scholarly journals The Influence of Health Perception on Shoulder Outcome Measure Scores

2019 ◽  
Vol 22 (4) ◽  
pp. 173-182
Author(s):  
Richard E. Hardy ◽  
Engin Sungur ◽  
Christopher Butler ◽  
Jefferson C. Brand
Keyword(s):  
Outcome Measures ◽  
Prediction Models ◽  
Constant Score ◽  
Case Series ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Level Of Evidence ◽  
Individualized Care ◽  
Sf 36 ◽  
Patient Reported

Background: Patient reported outcome measures assess clinical progress from the patient’s perspective. This study explored the relationship between shoulder outcome measures (The Disability of the Arm, Shoulder and Hand [DASH], American Shoulder and Elbow Surgeons Standard Shoulder Assessment score [ASES], and Constant score) by comparing the best possible scores obtained in an asymptomatic population compared to overall perception of health, as measured by the SF-36 outcome measure.Methods: Volunteers (age range, 20?69 years) with asymptomatic shoulders and no history of shoulder pain, injury, surgery, imaging, or pathology (bilaterally) were included. The DASH and ASES measures were completed by 111 volunteers (72 female, 39 male), of which 92 completed the Constant score (56 female, 36 male). The SF-36 was completed by all volunteers (level of evidence: IV case series).Results: The mean (x) score for ASES measure on the right shoulder was higher for the left-hand dominant side (x=100.00 vs. 95.02, <i>p</i>-value<0.001); no other significant differences. Better SF-36 scores were associated with better DASH scores. Our prediction models suggest that perception of overall health affects the DASH scores. Sex affected all three shoulder measures scores.Conclusions: Comparing scores of shoulder outcome measures to the highest possible score is not the most informative way to interpret patient progress. Variables such as health status, sex, and hand dominance need to be considered. Furthermore, it is possible to use these variables to predict scores of outcome measures, which facilitates the healthcare provider to deliver individualized care to their patients.

scholarly journals Enabling patient-reported outcome measures in clinical trials, exemplified by cardiovascular trials

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Theresa M. Coles ◽  
Adrian F. Hernandez ◽  
Bryce B. Reeve ◽  
Karon Cook ◽  
Michael C. Edwards ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Outcome Measures ◽  
Contextual Factors ◽  
The United States ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Think Tank ◽  
Level Of Evidence ◽  
Patient Reported ◽  
Evidentiary Standards

Abstract Objectives There has been limited success in achieving integration of patient-reported outcomes (PROs) in clinical trials. We describe how stakeholders envision a solution to this challenge. Methods Stakeholders from academia, industry, non-profits, insurers, clinicians, and the Food and Drug Administration convened at a Think Tank meeting funded by the Duke Clinical Research Institute to discuss the challenges of incorporating PROs into clinical trials and how to address those challenges. Using examples from cardiovascular trials, this article describes a potential path forward with a focus on applications in the United States. Results Think Tank members identified one key challenge: a common understanding of the level of evidence that is necessary to support patient-reported outcome measures (PROMs) in trials. Think Tank participants discussed the possibility of creating general evidentiary standards depending upon contextual factors, but such guidelines could not be feasibly developed because many contextual factors are at play. The attendees posited that a more informative approach to PROM evidentiary standards would be to develop validity arguments akin to courtroom briefs, which would emphasize a compelling rationale (interpretation/use argument) to support a PROM within a specific context. Participants envisioned a future in which validity arguments would be publicly available via a repository, which would be indexed by contextual factors, clinical populations, and types of claims. Conclusions A publicly available repository would help stakeholders better understand what a community believes constitutes compelling support for a specific PROM in a trial. Our proposed strategy is expected to facilitate the incorporation of PROMs into cardiovascular clinical trials and trials in general.

scholarly journals Return to Sport After Large Single-Surface, Multisurface, or Bipolar Osteochondral Allograft Transplantation in the Knee Using Shell Grafts

2021 ◽  
Vol 9 (1) ◽  
pp. 232596712096792
Author(s):  
James L. Cook ◽  
Kylee Rucinski ◽  
Cory R. Crecelius ◽  
Richard Ma ◽  
James P. Stannard
Keyword(s):  
Femoral Condyle ◽  
Case Series ◽  
Return To Sport ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Osteochondral Allograft ◽  
Level Of Evidence ◽  
Recreational Athletes ◽  
Patient Reported

Background: Return to sport (RTS) after osteochondral allograft (OCA) transplantation for large unipolar femoral condyle defects has been consistent, but many athletes are affected by more severe lesions. Purpose: To examine outcomes for athletes who have undergone large single-surface, multisurface, or bipolar shell OCA transplantation in the knee. Study Design: Case series; Level of evidence, 4. Methods: Data from a prospective OCA transplantation registry were assessed for athletes who underwent knee transplantation for the first time (primary transplant) between June 2015 and March 2018 for injury or overuse-related articular defects. Inclusion criteria were preinjury Tegner level ≥5 and documented type and level of sport (or elite unit active military duty); in addition, patients were required to have a minimum of 1-year follow-up outcomes, including RTS data. Patient characteristics, surgery type, Tegner level, RTS, patient-reported outcome measures (PROMs), compliance with rehabilitation, revisions, and failures were assessed and compared for statistically significant differences. Results: There were 37 included athletes (mean age, 34 years; range, 15-69 years; mean body mass index, 26.2 kg/m2; range, 18-35 kg/m2) who underwent large single-surface (n = 17), multisurface (n = 4), or bipolar (n = 16) OCA transplantation. The highest preinjury median Tegner level was 9 (mean, 7.9 ± 1.7; range, 5-10). At the final follow-up, 25 patients (68%) had returned to sport; 17 (68%) returned to the same or higher level of sport compared with the highest preinjury level. The median time to RTS was 16 months (range, 7-26 months). Elite unit military, competitive collegiate, and competitive high school athletes returned at a significantly higher proportion ( P < .046) than did recreational athletes. For all patients, the Tegner level at the final follow-up (median, 6; mean, 6.1 ± 2.7; range, 1-10) was significantly lower than that at the highest preinjury level ( P = .007). PROMs were significantly improved at the final follow-up compared with preoperative levels and reached or exceeded clinically meaningful differences. OCA revisions were performed in 2 patients (5%), and failures requiring total knee arthroplasty occurred in 2 patients (5%), all of whom were recreational athletes. Noncompliance was documented in 4 athletes (11%) and was 15.5 times more likely ( P = .049) to be associated with failure or a need for revision than for compliant patients. Conclusion: Large single-surface, multisurface, or bipolar shell OCA knee transplantations in athletes resulted in two-thirds of these patients returning to sport at 16 to 24 months after transplantation. Combined, the revision and failure rates were 10%; thus, 90% of patients were considered to have successful 2- to 4-year outcomes with significant improvements in pain and function, even when patients did not RTS.

Assessment of computer adaptive testing version of the Neuro-QOL for people with multiple sclerosis

2018 ◽  
Vol 25 (13) ◽  
pp. 1791-1799 ◽  
Author(s):  
Brian C Healy ◽  
Jonathan Zurawski ◽  
Cindy T Gonzalez ◽  
Tanuja Chitnis ◽  
Howard L Weiner ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Outcome Measures ◽  
Computerized Adaptive Testing ◽  
Short Form ◽  
Patient Reported Outcome Measures ◽  
Adaptive Testing ◽  
Patient Reported Outcome ◽  
Longitudinal Change ◽  
Sf 36 ◽  
Patient Reported

Background: To date, the computerized adaptive testing (CAT) version of the Neuro-quality of life (QOL) has not been assessed in a large sample of people with multiple sclerosis (MS). Objective: The aim of this study was to assess the associations between the CAT version of Neuro-QOL and other clinical and patient-reported outcome measures. Methods: Subjects ( n = 364) enrolled in SysteMS completed the CAT version of the Neuro-QOL and the 36-Item Short Form Survey (SF-36) within 4 weeks of a clinical exam that included the Multiple Sclerosis Functional Composite-4 (MSFC-4). The correlations between the Neuro-QOL domains and the MSFC-4 subscores and the SF-36 scores were calculated. The changes over time in the Neuro-QOL and other measures were also examined. Results: The lower extremity functioning score of the Neuro-QOL showed the highest correlations with MSFC-4 components including Timed 25-Foot Walk, 9-Hole Peg Test, and cognitive score. The expected domains of the Neuro-QOL showed high correlations with the SF-36 subscores, and some Neuro-QOL domains were associated with many SF-36 subscores. There was limited longitudinal change on the Neuro-QOL domains over 12 months, and the change was not associated with change on other measures. Conclusion: The CAT version of the Neuro-QOL shows many of the expected associations with clinical and patient-reported outcome measures.

Patient-reported outcome measures after surgery for an acetabular fracture

2018 ◽  
Vol 100-B (5) ◽  
pp. 640-645 ◽  
Author(s):  
B. Frietman ◽  
J. Biert ◽  
M. J. R. Edwards
Keyword(s):  
Outcome Measures ◽  
Hip Joint ◽  
Acetabular Fracture ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Ct Scans ◽  
Sf 36 ◽  
Patient Reported ◽  
Post Traumatic

Aims The aim of this study was to record the incidence of post-traumatic osteoarthritis (OA), the need for total hip arthroplasty (THA), and patient-reported outcome measures (PROMS) after surgery for a fracture of the acetabulum, in our centre. Patients and Methods All patients who underwent surgery for an acetabular fracture between 2004 and 2014 were included. Patients completed the 36-Item Short Form Health Survey (SF-36) and the modified Harris Hip Score (mHHS) questionnaires. A retrospective chart and radiographic review was performed on all patients. CT scans were used to assess the classification of the fracture and the quality of reduction. Results A total of 220 patients were included, of which 55 (25%) developed post-traumatic OA and 33 (15%) underwent THA. A total of 164 patients completed both questionnaires. At a mean follow-up of six years (2 to 10), the mean SF-36 score for patients with a preserved hip joint was higher on role limitations due to physical health problems than for those with OA or those who underwent THA. In the dimension of bodily pain, patients with OA had a significantly better score than those who underwent THA. Patients with a preserved hip joint had a significantly better score on the function scale of the mHHS and a better total score than those with OA or who underwent THA. Conclusion Of the patients who were treated surgically for an acetabular fracture (with a mean follow-up of six years), 15% underwent THA at a mean of 2.75 years postoperatively. Patients with a THA had a worse functional outcome than those who retain their native hip joint. We recommend using PROMS and CT scans when reviewing these patients. Cite this article: Bone Joint J 2018;100-B:640–5.

scholarly journals Measurement Properties of Patient-Reported Outcome Measures for Diabetes: Systematic Review

10.2196/25002 ◽  
2021 ◽  
Vol 23 (8) ◽  
pp. e25002
Author(s):  
Priscilla Jia Ling Wee ◽  
Yu Heng Kwan ◽  
Dionne Hui Fang Loh ◽  
Jie Kie Phang ◽  
Troy H Puar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Outcome Measures ◽  
Systematic Reviews ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Measurement Properties ◽  
Level Of Evidence ◽  
Patient Reported

Background The management of diabetes is complex. There is growing recognition of the use of patient-reported outcome measures (PROMs) as a standardized method of obtaining an outlook on patients’ functional status and well-being. However, no systematic reviews have summarized the studies that investigate the measurement properties of diabetes PROMs. Objective Our aims were to conduct a systematic review of studies investigating the measurement properties of diabetes PROMs by evaluating the methodological quality and overall level of evidence of these PROMs and to categorize them based on the outcome measures assessed. Methods This study was guided by the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. Relevant articles were retrieved from the Embase, PubMed, and PsychINFO databases. The PROMs were evaluated with the COSMIN (COnsensus-based Standards for the selection of health Measurement Instruments) guidelines. Results A total of 363 articles evaluating the measurement properties of PROMs for diabetes in the adult population were identified, of which 238 unique PROMs from 248 studies reported in 209 articles were validated in the type 2 diabetes population. PROMs with at least a moderate level of evidence for ≥5 of 9 measurement properties include the Chinese version of the Personal Diabetes Questionnaire (C-PDQ), Diabetes Self-Management Instrument Short Form (DSMI-20), and Insulin Treatment Appraisal Scale in Hong Kong primary care patients (C-ITAS-HK), of which the C-PDQ has a “sufficient (+)” rating for >4 measurement properties. A total of 43 PROMs meet the COSMIN guidelines for recommendation for use. Conclusions This study identified and synthesized evidence for the measurement properties of 238 unique PROMs for patients with type 2 diabetes and categorized the PROMs according to their outcome measures. These findings may assist clinicians and researchers in selecting appropriate high-quality PROMs for clinical practice and research. Trial Registration PROSPERO International Prospective Register of Systematic Reviews CRD42020180978; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020180978.

scholarly journals Correlation of Functional Measures of Mobility with Patient-Reported Outcomes after Total Ankle Arthroplasty

2017 ◽  
Vol 2 (2) ◽  
pp. 2473011416S0000
Author(s):  
Justin Kane ◽  
James Brodsky ◽  
Yahya Daoud
Keyword(s):  
Gait Analysis ◽  
Outcome Measures ◽  
Walking Speed ◽  
Step Length ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Sf 36 ◽  
Patient Reported ◽  
Spatial Parameters ◽  
Moderate Positive Correlation

Category: Ankle Introduction/Purpose: Patients undergoing total ankle arthroplasty (TAA) have a proven track record of clinical improvements in subjective patient-reported outcome measures (PROMs) and objective measures with three dimensional gait analysis. Each represents a valid, but different kind of information, and both are important. What is unknown is whether and how objective improvements as measured by gait analysis correlate with the improvements measured by PROMs. The goal of this study was to investigate the correlation between objective function and PROMs in patients undergoing TAA. Methods: Seventy-six patients (28m/48f) aged 61 (37-79) with a mean BMI of 29.60 (19.63-46.64) and greater than 1-year follow-up underwent preoperative and postoperative gait analysis. Temporal-spatial, kinematic, and kinetic parameters of gait were recorded. Patients also completed AOFAS Ankle/Hindfoot scores, visual analog score for pain (VAS), and the MOS 36-Item Short-Form Health Survey (SF-36) questionnaires within two weeks of their preoperative gait analysis and at the one-year postoperative gait analysis. A t-test for dependent means was used to compare preoperative and postoperative outcomes. Additionally, a Pearson correlation coefficient was utilized to measure the strength of association between parameters of gait and PROMs. A p-value of < 0.05 was considered to be statistically significant. Results: Gait Analysis: Patients had a statistically significant improvement in all temporal-spatial parameters of gait, in total range of motion, mean maximum plantarflexion, and ankle power. Patient-reported outcome measures: A statistically significant and clinically meaningful significant improvement was detected for AOFAS score, VAS score, and SF-36-Physical score. Changes in the SF-36-Mental score were not detected to be statistically significant or clinically significant. Correlation: The AOFAS score had a moderate positive correlation with preoperative walking-speed, step-length and ankle-power, postoperative walking-speed, step-length and ankle-power, and improvement in walking-speed, cadence, and ankle-power. The SF-36-Physical score had a weak to moderate positive correlation with preoperative walking speed, step length, and ankle power and postoperative walking speed, step length and ankle power. No correlation between VAS or SF-36-Mental score and function could be detected. Conclusion: There is a moderate correlation with AOFAS and SF-36-Physical scores between walking speed (temporal-spatial parameters), and ankle push-off power (kinetic parameters). PROMs did not correlate with improvements in ROM (kinematic parameters). This may challenge the assumption that preservation of motion is the most important role of TAA. The data may be interpreted to mean cadence, walking-speed, step-length and ankle power are the most important aspects of gait with respect to patients’ perceived outcomes. However, perhaps ROM is important to patient satisfaction – but the outcome measures we use are not sufficiently sensitive/specific to measure the effect of improved or maintained motion.

scholarly journals Haematologists’ experiences implementing patient reported outcome measures (PROMs) in an outpatient clinic: a qualitative study for applied practice

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Stine Thestrup Hansen ◽  
Mette Kjerholt ◽  
Sarah Friis Christensen ◽  
Bibi Hølge-Hazelton ◽  
John Brodersen
Keyword(s):  
Outcome Measures ◽  
Qualitative Methodology ◽  
Symptom Burden ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Outpatient Setting ◽  
Specific Patient ◽  
Individual Interviews ◽  
Individualized Care ◽  
Patient Reported

Abstract Background The patient-doctor relationship is crucial to provide person-centred care, allowing the alleviation of symptom burden caused by disease or treatment. Implementing Patient Reported Outcome Measures (PROMs) is suggested to inform the decision-making process and lead to initiation of care. Yet there are knowledge gaps regarding how meaningful it is to incorporate PROMs in clinical settings. The aim of this study was to investigate haematologists’ experiences when PROMs were implemented in an outpatient setting. Methods Fourteen participant observations, 13 individual interviews and three in-depth interviews were conducted with haematologists, guided by the qualitative methodology Interpretive Description. Analysis was inspired by Habermas’ critical theoretical framework. Results The haematologists included were characterised by dichotomous experiences with PROMs, either resistant to or supporting their implementation. None were observed to elaborate on PROMs during consultations: instead, primary attention was spent discussing the hematological agenda dictated by the system. Conclusion The use of PROMs for individualized care was linked with extensive uncertainties and PROMs were not requested by the haematologists. To improve individualized care, other approaches may be more suitable. If PROMs are to be incorporated into future clinical practice, they should be tested tothe specific patient group and involve relevant users.

scholarly journals A betegek által riportált kimeneti mutatók jelentősége Pompe-kórban

2021 ◽  
Vol 74 (3-4) ◽  
pp. 105-115
Author(s):  
Mária Judit Molnár ◽  
Viktor Molnár ◽  
Izabella László ◽  
Márta Szegedi ◽  
Vera Várhegyi ◽  
...  
Keyword(s):  
Outcome Measures ◽  
Severity Score ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Sf 36 ◽  
Patient Reported ◽  
Fatigue Severity

A modern, betegcentrikus egészségügyi ellátásban a beteg aktivitása, elvárásai, félelmei nagyobb szerepet kapnak a diagnózis gyors felállításának, objektíven mérhető terápiás válasz feltárásának alárendelt, orvoscentrikus információszerzéssel szemben. A krónikus betegségekben elengedhetetlen a betegek gyógyulási folyamatba történő bevonása. A Pompe-betegség egy ritka, örökletes, a lizoszomális tárolási rendellenességek közé tartozó kórkép, amelyben az α-glükozidáz enzimet kódoló gén funkcióvesztő mutációi következtében végtagöv- és axiális típusú izomgyengeség, légzési elégtelenség alakul ki. A betegség felismerésének jelentőségét kiemeli, hogy 15 éve elérhető a hiányzó enzimet a szervezetbe juttató, betegségmoduláló enzimterápia (ERT). Jelen vizsgálatunkban a Pompe-kórban szen­vedő betegek számára készítettünk beteg által riportált kimeneti mutatókat felmérő (PROM) kérdőívcsomagot, amelyben az általános életminőségi skálákat (EuroQoL, EQ-5D, SF-36), a mindennapi tevékenységekhez kapcsolt funkcionális képességeket, a mozgásteljesítményt és a vitalitást felmérő (R-PAct-Scale, Rotterdam és Bartel moz­gás­korlátozottsági skála, Fatigue Severity Score) modulo­kat kombináltuk. Az adatokat három éven át gyűjtöttük. A PROMs kérdőívek (patient reported outcome measures) jól kiegészítik az orvos által rögzített állapotfelmérést, és bizonyos aspektusokról (például a betegek objektív izomgyengeséget meghaladó mértékű fáradékonysága, stagnáló fizikai képességek és aktivitás mellett is romló társadalmi aktivitás, bizonyos doménekben igen jelentős individuális különbségek) csak a PROM-ok nyújtottak információt. A betegségteher pszichés hatásai is tükröződnek a PROM-okban. Az új, innovatív kezelések hatásosságának követésében az orvos által megfigyelt végpontok mellett szükséges a betegek nézőpontjainak figyelembevétele is. A terápiás fejlesztések aktív szereplőivé váló betegek közreműködésével olyan információk nyerhetők, amelyek a reguláris orvosi vizitek alkalmával nem kerülnek felszínre, jóllehet alapvető fontosságúak a klinikai kutatások kérdéseinek és prioritásainak meghatározásában. Minden forgalomban levő orphan gyógyszer vonatkozásában kívánatosnak tartjuk a betegek bevonását az általános és az adott kórképre jellemző állapotleírók többdimenziós gyűjtésébe, azok időbeli változásának követését pedig javasoljuk felhasználni a kezelés hatásosságának monitorozása érdekében.

Relationship of Preoperative Patient-Reported Outcome Measures (PROMs) to Postoperative Success in End-Stage Ankle Arthritis

2019 ◽  
Vol 41 (3) ◽  
pp. 253-258 ◽  
Author(s):  
Feras J. Waly ◽  
Eng Meng Nicholas Yeo ◽  
Kevin J. Wing ◽  
Murray J. Penner ◽  
Andrea Veljkovic ◽  
...  
Keyword(s):  
Outcome Measures ◽  
Short Form ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Ankle Arthritis ◽  
Ankle Osteoarthritis ◽  
Sf 36 ◽  
Patient Reported ◽  
End Stage ◽  
Preoperative Patient

Background: Ankle osteoarthritis is a significant cause of pain and disability. Despite the effectiveness of treatments, a subset of patients remains with persistent pain and functional limitations. The purpose of this study was to use preoperative patient-reported outcome measures to predict which ankle osteoarthritis patients would be most likely to experience postoperative improvements in functional outcomes. Methods: A retrospective analysis of prospectively collected data was used to evaluate 427 patients with end-stage ankle arthritis with 5-year follow-up. Demographics, comorbidities, Ankle Osteoarthritis Scale (AOS), Ankle Arthritis Score (AAS), and the physical and mental component scores of the Short Form–36 (SF-36 Physical Components Score [PCS] and Mental Components Score [MCS]) were collected. The minimal clinically important difference (MCID) was then calculated. Receiver operating characteristic (ROC) analysis was used to choose the optimal threshold values of preoperative patient-reported outcome measure and assess the prediction performance. Results: Patients who scored worst at preoperative baseline made the greatest gains in function and pain relief, and they had a high chance of achieving MCID following surgical treatment. ROC curves demonstrated that preoperative AOS, AAS, and SF-36 PCS and MCS scores were predictive of postoperative improvements in physical and mental function. Patients with preoperative AOS score above 45.7 had an 83% probability of achieving an MCID (AUC = 0.67). Similarly, patients with a preoperative AAS score above 25.7 had a 78% probability of achieving an MCID (AUC = 0.63). Patients with a preoperative SF-36 PCS score below 31 had a 62% probability of achieving an MCID (AUC = 0.64). Patients with a preoperative SF-36 MCS below 52.7 had a 47% probability of achieving an MCID (AUC = 0.89). MCIDs for AOS, AAS, SF3-36 PCS, and SF-36 MCS score changes were 12.4, 10.0, 6.43, and 8.1, respectively. Conclusion: Preoperative patient-reported outcomes measures could predict postoperative improvement in ankle arthritis patients. The results of this study may be used to facilitate discussion between physicians and patients regarding the expected benefit of surgery. Level of Evidence: Level III, prognostic comparative study.

The effectiveness of manipulation of fingers with Dupuytren's contracture 7 days after collagenase clostridial histolyticum injection

2019 ◽  
Vol 45 (3) ◽  
pp. 286-291 ◽  
Author(s):  
Bethany Reynolds ◽  
Vicky Tobin ◽  
Julian A Smith ◽  
Warren M Rozen ◽  
David J. Hunter-Smith
Keyword(s):  
Outcome Measures ◽  
Clinical Success ◽  
Demographic Data ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Extension Deficit ◽  
Level Of Evidence ◽  
Patient Reported ◽  
Collagenase Injection ◽  
Tendon Ruptures

Timing of manipulation of digits after collagenase injection for Dupuytren’s disease varies and often takes place within the first few days post-injection. We prospectively investigated the effectiveness of performing manipulation under local anaesthesia 7 days after injection in 100 patients. Demographic data, passive extension deficit, and patient-reported outcome measures were recorded before collagenase injection. Four to 7 weeks after manipulation, passive extension deficit and patient-reported outcome measures improved significantly without the development of any tendon ruptures. Clinical success was achieved in 41% and clinical improvement in 76% of the patients. Adverse events were reported by 85%. The outcomes were comparable with studies with early manipulation, and demonstrate a safe and effective variation to current protocols. We conclude that delaying manipulation to 7 days after collagenase injection is safe and efficient, which allows for flexibility in clinical appointments without negatively affecting outcome. Level of evidence: III

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