scholarly journals Short-Term Therapy with Rosiglitazone, a PPAR-γ Agonist, Improves Metabolic Profile and Vascular Function in Nonobese Lean Wistar Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Mohammad M. Naderali ◽  
Imose Itua ◽  
Abdul-Razak Abubakari ◽  
Ebrahim K. Naderali
Keyword(s):  
Blood Pressure ◽  
Vascular Function ◽  
Metabolic Profile ◽  
Wistar Rats ◽  
Term Therapy ◽  
Control Group ◽  
No Production ◽  
Blood Pressure Lowering ◽  
Short Term ◽  
Pressure Lowering

A number of preclinical and clinical studies have reported blood-pressure-lowering benefits of thiazolidinediones in diabetic subjects and animal models of diabetes. This study was designed to further elucidate vascular effects of rosiglitazone, on healthy nonobese, lean animals. Adult male Wistar rats were randomized and assigned to control and rosiglitazone-treated groups and were dosed daily with either vehicle or rosiglitazone (10 mg kg−1 day−1) by oral gavage for 5 days. Compared with control group, rosiglitazone treatment significantly reduced plasma levels of triglycerides (>240%) and nonesterified free fatty acids (>268%) (both, P<0.001). There were no changes in vascular contractility to KCl or noradrenaline between two groups. However, rosiglitazone therapy improved carbamylcholine-induced vasorelaxation (93±3 % versus control 78±2, P<0.01) an effect which was abolished by L-NAME. There was no difference in sodium nitroprusside-induced vasorelaxation between the control and rosiglitazone-treated animals. These results indicate that short-term rosiglitazone therapy improves both metabolic profile and vascular function in lean rats. The vascular effect of rosiglitazone appears to be mediated by alteration in NO production possibly by activation of endothelial PPARγ. This increased NO production together with improved lipid profile may explain mechanism(s) of blood-pressure-lowering effects of thiazolidinediones on both human and experimental animals.

scholarly journals BLOOD PRESSURE LOWERING EFFECT OF POLYHERBAL PREPARATION CONTAINING ALLIUM SATIVUM, BELERICAE FRUCTUS, CURCUMA AERUGINOSA, AND AMOMI FRUCTUS ON RAT MODEL OF HYPERTENSION

2019 ◽  
pp. 311-314 ◽  
Author(s):  
DWI ARIS AGUNG NUGRAHANINGSIH ◽  
SHOLIKHAH EN ◽  
MUSTOFA M ◽  
YULIANI FS ◽  
PURWONO S ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Rat Model ◽  
Allium Sativum ◽  
Negative Control ◽  
Control Group ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Treatment Dose ◽  
Pressure Lowering

Objective: The study aimed to investigate the blood pressure lowering effect of the polyherbal preparation contains Allium sativum, Belericae fructus, Curcuma aeruginosa, and Amomi fructus in the animal model of hypertension. Methods: Deoxycorticosterone acetate uninephrectomy salt rat model was used to develop hypertension model. Hypertensive rats were divided into five groups that were no treatment (negative control group [NEG]), hydrochlorothiazide treatment, polyherbal preparation 63 mg/kg treatment (DOSE 1), polyherbal preparation 126 mg/kg treatment (DOSE 2), and polyherbal preparation 252 mg/kg treatment (DOSE 3). The treatment was started after hypertension developed and given for 3 weeks. Results: The result showed that the mean of systolic blood pressure in DOSE 2 group was significantly lower compared with those on NEG group (145.86 mmHg vs. 174.71 mmHg, p<0.05). Conclusion: Our study provides evidence to support the use of the polyherbal preparation containing A. sativum, B. fructus, C. aeruginosa, and A. fructus for lowering blood pressure.

The Organization of a Multi-Centre Randomized Control Therapeutic Trial for Mild to Moderate Hypertension

1973 ◽  
Vol 45 (s1) ◽  
pp. 67s-70s
Author(s):  
W. S. Peart
Keyword(s):  
Myocardial Infarction ◽  
Blood Pressure ◽  
Moderate Hypertension ◽  
Mild Hypertension ◽  
Treated Group ◽  
Control Group ◽  
Therapeutic Trial ◽  
Blood Pressure Lowering ◽  
Pressure Lowering ◽  
Randomized Control

1. The organization of a multi-centre randomized therapeutic trial for mild hypertension is described. 2. Particular attention will be paid to the effect of blood pressure lowering on susceptibility to myocardial infarction. 3. It is calculated that screening of around 180 000 subjects will be required, and that approx. 9000 men and 9000 women will eventually enter the treated group, and a similar number be randomly allocated to the control group. 4. Two separate hypotensive drugs, with different modes of action, will be employed in the treated group.

PENGARUH PIJAT KAKI TERHADAP PENURUNAN TEKANAN DARAH PADA IBU HAMIL DENGAN HIPERTENSI DI RS YOGYAKARTA

2019 ◽  
Vol 8 (1) ◽  
pp. 77-86
Author(s):  
Retno Mawarti ◽  
Lailatuz Zaidah
Keyword(s):  
Blood Pressure ◽  
Essential Oil ◽  
Pregnant Women ◽  
Control Group ◽  
Blood Pressure Lowering ◽  
Hypertension In Pregnancy ◽  
Blood Pressure Difference ◽  
Before And After ◽  
Pressure Lowering ◽  
In Pregnancy

Background: Hypertension in pregnancy is a disease that gets attention given the negative effects it has on both the mother and the fetus. Hypertension in pregnancy if not treated properly will develop into superimposed Preeclampsia along with the increase in gestational age. Massage with aromatherapy oil is a non-pharmacological therapy to reduce and maintain blood pressure in a range that can be tolerated by the body. Objective: This study aims to determine the effect of a foot massage with lavender essential oil on reducing blood pressure in pregnant women with hypertension. Methods: The methodology used in this study was pre-experimental with the control group. Respondents consist of 15 pregnant women with hypertension who had been given blood pressure-lowering therapy, 8 people performed foot massage and 7 people made the control with accidental sampling technique. Massage with lavender essential oil conducted for 15-20 minutes every day for 7 days. Data were obtained by measuring blood pressure before and after the intervention, and then recorded into the observation sheet. The control group performed pressure measurements before and after given by blood pressure-lowering drugs, then analyzed by descriptive and bivariate statistical tests. Results: The results showed that the blood pressure difference before and after systole intervention was 6,52, diastole 0.82 in the control group of blood pressure difference before and after being given systole drug 7,902 diastole 4,847 Paired t-test results in the systole intervention group 0.340, diastole 0.40 and in the systole control group 0.068, diastole 0.137 (p = 0.05). Conclusion: The conclusion is the effect of a foot massage with lavender essential oil in pregnant women with hypertension. Suggestions for pregnant women with primary hypertension should do foot massage to help lower blood pressure. Keywords: Aromatherapy, foot massage, hipertension, lavender, pregnancy.

scholarly journals Blood pressure lowering effect of Pennisetum glaucum in rats

2015 ◽  
Vol 10 (3) ◽  
pp. 494
Author(s):  
Muhammad Naveed Mushtaq ◽  
Muhammad Shoaib Akhtar ◽  
Alamgeer .
Keyword(s):  
Blood Pressure ◽  
Methanolic Extract ◽  
Pennisetum Glaucum ◽  
Invasive Technique ◽  
Maximum Effect ◽  
Control Group ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Pressure Lowering

<p>The present study was carried out to evaluate the seeds of Pennisetum glaucum for its blood pressure lowering effect in rats. Aqueous-methanolic extract of P. glaucum seeds in 250, 500 and 1000 mg/kg doses was studied in normotensive, egg-feed diet and glucose-induced hypertensive rats using non-invasive technique. The extract significantly (p˂0.5 - p˂0.001) decreased blood pressure and heart rate with maximum effect at 1,000 mg/kg dose. The extract was found to prevent rise in blood pressure of egg and glucose fed rats as compared to control group in 21 days study. The extract was safe in mice up to dose of 4 g/kg and sub-chronic toxicity study showed that there was no significant alterations in blood chemistry of extract treated rats. It is conceivable, therefore, that aqueous-methanolic extract of P. glaucum seeds has exerted considerable antihypertensive activity which may be due to the presence of phytochemical constituents.</p><p> </p>

scholarly journals PENGARUH PIJAT KAKI TERHADAP PENURUNAN TEKANAN DARAH PADA IBU HAMIL DENGAN HIPERTENSI DI RS YOGYAKARTA

2019 ◽  
Vol 8 (1) ◽  
pp. 77-86
Author(s):  
Retno Mawarti ◽  
Lailatuz Zaidah
Keyword(s):  
Blood Pressure ◽  
Essential Oil ◽  
Pregnant Women ◽  
Control Group ◽  
Blood Pressure Lowering ◽  
Hypertension In Pregnancy ◽  
Blood Pressure Difference ◽  
Before And After ◽  
Pressure Lowering ◽  
In Pregnancy

Background: Hypertension in pregnancy is a disease that gets attention given the negative effects it has on both the mother and the fetus. Hypertension in pregnancy if not treated properly will develop into superimposed Preeclampsia along with the increase in gestational age. Massage with aromatherapy oil is a non-pharmacological therapy to reduce and maintain blood pressure in a range that can be tolerated by the body. Objective: This study aims to determine the effect of a foot massage with lavender essential oil on reducing blood pressure in pregnant women with hypertension. Methods: The methodology used in this study was pre-experimental with the control group. Respondents consist of 15 pregnant women with hypertension who had been given blood pressure-lowering therapy, 8 people performed foot massage and 7 people made the control with accidental sampling technique. Massage with lavender essential oil conducted for 15-20 minutes every day for 7 days. Data were obtained by measuring blood pressure before and after the intervention, and then recorded into the observation sheet. The control group performed pressure measurements before and after given by blood pressure-lowering drugs, then analyzed by descriptive and bivariate statistical tests. Results: The results showed that the blood pressure difference before and after systole intervention was 6,52, diastole 0.82 in the control group of blood pressure difference before and after being given systole drug 7,902 diastole 4,847 Paired t-test results in the systole intervention group 0.340, diastole 0.40 and in the systole control group 0.068, diastole 0.137 (p = 0.05). Conclusion: The conclusion is the effect of a foot massage with lavender essential oil in pregnant women with hypertension. Suggestions for pregnant women with primary hypertension should do foot massage to help lower blood pressure. Keywords: Aromatherapy, foot massage,hipertension,  lavender, pregnancy.

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