scholarly journals The Prevalence of Giardia Intestinalis in Dyspeptic and Diabetic Patients

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Gözde Derviş Hakim ◽  
Şafak Kızıltaş ◽  
Hilmi Çiftçi ◽  
Şafak Göktaş ◽  
İlyas Tuncer
Keyword(s):  
Diabetes Mellitus ◽  
Giardia Intestinalis ◽  
Diabetic Patients ◽  
Elisa Method ◽  
Number Of Patients ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Stool Specimens ◽  
Positive Results ◽  
Healthy Persons

Background and Aims. We aimed to investigate the prevalence of Giardiasis in patients with dyspepsia and patients with diabetes mellitus. Methods. 400 patients and 100 healthy persons were included in this clinical prospective study. The number of patients in each group was equal, 200 dyspeptic and 200 diabetic, respectively. The antigen of G. lntestinalis was determined in the stool specimens by ELISA method. Results. The frequency of Giardiasis was 7% in dyspeptic and 15% in diabetic patients. There was no positive results in any of the healthy persons. There was a significant difference in prevalence rate of Giardiasis between patients with dyspepsia and diabetes mellitus (P<0.05). Conclusions. These results revealed that the prevalence of Giardiasis in dyspepsia and with diabetes mellitus was high in our country. This is the first study investigating the prevalence of Giardiasis in diabetic patients. To investigate Giardiasis in diabetic patients, who have dyspepsia or not, may be a good approach for public health.

scholarly journals Peculiarities of Physical Activity and Self‑Esteem of Young People with Diabetes Mellitus Type 1 and Healthy Persons Aged 18–25 Years

2018 ◽  
Vol 4 (83) ◽  
Author(s):  
Sandrija Čapkauskienė ◽  
Daiva Vizbaraitė ◽  
Deimantė Šeštokaitė
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Healthy Subjects ◽  
Self Esteem ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Diabetic Patients ◽  
Patients With Diabetes ◽  
Healthy Persons

Research background and hypothesis. Careful diabetes control slows the onset and progression of life-threatening complications, the development of disability and early disability-related unemployment, and prolongs life expectancy (Danytė et al., 2000). The benefits of physical activity on regular basis comprise improved cardiovascular health, increased  lean body mass, improved  blood lipid profile, enhanced  psycho-social wellbeing and decreased obesity  (Riddell, Iscoe, 2006). Physical activity is one of the main factors influencing glucose level in diabetic patients’ blood (Wiśniewski, 2010). Analysis of self-esteem of the studied revealed a wide range of findings, from trying to outline the modest achievements, pride, and even unwillingness to discuss it to low self-esteem, feeling of guilt and self-reproach for mistakes and failures (Žemaitis, 1995). The aim of the study was to determine physical activity and self-esteem of healthy subjects and patients with diabetes mellitus type 1 aged 18–25 years.Methods. The  study  included  140  individuals  (aged  from  18  to  25  years). Among  41  patients  with  type  1 diabetes mellitus there were 33 young women and 8 young men, and among 99 healthy persons – 79 young women and  29 young men. All the subjects were asked to fill in the questionnaire orientated to physical activity and self-esteem. The short IPAQ questionnaire was used to research physical activity and Rosenberg’s Self-Esteem Scale was used to assess self esteem.Research results. Approximately 60% of subjects with  diabetes mellitus type 1 and about 50% of healthy persons rated their physical activity as moderate. Intensive 60-minute-physical activity was reported by 48.5% of healthy subjects and 34.1% of diabetic patients, moderate 60-minute-physical activity was pointed out by 38.2% of diabetic patients and 35.8% of healthy research participants. The largest walking interval was 1–1.5 hours: in the diabetic group– 28.8%, in the healthy group – 31.65%. Healthy young men and women were physically more active than diabetic patients. Self-esteem in both genders of healthy subjects and diabetic patients was determined as moderate.Discussion and conclusions. Physical activity of women and men with diabetes mellitus type 1 aged 18–25 years was valued as moderate, meanwhile physical activity in healthy persons – moderate or high. Self-esteem is moderate in both groups of patients with diabetes and healthy persons. Healthy men are more active than diabetic patients, similarly, women having diabetes mellitus type 1 are more physically passive than healthy ones. Both patients with diabetes mellitus type 1 and healthy individuals aged 18–25 reported moderate self-esteem.Keywords: diabetes mellitus type 1, physical activity, self-esteem.

scholarly journals Influence of complex treatment on the functional state of the hepatobiliary system in patients with diabetes mellitus

2021 ◽  
pp. 4-9
Author(s):  
Gunay Adalat Valiyeva
Keyword(s):  
Diabetes Mellitus ◽  
Functional State ◽  
Control Group ◽  
Diabetic Patients ◽  
Complex Treatment ◽  
Group 13 ◽  
Hepatobiliary System ◽  
Number Of Patients ◽  
Patients With Diabetes ◽  
Group 10

Liver damage in diabetes mellitus is of particular interest, since this factor significantly affects the course of the disease, the level of compensation and prognosis of the underlying disease. The aim. To study the effect of complex treatment using ursosan on the functional state of the hepatobiliary system in patients with diabetes mellitus. Materials and methods. The study included 30 patients with type 1 diabetes mellitus and 48 patients with type 2 diabetes. According to the duration of diabetes, patients were divided into three subgroups: a) up to five years; b) 5–10 years; c) more than 10 years. The number of patients was: 1a group – 13, 1b group – 10, 1c group – 7 people; Group 2a – 23, 2b group – 13, 2c group – 10 people. The control group consisted of 23 apparently healthy people. Ursosan was prescribed at a dose of 10-12 mg per 1 kg of body per day for 6 months. Clinical laboratory and instrumental research methods were used to study the functional state of the liver and gallbladder. Research results. After the course of treatment with Ursosan, patients with diabetes mellitus showed normalization of protein, pigment, enzymatic metabolism and, to a lesser extent, lipid metabolism in the liver, which led to an improvement in cellular metabolism and redox processes, providing a stable course of diabetes. Conclusions. A 6-month course of treatment with Ursosan in diabetic patients promotes long-term diabetes compensation. Patients during treatment have a decrease in cytolysis syndrome indicators (alanine aminotransferase (AlAT), aspartate aminotransferase (AsAT), lactate dehydrogenesis (LDH)) by about 1.5 times in all 3 indicators compared to the indicators before treatment. The same trend was observed in terms of gamma-glutamine transferase (GGT) and alkaline phosphatase (ALP)

Clinical Implications of Anxiety in Diabetes: A Critical Review of the Evidence Base

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
C. Mitsonis ◽  
N. Dimopoulos ◽  
V. Psarra
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Anxiety Disorders ◽  
Evidence Base ◽  
Diabetic Patients ◽  
Strong Argument ◽  
General Anxiety Disorder ◽  
Significant Difference ◽  
Patients With Diabetes

Introduction:Substantial literature supports clinically important associations between anxiety and chronic medical conditions. Diabetes is among the most psychologically and behaviorally demanding chronic medical illnesses. Anxiety has been associated with poor glycemic control, regimen adherence, and with accelerated rates of coronary heart disease in diabetic patients.Aim:The aim of this study is to provide an overview of the role of clinically significant anxiety in patients with diabetes mellitus.Methods:MEDLINE, EMBASE and PSYCINFO databases were searched using the combined search terms diabetes, diabetes mellitus, anxiety symptoms and anxiety disorders. Published reference lists were also examined. In total 25 studies were identified that fulfilled the inclusion criteria.Results:Anxiety was present in 41.7% of diabetic patients. There was no significant difference between those with Types 1 and types 2 diabetes. The rate of elevated symptoms was significantly higher in diabetic women than in diabetic men. General anxiety disorder was the most prevalent of the clinical disorders and was found in 13.2% of the diabetic patients. The rates of the other anxiety disorders were within the range of those reported in community studies. Treatment of anxiety was associated with improved glycemic control, particularly in the subgroup of patients with severe anxiety.Conclusions:Emerging data offer a strong argument for the role of anxiety in diabetes. Psychological interventions and/ or pharmacological treatments in patients with diabetes are needed, in order to increase treatment adherence and control of the disease and improve patients’ functioning and quality of life.

scholarly journals Outcomes of Coronary Angioplasty in Diabetic Patients – A Retrospective Study

2016 ◽  
Vol 01 (02) ◽  
pp. 005-010
Author(s):  
Galla Kishore ◽  
Chandragiri Susmitha ◽  
P Rao
Keyword(s):  
Statistical Significance ◽  
Chronic Stable Angina ◽  
Coronary Intervention ◽  
Diabetic Patients ◽  
Coronary Syndrome ◽  
Major Cardiovascular Events ◽  
Number Of Patients ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
One Year

AbstractAims: We want to study the effect of diabetes Mellitus (DM) on the outcomes in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) comparing those with non diabetics, with reference to gender.Methods: We retrospectively evaluated the consecutive patients undergoing PCI either with acute coronary syndrome (ACS) or chronic stable angina (CSA) in our institute between March 2014 to March 2015. We followed them up to one year for the major cardiovascular events (MACES) and other complications. We compared the rate of events between diabetic and non diabetic patients along with gender subgroups and tested for the significance.Results: In 645 patients undergone PCI in our institute, 326(50.5%) were diabetics, of them 104(31.9%) were females. Patients with diabetes with CAD were older with more incidence of hypertension and kidney derangement than non diabetics. History of CAD and previous procedure are definitely more in diabetics as is multi vessel disease (p=0.02) and LV dysfunction (p=0.003). Total number of patients presenting with complications within one year of PCI is 18(0.02%). Of them 14 are males and 4 are females, 14 were diabetics and 4 were non diabetics. There was no statistical significance in the outcomes between female & males (p=0.7), diabetics females & diabetic males (p=0.48) and non diabetics females & nondiabetic males(p=0.7). Male patients with diabetes had significantly more complications than non diabetic males (p=0.05) but there is no significant difference between diabetic and non diabetic females (p=0.59).Conclusion: Patients with DM undergoing PCI had more complications than non diabetics with significant difference between male diabetics and non diabetic males. This difference is not significant between diabetic and non diabetic females.

scholarly journals Evaluation of proteinase and phospholipase activity of Candida albicans strains isolated from the mouth of patients with controlled and uncontrolled diabetes mellitus in Qazvin province: Short Communication

2021 ◽  
pp. 402-407
Keyword(s):  
Diabetes Mellitus ◽  
Candida Albicans ◽  
Hydrolytic Enzymes ◽  
Diabetic Patients ◽  
Target Tissue ◽  
Phospholipase Activity ◽  
Host Cell Membrane ◽  
Uncontrolled Diabetes ◽  
Significant Difference ◽  
Patients With Diabetes

Pathophysiological changes in the mouth of patients with diabetes mellitus (DM) predispose to overgrowth of Candida albicans. Various virulence factors such as proteinase and phospholipase production are involved in the process of degradation of the host cell membrane. These enzymes are involved in binding Candida species, especially in the hyphae stage, to the target tissue. In this study, the proteinase and phospholipase activity of 51 C. albicans strains was evaluated. Overall, the rates of proteolytic and phospholipase activities in controlled and uncontrolled diabetic patients were 90.2% and 72.5%, respectively. No significant difference was observed between proteinase and phospholipase activities in both groups of patients (P>0.05), while there was a significant difference between the activity of hydrolytic enzymes with HbA1C and dentures in the uncontrolled diabetic group (P<0.05). According to the importance of hydrolytic enzymes activity of C. albicans species in diabetic patients, oral health of diabetic patients to control and prevent disease progression in these patients is essential.

STUDY ON LEVEL OF ANTI GAD AND ICA AUTOANTIBODIES IN PATIENTSWITH DIABETES MELLITUS

2016 ◽  
pp. 78-85
Author(s):  
Thi Minh Phuong Phan ◽  
Dinh Thanh Truong
Keyword(s):  
Diabetes Mellitus ◽  
Statistical Significance ◽  
Enzyme Linked Immunosorbent Assay ◽  
Acid Decarboxylase ◽  
Diabetic Patients ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Positive Rate ◽  
The Difference ◽  
The One

Background: Autoantibodies anti GAD and ICA associated to the autoimmune process of patients with diabetes. Detection of these antibodies in progessive diabeticpatients is very necessary because the presence of anti GAD and ICA can predict the progression of the disease to insulin-dependent diabetes in the future. This study was carried out with aims: (1) to define the positive rate, anti GAD and ICA level in patients with diabetes. (2) to evaluate the correlation between anti GAD and ICA with several clinical and paraclinical features of diabetic patients. Materials and method: 88 patients diagnosed of diabetes by the criteria of ADA 2014, withfasting glucose ≥ 126 mg/dL or≥ 7,0 mmol/L) and HbA1C> 6.5%. Indirect enzyme linked immunosorbent assay (ELISA) was used to measure those autoantibodies of anti GAD and ICA, kits were supplied by DRG company, Germany. Results: the anti GAD positive rate was 10.2%; mean of level of anti GAD was 1.44±0.25 U/mL. ICA positive ratewas 9.1%; mean of level of ICA was 1.44±0.12 U/mL. Positive rate with anti GAD and/or ICA was 19.3%. About the correlation between level of anti GAD, ICA with some of clinical features, we found only the statistically significant difference with p<0.05 between blur vision in the group of ICA level > 1.25U/mL with group of ICA level< 1.25U/mL. About the paraclinical features, the difference with statistical significance (p<0.05) of HbA1C>6.5% was found between the group with anti GAD> 1.05U/mLand the one with anti GAD< 1.00U/mLand also betweenthe group of ICA > 1.25 U/mL and ICA < 1.25 U/mL. Key words: autoantibody anti glutamic acid decarboxylase, islet cell autoantibodies, diabetes mellitus.

Abstract 135: Low Income Patients With Diabetes: High Risk For Uncontrolled Hypertension?

2013 ◽  
Vol 6 (suppl_1) ◽  
Author(s):  
Adesuwa Olomu ◽  
Venu Gourineni ◽  
Bethany Buda ◽  
David Todem ◽  
Wei-Wen Hsu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Low Income ◽  
Underserved Populations ◽  
Total Sample ◽  
Uncontrolled Hypertension ◽  
Diabetic Patients ◽  
Immigration Status ◽  
Number Of Patients ◽  
Patients With Diabetes

Introduction: Cardiovascular disease and not hyperglycemia is the major cause of mortality in patients with diabetes mellitus (DM). Hypertension is particularly burdensome in low income groups, where the prevalence of uncontrolled hypertension is higher than the general population. Federally Qualified Health Centers (FQHCs) provide care for low income and medically underserved populations (both immigrant and non-immigrant population). Objectives: 1) to determine the rate and predictors of Blood Pressure (BP) control in patients with diabetes and hypertension. 2) to identify differences by immigration status in BP control among patients attending FQHCs. Methods: The Office Guidelines Applied to Practice (Office-GAP) study is a cluster randomized trial designed to improve cardiovascular care for minority and low income populations in outpatient clinical settings. Office-GAP intervention included: provider training, patient education in a group visit, and use of Office-GAP checklist and patient decision aids during office visits. We describe baseline patient characteristics (prior to any intervention) in the FQHC sites. Retrospective review was performed of charts of all patients with hypertension, coronary artery disease and or, diabetes mellitus (DM) from September 2010 to December 2012. Hypertension was defined as Systolic BP>140 mmHg (>130 mm Hg in DM patients) and diastolic BP > 90 mmHg (>80 mm Hg in DM patients). A multivariable logistic regression was used to assess the effects of potential predicators on BP control. Results: Of 242 patients identified, 169 had DM, and 166 had hypertension. The mean age was 54.47 ± 11.91 years and 44.39 % were men (99 of 223). Of the total sample, 178 (73.55%, 178 of 242) were non-immigrants, 23.87 % (53 of 222) were covered by Medicaid, 40.99% (91 of 222) by Medicare, 39.19 % (87 of 222) by county outpatient insurance; 33.06% (70 of 242) were Black, 34.71 % (84 of 242) White and 32.23% (78 of 242) formed other races (Hispanics, Somalis, Nepalese). BP control was 36.73% (83 of 226) 95% CI = [30.44, 43.02] and 27.22% (46 of 169) 95% CI = [20.51, 33.93] in total sample and DM patients respectively. BP control among immigrants was 32.2% (19 of 59) 95% CI = [20.28, 44.12] vs. 38.32% (64 of 167) 95% CI = [30.95, 45.69] in non-immigrants. A logistic regression model identify the DM status as the sole significant predictor associated with BP control, with patients without DM having the best BP control (p-value<0.0001). This effect of DM on BP control remained significant even after adjusted for other predictors. Conclusions: We found that significant number of patients attending FQHCs do not have their BP controlled. Immigration status did not play any role in BP control; however BP control among patients with DM was substantially lower than the whole sample. This underscores the urgent need for strategies to improve BP control in FQHCs, particularly among diabetic patients.

scholarly journals Study of TSH level at the time of diagnosis of Hypothyroidism in patients with Diabetes Mellitus- A Retrospective Study

2020 ◽  
Vol 4 (2) ◽  
pp. 24-28
Author(s):  
Indu K.C. ◽  
S Ghimire ◽  
R Deo
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Kidney Disease ◽  
P Value ◽  
Diabetic Patients ◽  
Significant Difference ◽  
Other Information ◽  
Patients With Diabetes ◽  
History Of ◽  
The Mean ◽  
The Difference

Background: To evaluate the difference in the level of TSH in diabetic and non diabetic patients at the time of the diagnosis of hypothyroidism. Methods: 100 diagnosed cases of hypothyroidism, 50 with diabetes and 50 without diabetes were studied. The level of TSH at the time of diagnosis and other information were obtained from the medical records. Results: The mean TSH in patients with the history of diabetes at the diagnosis of hypothyroidism was 19.9616±26.990 and in those without the history of the diabetes was 10.4797±6.503 (p value 0.018). The females with diabetes had higher level of TSH level at the time of diagnosis of hypothyroidism than females without diabetes (p value 0.045). There was no statistically significant difference in the level of TSH in males with and without diabetes at the time of diagnosis of hypothyroidism. Conclusion: Patients with diabetes mellitus had higher level of TSH at the time of diagnosis of hypothyroidism in comparison to those without diabetes. Early identification of the raised TSH levels in diabetic patients and timely intervention will help to reduce the chances of adverse cardiovascular outcomes and diabetic kidney disease in this group of patients.

scholarly journals Estimation of Vascular Cell Adhesion Molecule 1 (VCAM-1) Levels In Type 1 Diabetic Mellitus Patients

Bionatura ◽  
2021 ◽  
Vol 6 (4) ◽  
pp. 2292-2294
Author(s):  
Ousamha Akram Saterr ◽  
Abeer J. Hassan ◽  
Qahtan Adnan Rasheed
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Microvascular Complications ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Diabetic Patients ◽  
Insulin Levels ◽  
Significant Difference ◽  
Patients With Diabetes

High glucose levels in patients with diabetes are associated with increased plasma levels of soluble adhesion molecules. They could explain that the patients with diabetes mellitus will require the development of premature atherosclerosis related to hyperglycemia or hyperinsulinemia and that it not only affects vascular endothelium but also contributes to the development of microvascular complications. This study aimed to evaluate the serum concentration of VCAM-1 in type 1 diabetes mellitus patients with and without cardiovascular disease. Also, investigation the association of insulin levels, duration of diabetes, and HbA1C with VCAM-1. Include in this study a total of 60 types 1 diabetic patient. According to characteristic laboratory investigations and electrocardiogram (ECG), they were subdivided into two groups (G1) 30 T1DM patients without cardiovascular disease and (G2) 30 T1DM patients with cardiovascular disease in addition to 30 healthy subjects as a control group (G3). All subjects measured the levels of fasting blood glucose FBG, glycated hemoglobin HbA1c, and insulin levels, and VCAM-1 were also determined by ELISA technique. This study shows a highly significant difference in the average diabetic profile between G1 and G2 compared to the control group and found that VCAM-1 level was significantly higher among diabetic patients than the control group. Also, there was a significant negative correlation of VCAM-1 with the levels of FBG, HbA1c in diabetic patients G1 and G2. While insulin had a positive correlation in G1 but correlated negatively in G2

scholarly journals Metformin Intake Suppresses The Degree of Liver Metastasis From Colorectal Cancer In Diabetic Patients But Does Not Improve Their Prognosis

2021 ◽  
Author(s):  
Akira Saito ◽  
Joji Kitayama ◽  
Hisanaga Horie ◽  
Koji Koinuma ◽  
Hideyuki Ohzawa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Hepatic Metastases ◽  
Stage Iv ◽  
University Hospital ◽  
Diabetic Patients ◽  
Significant Difference ◽  
Patients With Diabetes

Abstract Background: Metformin reduces the risk of, and mortality from, colorectal cancer in patients with diabetes mellitus. However, the effect of metformin on patients with stage IV disease is unknown. In the present study we reviewed the clinical features and outcomes of patients with diabetes mellitus and stage IV colorectal cancer (M1, liver metastases) treated with or without metformin.Methods: The 202 patients with colorectal cancer and macroscopic liver metastasis who were treated in the Department of Surgery or Department of Clinical Oncology at Jichi Medical University Hospital from January 2006 through June 2019 were surveyed treatment of diabetes, clinical and pathological factor and prognosis of these patients. Results: We retrospectively examined the effect of metformin use on outcomes in 32 patients with liver metastases from colorectal cancer. Hepatic metastases were stage H1 in 8/8 patients taking metformin and stage H2-3 in 17/24 non-users. Of 22 patients who underwent colectomy, colorectal tumors were pT4 in 5 metformin users, and pT2-3 in 10/17 non-users. The mean survival of metformin users and non-users was equal (28.0 mo vs 29.3 mo, p>.05). No significant difference was detected when survival was compared between 6 metformin users and 19 non-users who received systemic chemotherapy. Conclusion: These results suggest that metformin has less potent anti-tumor effects in patients with advanced stage disease. Metformin for the treatment of patients with metastatic colorectal cancer requires further study.

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