive study was conducted on 30 respondents post craniotomy and were treated in the Intensive Care Unit (ICU) for 1-3 days of treatment. An electrocardiographic monitoring analysis was performed on 30 respondents, then confirmed by examination of blood electrolytes and blood gas analysis.Results: In this study 90% of respondents experienced electrocardiographic rhythm abnormalities, 50% sinus arrhythmia, 33.3% sinus tachycardia, 6.7% sinus bardycardia. The results of electrolyte examination 18 respondents experienced electrolyte balance disorders where 4 respondents experienced hyponatremia, 7 respondents experienced hypernatremia+hyperchloremia, 1 respondent experienced hyponatremia+hypochloremia, 5 respondents experienced hyperchloremia and 1 respondent experienced hypokalemia. There are 7 respondents experiencing acid-base balance disorders.Conclusions: in this study showed that most of the patients after craniotomy had heart rhythm abnormalities. The most common arrhythmia is sinus arrhythmia. The pathological conditions that accompany these rhythm disturbances are mostly caused by electrolyte balance disorders, acid-base balance disorders or a combination of the two disorders.

Fluid and electrolyte balance and replacement: acid–base balance

2016 ◽  
pp. 57-63
Author(s):  
David A. Fordham ◽  
Catriona Kelly ◽  
Rosalind O’ Reilly ◽  
Brian Mullan
Keyword(s):  
Electrolyte Balance ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

Kidneys and chronic renal disease

2018 ◽  
Author(s):  
Hugh Devlin ◽  
Rebecca Craven
Keyword(s):  
Renal Disease ◽  
Chronic Renal Disease ◽  
Clinical Implications ◽  
Electrolyte Balance ◽  
Bleeding Tendency ◽  
Acid Base Balance ◽  
Bone Pathology ◽  
Acid Base ◽  
Base Balance ◽  
And Function

Kidneys and chronic renal disease in relation to dentistry is the topic of this chapter. The chapter starts with the structure and function of the kidneys. The functions of acid-base balance and electrolyte balance are described. Chronic renal disease/failure (CRD/CRF) is then considered in terms of its impact on drug metabolism and excretion, anaemia, and bone pathology. Finally, the bleeding tendency associated with chronic renal failure is discussed, together with its clinical implications.

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