scholarly journals Uremic Cardiomyopathy

2021 ◽  
Vol 5 (02) ◽  
Author(s):  
Amna Umer ◽  
Muhammad Azhar Waheed Khan ◽  
Maryam Javed ◽  
Azhar Ali Khan
Keyword(s):  
Cardiac Death ◽  
Ventricular Hypertrophy ◽  
Early Stage ◽  
Epidemiological Studies ◽  
Left Ventricular ◽  
Dialysis Patients ◽  
Mortality And Morbidity ◽  
Phosphate Retention ◽  
Uremic Cardiomyopathy ◽  
Event Rates

Chronic Kidney Disease (CKD) affects approximately 10% of the general population. CKD itself is a risk factor for cardiovascular mortality and morbidity. Large epidemiological studies have clearly established a clear relationship between severity of CKD and cardiovascular event rates. Sudden cardiac death accounts for approximately 40% mortality in dialysis patients and it is usually secondary to an underlying cardiomyopathy, with left ventricular hypertrophy mostly evident on echocardiography. Several risk factors play an important role in pathogenesis of uremic cardiomyopathy including vitamin D deficiency, secondary hyperparathyroidism, phosphate retention, increased FGF23 and decreased Klotho levels. The mortality due to cardiovascular events in early stage CKD is relatively higher in comparison to progression to ESRD, so early diagnosis and treatment with dialysis should be focused.

The Clinical Course of Left Ventricular Hypertrophy in Dialysis Patients

Nephron ◽  
1990 ◽  
Vol 55 (2) ◽  
pp. 114-120 ◽  
Author(s):  
Patrick S. Parfrey ◽  
John D. Harriett ◽  
Sheila M. Griffiths ◽  
Rhoda Taylor ◽  
John D. Harnett ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Clinical Course ◽  
Left Ventricular ◽  
Dialysis Patients

Abstract 13820: Diastolic Dysfunction is Not Associated With Increased Diastolic Calcium During Experimental Uremic Cardiomyopathy

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Pamela D Winterberg ◽  
Rong Jiang ◽  
Bo Wang ◽  
Sonal Harbaran ◽  
Mary B Wagner
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Left Ventricular Hypertrophy ◽  
Diastolic Dysfunction ◽  
Ventricular Hypertrophy ◽  
Sarcomere Length ◽  
Treatment Options ◽  
Strain Analysis ◽  
Left Ventricular ◽  
Uremic Cardiomyopathy ◽  
Underlying Mechanisms

Introduction: The underlying mechanisms contributing to uremic cardiomyopathy during chronic kidney disease (CKD) are poorly understood, limiting treatment options. Hypothesis: We aimed to determine if altered calcium (Ca2+) handling in cardiomyocytes contributes to diastolic dysfunction in a mouse model of CKD. Methods: CKD was induced in male 129X1/SvJ mice through five-sixths nephrectomy in a two-stage surgery. Age-matched mice served as controls. Transthoracic echocardiography and speckle-tracking based strain analysis (Vevo2100, VisualSonics, Toronto, Canada) were performed at 8 weeks post-CKD (n=7-8) to assess heart structure and function. Cardiomyocytes isolated from mice with or without CKD (n=3 mice per group, 10-12 cells/mouse) were loaded with Fura 2-AM, paced by field stimulation (1 Hz), and imaged with a dual-excitation fluorescence photomultiplier system (IonOptix Inc, Milton, MA) to measure Ca2+ transients and sarcomere length. Sarcoplasmic reticulum Ca2+ content was determined following rapid application of caffeine.[[Unable to Display Character: &#8232;]] Results: CKD mice displayed left ventricular hypertrophy (LVAW;d 1.46 ± 0.134 vs 1.04 ± 0.129 mm; p<0.001) and decreased longitudinal strain (19 ± 4.1% vs 30 ± 2.3%; p<0.0001) compared to control mice. Resting sarcomere length was significantly shorter in cardiomyocytes isolated from CKD mice compared to normal mice (1.86 ± 0.054 vs 1.89 ± 0.047 nm; p = 0.016), but relaxation time was unchanged (0.21 ± 0.12 vs 0.21 ± 0.15 seconds, p=0.4). Unexpectedly, the baseline cytosolic Ca2+ content was lower in uremic myocytes (1.22 ± 0.353 vs 1.46 ± 0.252 AU, p=0.002). However, the Ca2+ transient amplitude (0.39 ± 0.177 vs 0.41 ± 0.167 AU, p=0.4) and sarcoplasmic reticulum Ca2+ content (1.15 ± 0.321 vs 1.24 ± 0.550 AU, p=0.4) were comparable between CKD and normal cardiomyocytes.[[Unable to Display Character: &#8232;]] Conclusions: Mice with CKD have signs of left ventricular hypertrophy and diastolic dysfunction on echocardiography. Cardiomyocytes isolated from mice with CKD have shorter diastolic sarcomere length implying impaired relaxation, yet paradoxically have decreased diastolic calcium. Thus Ca2+ accumulation during diastole does not appear to contribute to impaired relaxation in this model.

scholarly journals Syphilitic heart - a case report

2013 ◽  
Vol 02 (02) ◽  
pp. 089-092
Author(s):  
K C Jyothi ◽  
Shetty Shailaja ◽  
K C Mahadeva ◽  
M Kapil Dev
Keyword(s):  
Ventricular Hypertrophy ◽  
Left Subclavian Artery ◽  
Left Ventricular ◽  
Ascending Aorta ◽  
Mortality And Morbidity ◽  
Tertiary Syphilis ◽  
Appropriate Treatment ◽  
Male Cadaver ◽  
Great Vessels ◽  
Syphilitic Aortitis

AbstractHeart and its great vessels are involved in tertiary syphilis in the form of syphilitic aortitis often 20 years or more after primary infection is contracted. In a 60 year old male cadaver, we found an enlarged heart with aneurysm of ascending aorta and semilunar septa was found protruding in to the lumen of arch of aorta distal to the origin of left subclavian artery. Right pulmonary vessels were dilated. Right and left atrial cavity were dilated, left ventricular hypertrophy with dilatation was noted. Hispathological findings of the specimens were suggestive of syphilitic aortitis. Cardiovascular syphilis though uncommon is still a significant cause of mortality and morbidity, which can be reduced by adequate screening, accurate diagnosis and appropriate treatment.

scholarly journals Risk of sudden cardiac death in childhood hypertrophic cardiomyopathy: Time to solve the mystery

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Gabrielle Norrish ◽  
Juan Pablo Kaski
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Inborn Errors Of Metabolism ◽  
Ventricular Hypertrophy ◽  
Young Patients ◽  
Left Ventricular ◽  
Inborn Errors ◽  
True Prevalence ◽  
Malformation Syndromes

Hypertrophic cardiomyopathy (HCM) is defined as left ventricular hypertrophy in the absence of loading conditions sufficient to cause the observed abnormality. The true prevalence in childhood is unknown; the aetiology is more heterogeneous than that seen in adult populations, and includes inborn errors of metabolism, malformation syndromes and neuromuscular syndromes. However, one of the greatest clinical challenges in managing young patients with HCM is identifying those at greatest risk of sudden cardiac death.

scholarly journals Practical ways to deal with the high burden of cardiovascular disease in hemodialysis patients

2006 ◽  
Vol 124 (1) ◽  
pp. 36-41 ◽  
Author(s):  
José Jayme Galvão de Lima
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
General Population ◽  
Cardiovascular Risk Factors ◽  
Ventricular Hypertrophy ◽  
Significant Proportion ◽  
Hemodialysis Patients ◽  
Left Ventricular ◽  
Dialysis Patients

Cardiovascular disease is the main cause of death among hemodialysis patients. Although uremia by itself may be considered to be a cardiovascular risk factor, a significant proportion of dialysis patients die because of cardiovascular disease not directly attributable to uremia. Indeed, many of the cardiovascular diseases and cardiovascular risk factors in these patients are common to those occurring in the general population and are amenable to intervention. Lack of proper medical care during the early stages of renal insufficiency and present-day dialysis routines, by failing to correct hypertension, hypervolemia and left ventricular hypertrophy in many patients, may also add to the cardiovascular burden. The author suggests that, in addition to early treatment and referral to a specialist, chronic renal failure patients should undergo intensive cardiovascular screening and treatment, and correction of cardiovascular risk factors based on guidelines established for the general population.

Sex Difference in the Prevalence of Left Ventricular Hypertrophy in Dialysis Patients

2008 ◽  
Vol 29 (5) ◽  
pp. 398-405 ◽  
Author(s):  
Li-Tao Cheng ◽  
Yan-Li Gao ◽  
Jun-Ping Tian ◽  
Yue Gu ◽  
Li Zhang ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Sex Difference ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Dialysis Patients

scholarly journals MELAS Syndrome with Cardiac Involvement: A Multimodality Imaging Approach

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Sara Seitun ◽  
Laura Massobrio ◽  
Anna Rubegni ◽  
Claudia Nesti ◽  
Margherita Castiglione Morelli ◽  
...  
Keyword(s):  
Lactic Acidosis ◽  
Cardiac Death ◽  
Ventricular Hypertrophy ◽  
Cardiac Involvement ◽  
Multimodality Imaging ◽  
Left Ventricular ◽  
Gene Diagnosis ◽  
Cardioverter Defibrillator ◽  
Increased Risk ◽  
Imaging Approach

A 49-year-old man presented with chest pain, dyspnea, and lactic acidosis. Left ventricular hypertrophy and myocardial fibrosis were detected. The sequencing of mitochondrial genome (mtDNA) revealed the presence of A to G mtDNA point mutation at position 3243 (m.3243A>G) in tRNALeu(UUR) gene. Diagnosis of cardiac involvement in a patient with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes syndrome (MELAS) was made. Due to increased risk of sudden cardiac death, cardioverter defibrillator was implanted.

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