scholarly journals New Way to Substitute Tetracyanocyclopropanes: One-Pot Cascade Assembling of Carbonyls and Malononitrile by the Only Bromine Direct Action

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Anatolii N. Vereshchagin ◽  
Michail N. Elinson ◽  
Nikita O. Stepanov ◽  
Gennady I. Nikishin
Keyword(s):  
Pharmacological Activity ◽  
Carbonyl Compounds ◽  
Cyclopropane Ring ◽  
Direct Action ◽  
Cascade Reaction ◽  
One Pot ◽  
Different Types ◽  
New Type

The new type of the chemical cascade reaction was found: formation of cyclopropanes from carbonyl compounds and CH acid by the only bromine direct action. The action of aqueous bromine on the carbonyl compounds and malononitrile in EtOH-H2O solutions in the presence of NaOAc results in the formation of 3-substituted 1,1,2,2-tetracyanocyclopropanes in 48–93% yields. The latter are well-known precursors for the different bicyclic heterosystems, among them those containing cyclopropane ring and those possessing different types of pharmacological activity.

A new type of cascade reaction: direct conversion of carbonyl compounds and malononitrile into substituted tetracyanocyclopropanes

Tetrahedron ◽  
2009 ◽  
Vol 65 (31) ◽  
pp. 6057-6062 ◽  
Author(s):  
Michail N. Elinson ◽  
Anatolii N. Vereshchagin ◽  
Nikita O. Stepanov ◽  
Alexey I. Ilovaisky ◽  
Alexander Ya. Vorontsov ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Direct Conversion ◽  
Cascade Reaction ◽  
New Type

ChemInform Abstract: A New Type of Cascade Reaction: Direct Conversion of Carbonyl Compounds and Malononitrile into Substituted Tetracyanocyclopropanes.

ChemInform ◽  
2009 ◽  
Vol 40 (47) ◽  
Author(s):  
Michail N. Elinson ◽  
Anatolii N. Vereshchagin ◽  
Nikita O. Stepanov ◽  
Alexey I. Ilovaisky ◽  
Alexander Ya. Vorontsov ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Direct Conversion ◽  
Cascade Reaction ◽  
New Type

One-Pot, Regioselective Synthesis of Homopropargyl Alcohols using Propargyl Bromide and Carbonyl Compound by the Mg-mediated Reaction under Solvent-free Conditions

2020 ◽  
Vol 17 (6) ◽  
pp. 438-442
Author(s):  
Xiaofang Ma ◽  
Shunxi Li ◽  
Samrat Devaramani ◽  
Guohu Zhao ◽  
Daqian Xu
Keyword(s):  
Reaction Time ◽  
Organic Synthesis ◽  
Carbonyl Compounds ◽  
Solvent Free ◽  
Propargyl Bromide ◽  
Important Goal ◽  
One Pot ◽  
Short Reaction Time ◽  
Solvent Free Conditions ◽  
Volatile Organic

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.

Aza-Diels-Alder Reaction Between 1,2-Diaza-1,3-dienes and β-Aryl-α,β-unsaturated Carbonyl Compounds. Easy One-pot Entry to 2’-Oxo-imidazo[1’,5’- f]tetrahydropyridazine

2014 ◽  
Vol 10 (6) ◽  
pp. 951-960
Author(s):  
Orazio Attanasi ◽  
Luca Bianchi ◽  
Maurizio D’Auria ◽  
Gianfranco Favi ◽  
Fabio Mantellini ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Alder Reaction ◽  
Diels Alder ◽  
One Pot ◽  
Diels Alder Reaction

A metal-free yne-addition/1,4-aryl migration/decarboxylation cascade reaction of alkynoates with Csp3–H centers

2016 ◽  
Vol 14 (7) ◽  
pp. 2210-2217 ◽  
Author(s):  
De-Long Kong ◽  
Liang Cheng ◽  
Hong-Ru Wu ◽  
Yang-Xiong Li ◽  
Dong Wang ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Single Site ◽  
Metal Free ◽  
Different Types

Reactions of alkynoates with different types of radical precursors under metal-free conditions affording single-site-addition poly-substituted alkenes were reported.

ChemInform Abstract: Synthesis of Benzo[c]fluorenone Through a One-Pot Cascade Reaction Using Inden-1-one Derivatives.

ChemInform ◽  
2014 ◽  
Vol 45 (24) ◽  
pp. no-no
Author(s):  
Shuyan Zheng ◽  
Hongsheng Tan ◽  
Xiaoguang Zhang ◽  
Chunhui Yu ◽  
Zhengwu Shen
Keyword(s):  
Cascade Reaction ◽  
One Pot

scholarly journals 1,3-Diketone Calix[4]arene Derivatives—A New Type of Versatile Ligands for Metal Complexes and Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1214
Author(s):  
Sergey N. Podyachev ◽  
Rustem R. Zairov ◽  
Asiya R. Mustafina
Keyword(s):  
Structural Diversity ◽  
Building Blocks ◽  
Structural Features ◽  
Structure Property ◽  
One Pot ◽  
Arene Ligands ◽  
Structure Property Relationships ◽  
New Type ◽  
Synthetic Routes ◽  
Magnetic Resonance Imaging Mri

The present review is aimed at highlighting outlooks for cyclophanic 1,3-diketones as a new type of versatile ligands and building blocks of the nanomaterial for sensing and bioimaging. Thus, the main synthetic routes for achieving the structural diversity of cyclophanic 1,3-diketones are discussed. The structural diversity is demonstrated by variation of both cyclophanic backbones (calix[4]arene, calix[4]resorcinarene and thiacalix[4]arene) and embedding of different substituents onto lower or upper macrocyclic rims. The structural features of the cyclophanic 1,3-diketones are correlated with their ability to form lanthanide complexes exhibiting both lanthanide-centered luminescence and magnetic relaxivity parameters convenient for contrast effect in magnetic resonance imaging (MRI). The revealed structure–property relationships and the applicability of facile one-pot transformation of the complexes to hydrophilic nanoparticles demonstrates the advantages of 1,3-diketone calix[4]arene ligands and their complexes in developing of nanomaterials for sensing and bioimaging.

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