scholarly journals Herpes Encephalitis Masquerading as Tumor

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Tasneem Peeraully ◽  
Joseph C. Landolfi

A 54 year old lady presented with lethargy and 15 kg weight loss over the past year. CT scan of the head revealed left temporal lobe hypodensity with a discrete area of hemorrhage within the left mesial temporal lobe. Due to concerns about impending central herniation, lumbar puncture was not performed. MRI of the brain showed a large lesion of the left temporal lobe, extending to the left frontal lobe, and very patchy meningeal enhancement. There was a noncontiguous lesion of the right insula. A differential diagnosis of herpes simplex encephalitis (HSE) and multifocal infiltrative glioma was entertained. MR spectroscopy demonstrated an increased choline peak at the level of the medial left temporal lobe and MR perfusion demonstrated patchy areas of hyperperfusion within the left anterior temporal lobe, both suggestive of neoplastic disease. Following open brain biopsy, pathology revealed herpes simplex virus (HSV) positive nuclei in the cortex and subcortical white matter. As both herpes simplex encephalitis and low-grade glioma demontrate MRI findings of hypointensity on T1 images and hyperintensity on T2 images, the diagnosis of herpes encephalitis can be clouded by confounding factors, especially when cerebrospinal fluid (CSF) cannot be obtained.

1994 ◽  
Vol 75 (9) ◽  
pp. 1053-1054
Author(s):  
Aubrey Ku ◽  
Elisabeth A. Lachmann ◽  
Hilary B. Kern ◽  
Willibald Nagler

2015 ◽  
Vol 05 (02) ◽  
pp. 133-135
Author(s):  
Özkan ünal ◽  
Cahide Yılmaz ◽  
Ahmet Güven ◽  
Özlem Özen ◽  
Hüseyin Çaksen

2011 ◽  
Vol 8 (4) ◽  
pp. 402-406 ◽  
Author(s):  
Matthew A. Adamo ◽  
Lisa Abraham ◽  
Ian F. Pollack

Herpesviruses can cause an acute, subacute, or chronic disease state in both immunocompetent and immunocompromised individuals. Herpes simplex virus (HSV) encephalitis is most often an acute monophasic disease process. Rarely, however, it may progress to a chronic state, and more rarely still to a granulomatous encephalitis. Prior studies have suggested that antiviral immunity with Toll-like receptors determines susceptibility to herpesviruses. The authors report the case of a 14-year-old girl with a remote history of treated HSV encephalitis, who had intractable seizures and worsening MR imaging changes that were concerning for either a neoplastic or an inflammatory process. She was found to have granulomatous herpes simplex encephalitis and had a low cytokine response to Toll-like receptor 3 stimulation.


2013 ◽  
Vol 4 (1) ◽  
pp. 42-43
Author(s):  
Eli L. Diamond ◽  
Vaios Hatzoglou ◽  
Bianca Santomasso ◽  
Marc Rosenblum ◽  
Elena Pentsova

2003 ◽  
Vol 33 (10) ◽  
pp. 725-728 ◽  
Author(s):  
Aya M. Tokumaru ◽  
Katsuyuki Horiuchi ◽  
Tatsumi Kaji ◽  
Shinya Kohyama ◽  
Ikuko Sakata ◽  
...  

2020 ◽  
Vol 10 (9) ◽  
pp. 2223-2227
Author(s):  
Rui Mei ◽  
Fang Fan ◽  
Lu Lv ◽  
Fang Wang ◽  
Xiaobo Liu ◽  
...  

The purpose of this study is to investigate the effects of family therapy on brain computed tomography (CT) information in unipolar depression patients. In this study, 35 cases of unipolar depression patients who visited xxx hospital from March 2017 to August 2019 but received no systematic treatment were taken as the study subjects. CT scan was used to detect and compare the CT values of left frontal lobe, right frontal lobe, left temporal lobe and right temporal lobe of patients with depression before and three months after family treatment. Patients’ levels of depression and anxiety before and after treatment were determined by Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA). The cognitive function of patients before and after treatment was evaluated by Mini Mental State Examination (MMSE). The physical and social function, and mental health of them were assessed by health status questionnaire (SF-36). The correlation between CT values of each lobe and clinical characteristics of patients was analyzed by multivariate linear regression model. The results showed that the CT values and SF-36 scores of the left and right frontal lobe after treatment were significantly higher than that before treatment (P < 0.05), while the HAMD MMSE scores were significantly lower than those before treatment (P < 0.05). The linear-regression analysis results showed that CT values of the left frontal lobe were negatively correlated with the patient’s age and disease course (P < 0.05), and CT values of the right frontal lobe were negatively correlated with the patient’s age (P < 0.05), and CT values of the left temporal lobe were negatively correlated with the patient’s disease course (P < 0.05). It indicates that the pathogenesis of depression is related to the function of brain structure. However, the social ability of unipolar depression patients and their emotional depression and psychological state can be effectively improved by family therapy, which also has a significant effect on the recovery of the disease.


Author(s):  
Yun Jiang ◽  
Liya Tang ◽  
Ping Gao ◽  
Shaosen Qin ◽  
Jingwen Jiang

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