scholarly journals Living Donor Liver Transplantation for Caroli's Disease: A Report of Two Cases

ISRN Surgery ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Klaus Steinbrück ◽  
Marcelo Enne ◽  
Reinaldo Fernandes ◽  
Jose M. Martinho ◽  
Lúcio F. Pacheco-Moreira
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Autosomal Recessive Disorder ◽  
Meld Score ◽  
Donor Liver ◽  
Caroli's Disease ◽  
Caroli’S Disease ◽  
Donor Liver Transplantation ◽  
Feasible Option

Caroli's disease (CD) is a rare autosomal recessive disorder characterized by intrahepatic cystic dilatation of the bile ducts. Patients with bilobar or progressive disease may require orthotopic liver transplantation (OLT). In the MELD era, living donor liver transplantation (LDLT) raised as the ultimate treatment option for these patients, once their MELD score is usually low. Herein, we describe 2 cases of patients (a 2-year-old girl and a 19-year-old teenager) that successfully underwent LDLT as a treatment for diffuse CD. The good postoperative courses of the two cases indicate that LDLT is a feasible option in the treatment of this disorder, even in complicated or early age patients.

Living-donor liver transplantation for Caroli's disease with intrahepatic adenocarcinoma

2001 ◽  
Vol 8 (3) ◽  
pp. 284-286 ◽  
Author(s):  
Mitsuhisa Takatsuki ◽  
Shinji Uemoto ◽  
Yukihiro Inomata ◽  
Hiroto Egawa ◽  
Tetsuya Kiuchi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Donor Liver ◽  
Caroli's Disease ◽  
Caroli’S Disease ◽  
Donor Liver Transplantation

Is Muscle MELD a More Promising Predictor for Mortality After Living Donor Liver Transplantation?

2018 ◽  
Vol 28 (3) ◽  
pp. 213-219
Author(s):  
Amr Badawy ◽  
Toshimi Kaido ◽  
Yuhei Hamaguchi ◽  
Takayuki Anazawa ◽  
Shintaro Yagi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Postoperative Outcome ◽  
Predictive Performance ◽  
Meld Score ◽  
Operating Characteristics ◽  
Donor Liver ◽  
Discriminative Performance ◽  
Donor Liver Transplantation

Background: To improve the outcome of living donor liver transplantation (LDLT), a scoring system that could predict accurately the patient and graft survival posttransplant is necessary. The aim of this study is to evaluate our previously proposed Muscle-model for end-stage liver disease (M-MELD) score and to compare it with the other available scores to find the best system that correlates with postoperative outcome after liver transplant. Methods: We retrospectively reviewed the data of 199 patients who underwent LDLT from January 2010 to July 2016 and calculated the preoperative MELD, MELD Na, the product of donor age and MELD (D-MELD), M-MELD, integrated MELD, and the balance of risk (BAR) score in all patients. The area under the receiver operating characteristics curves (AUCs) of each score was computed and compared at 3-, 6-months, and 1-year after LDLT. Results: The M-MELD, D-MELD, and integrated MELD had a good discriminative performance in predicting 3-month mortality after LDLT with AUCs > 0.7, while the M-MELD was the only score that showed a good discriminative performance in predicting 6-month and 1-year mortality after LDLT with AUCs > 0.7. Conclusion: Muscle-MELD score is a simple and useful predictor of patient survival after LDLT which showed a better predictive performance than other available scores.

scholarly journals Predictive factors of early graft loss in living donor liver transplantation

2012 ◽  
Vol 49 (2) ◽  
pp. 157-161 ◽  
Author(s):  
Rogério Camargo Pinheiro Alves ◽  
Eduardo Antunes da Fonseca ◽  
Carla Adriana Loureiro de Mattos ◽  
Sofia Abdalla ◽  
José Eduardo Gonçalves ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Serum Sodium Level ◽  
Graft Loss ◽  
Meld Score ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Group I ◽  
Early Graft

CONTEXT: Living donor liver transplantation has become an alternative to reduce the lack of organ donation. OBJECTIVE: To identify factors predictive of early graft loss in the first 3 months after living donor liver transplantation. METHODS: Seventy-eight adults submitted to living donor liver transplantation were divided into group I with 62 (79.5%) patients with graft survival longer than 3 months, and group II with 16 (20.5%) patients who died and/or showed graft failure within 3 months after liver transplantation. The variables analyzed were gender, age, etiology of liver disease, Child-Pugh classification, model of end-stage liver disease (MELD score), pretransplantation serum sodium level, and graft weight-to-recipient body weight (GRBW) ratio. The GRBW ratio was categorized into < 0.8 and MELD score into >18. The chi-square test, Student t-test and uni- and multivariate analysis were used for the evaluation of risk factors for early graft loss. RESULTS: MELD score <18 (P<0.001) and serum sodium level > 135 mEq/L (P = 0.03) were higher in group II than in group I. In the multivariate analysis MELD scores > 18 (P<0.001) and GRBW ratios < 0.8 (P<0.04) were significant. CONCLUSIONS: MELD scores >18 and GRBW < 0.8 ratios are associated with higher probability of graft failure after living donor liver transplantation.

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