scholarly journals Causes of End Stage Kidney Disease in Maintenance Hemodialysis Patients in District Swat, Khyber Pukhtonkhwa Pakistan

2021 ◽  
Vol 5 (02) ◽  
Author(s):  
Fawad Khalid ◽  
Asad ullah Khan ◽  
Adnan Fazal

Chronic kidney disease (CKD) affects 10–15% of the population worldwide and its prevalence is increasing. Objective: To find the frequency of common diseases causing chronic kidney diseases (CKD) in dialysis dependent patients in District Swat, Khyber Pukhtonkhwa. Methodology: Cross sectional study at Department of Nephrology Nawaz Sharif Kidney Hospital, District Swat, Khyber Pukhtonkhwa, Pakistan. Results: Total of 110 patients were undergoing maintenance hemodialysis. There were 53(48.2%) male and mean age was 54.40+ 16.32 years. Among 110 patients, only 9 (8.2%) had dialysis once per week and 101(91.8%) had dialysis twice per week hemodialysis. Majority, 64(58.2%) patients were undergoing dialysis less than one year. 6(5.5 %) had hypertension, 33(30%) had diabetes and 68(61.8%) patients had both Diabetes and Hypertension. Out of 110, 39(35.5%) patients were Hepatitis B positive, and 28(25.5%) patients had Hepatitis C. Conclusion:  Results of this study showed that the leading cause of chronic kidney disease (CKD) among dialysis patients was diabetes mellitus with or without hypertension and a high prevalence of both HBV and HCV.

2020 ◽  
pp. 75-82
Author(s):  
Minh Nguyen Thanh ◽  
Tam Vo

Objectives: To investigate the correlation between bone density and osteoporosis with some clinical and subclinical factors in patients with dialysis chronic kidney patients. Materials and Methods: Descriptive cross-sectional study, include 163 patients with dialysis chronic kidney disease, from January 2017 to December 2018 at the Department of Haemodyalysis, District 2 Hospital, Ho Chi Minh City. Results: Bone density was negatively correlated with age at the lumbar spine (LS) (r = - 0.225), total hip (total H) (r = - 0.288), femoral neck (FN) (r = - 0.352); with urea at the total H (r = - 0.206), FN (r = - 0.194); with PTH at LS (r = - 0.266), total H (r = - 0.219), FN (r = - 0.168); with β2 Microglobulin at the LS (r = - 0.269). Bone density was positively correlated with glomerular filtration rate at the LS (r = 0.200), FN (r = 0.179); with vitamin D at the LS (r = 0.218) and total H (r = 0.179). Multivariate regression analysis of the risk of decreased bone density at the FN has 2 factors: age (OR = 1.117), PTH (OR = 1.001); at the LS, there are 3 factors: gender (OR = 4.572), PTH (OR=4.078), age (OR = 1.045); at the total H, there are 2 factors: PTH (OR = 3.683), age (OR = 1.117). Osteoporosis in all 3 positions was related to sex (p < 0.05) and age group (p < 0.01). Osteoporosis was associated with PTH, Phosphorus, Aluminum disorders at the FN (p < 0.05), with PTH at the LS (p < 0.05), with PTH, calcium at the total H (p < 0.05). Multivariate regression analysis of the risk of osteoporosis has 3 factors: age (OR = 4.058), PTH (OR = 2.967), female (OR = 2.841). Conclusion: Bone density, osteoporosis is correlated, associated with common factors and factors associated with bone mineral disorders in patients with dialysis chronic kidney disease (CKD - MBD). Key words: End-stage chronic kidney disease, dialysis, bone density


2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Melti Tandi ◽  
Arthur Mongan ◽  
Firginia Manoppo

Abstract: Chronic kidney disease has got a lot of attention and more widely studied despite reached end stage renal failure, patients still live a long life witha fairly good quality of life although the prevalence is increases throughout the year. one of the circumstances in chronic kidney disease is uremia which is a clinical and laboratory syndrome that occurs inorgans. In uremia interference with platelet function, the production ofprostacyclinin blood vesselswould increase, and excessurea levels in blood would be a potential vasodilator and platelet aggregation antagonist. Methods: An analytic observational cross-sectional study. Samples were patients that diagnosed with chronic kidney disease at the Hospital Clinic of Nephrology-Hypertension Prof. Dr.R. D.Kandou Manado in December toFebruary 2014. Criteria included were patients  <80 years old and has been diagnosed with chronic kidney disease in this case had done a physical examination and investigations by doctors, using medical record of urea-creatinine and also a complete blood countand platelet aggregation in Prokita Laboratory Manado. Forstatistical analysisusedShapiro-Wilk testalsoPearsonCorrelationstest. Result: There were 20 patients with chronic kidney disease sampled in this study. It was found that there is a relationship between of urea-creatinine and aggregation results in trace ADP5(P=0.004) while the value ADP10 no significant correlation(P =0.399). Conclusion: In chronic kidney disease patients, urea-creatininewiththe value of platelet aggregation intrace ADP5had a relation ship while intrace ADP10 had not a relationship. Keywords: Chronic kidney disease, platelet aggregation.


2020 ◽  
Vol 28 (1) ◽  
pp. 54-59
Author(s):  
Rafiqul Hasan ◽  
Md Nizamuddin Chowdhury ◽  
Md Nazrul Islam ◽  
Parvez Iftekher Ahmed ◽  
ASM Tanim Anwar ◽  
...  

Background: Pruritus is a common manifestation in patients on hemodialysis. The aim of this study is to determine the distribution of pruritus and evaluate the association between pruritus and serum parathormone levels in chronic kidney disease patients on maintenance haemodialysis. Methods:This analytic, descriptive, cross-sectional study was performed over 191 patients of maintenance haemodialysis in 2014. Information related to the patients including age, gender, residence, pruritus was extracted from questionnaires. Serum levels of intact parathormone were measured & data were analyzed. Results: 68% of the patients had pruritus. The Mean ± SD of serum parathormone was 53.25±7.96 pg/ml in patients with pruritus and 81.91±9.34 pg/ml in patients without pruritus. Our study showed that most patients with pruritus had normal serum parathormone levels and no significant association was found between pruritus and serum parathormone levels. Conclusion: serum parathormone level may not play a role in uraemic pruritus in these patients. J Dhaka Medical College, Vol. 28, No.1, April, 2019, Page 54-59


2014 ◽  
Vol 10 (1) ◽  
pp. 9 ◽  
Author(s):  
Shuchi Anand ◽  
Masuma Khanam ◽  
Juliann Saquib ◽  
Nazmus Saquib ◽  
Tahmeed Ahmed ◽  
...  

2017 ◽  
Vol 5 (1) ◽  
pp. 4 ◽  
Author(s):  
Maisa Elzakil ◽  
Awadia Gareeballah ◽  
Moawia Gameraddin ◽  
Mowada Burai ◽  
Fathelrehman Alagab

Background: Thyroid gland morphology and disorders were affected with chronic kidney diseases (CKD). The study aims to assess thyroid gland disorders and morphology in patients with CKD on regular hemodialysis.Materials and methods: A cross-sectional study included 71 participants divided into two groups. The study group included 51 patients with known chronic kidney disease on hemodialysis and healthy group included 20 participants. The exclusion criteria were thyroid disorders. The thyroid gland was scanned with ultrasound using a 7 MHz probe.Results: The thyroid is enlarged in 21.57% of patients and heterogeneous echotexture in 31.4%. The prevalence of thyroid nodules and cysts were 9.8% and 7.8% respectively. A positive linear correlation existed between duration of hemodialysis and thyroid volume. Thyroid volume and echotexture were significantly increased with duration of hemodialysis (p = .001 and .00 respectively). Thyroid nodules and cysts were not significantly correlated with duration of hemodialysis (p = .06 and .28 respectively).Conclusions: In conclusion, enlargement of thyroid gland and heterogeneity of thyroid tissue were the most common morphological changes in patients with chronic renal failure undergoing hemodialysis. The prevalence increased with longer duration of hemodialysis. Periodic ultrasound assessment of thyroid volume and texture are recommended in hemodialyzed patients to avoid complications.


2015 ◽  
Vol 26 (5) ◽  
pp. 1050 ◽  
Author(s):  
ManjunathJeevanna Kulkarni ◽  
Tukaram Jamale ◽  
NiwruttiK Hase ◽  
PradeepKiggal Jagdish ◽  
Vaibhav Keskar ◽  
...  

2021 ◽  
Vol 5 (4) ◽  
pp. 100-104
Author(s):  
Raheel Ahmed ◽  
Tanveer Ahmed ◽  
Najm Ud Din ◽  
Syed Munib ◽  
Inayat Ur Rehman Inayat Ur Rehman ◽  
...  

Background: Hemodialysis is a well-established replacement therapy for patient with end stage kidney disease havin a great impact on the patient’s quality of life. Therefore, the purpose of this study is to identify the health-related quality of life of patients undergoing maintenance hemodialysis. Methods: A cross sectional single centere survey was carried out from March 2018 to June 2018 at Department of Nephrology, Institute of Kidney diseases, Peshawar in Pakistan. A 36 item KDQOL validated Urdu version was used to identify the quality of life of patients. Results: A total of n=184 patients having chronic kidney disease undergoing hemodialysis participated,of whom 63.6% were males and 57.1% patients were Pashtun. A multiple linear regression showed that patients having kidney disease caused due to hypertension had 45% higher kidney disease component summary (KDCS) score while 16% higher physical component summary (PCS) score and 60% higher mental component summary (MCS) score  and were statistically significant. Similarly; Peshawari patients had 22% lower PCS score as compared to other ethnic groups ; however, in MCS Peshawari patients had 16% higher score  and were statistically significant. Conclusion: The patients have poor quality of life receiving hemodialysis therapy in all three domains like PCS, MCS and KDCS.


2021 ◽  
Vol Volume 14 ◽  
pp. 459-474
Author(s):  
Chiyembekezo Kachimanga ◽  
Anu Jegede Williams ◽  
Musa Bangura ◽  
Marta Lado ◽  
Sahr Kanawa ◽  
...  

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