Kingella Kingae a Potentially Emerging Pathogen: A Comprehensive Review

2013 ◽  
Author(s):  
Ramana K.V.
Keyword(s):  
Emerging Pathogen ◽  
Kingella Kingae ◽  
Comprehensive Review

scholarly journals Proinflammatory Microenvironment During Kingella kingae Infection Modulates Osteoclastogenesis

2021 ◽  
Vol 12 ◽  
Author(s):  
Ayelén Ivana Pesce Viglietti ◽  
Franco Agustín Sviercz ◽  
Cinthya Alicia Marcela López ◽  
Rosa Nicole Freiberger ◽  
Jorge Quarleri ◽  
...  
Keyword(s):  
Membrane Vesicles ◽  
Outer Membrane Vesicles ◽  
Dependent Manner ◽  
Emerging Pathogen ◽  
Kingella Kingae ◽  
Concentration Dependent Manner ◽  
Inflammatory Microenvironment ◽  
Immune Mediated ◽  
Bone Damage ◽  
Tnf Α

Kingella kingae is an emerging pathogen that causes septic arthritis, osteomyelitis, and bacteremia in children from 6 to 48 months of age. The presence of bacteria within or near the bone is associated with an inflammatory process that results in osteolysis, but the underlying pathogenic mechanisms involved are largely unknown. To determine the link between K. kingae and bone loss, we have assessed whether infection per se or through the genesis of a pro-inflammatory microenvironment can promote osteoclastogenesis. For that purpose, we examined both the direct effect of K. kingae and the immune-mediated mechanism involved in K. kingae-infected macrophage-induced osteoclastogenesis. Our results indicate that osteoclastogenesis is stimulated by K. kingae infection directly and indirectly by fueling a potent pro-inflammatory response that drives macrophages to undergo functional osteoclasts via TNF-α and IL-1β induction. Such osteoclastogenic capability of K. kingae is counteracted by their outer membrane vesicles (OMV) in a concentration-dependent manner. In conclusion, this model allowed elucidating the interplay between the K. kingae and their OMV to modulate osteoclastogenesis from exposed macrophages, thus contributing to the modulation in joint and bone damage.

Kingella kingae: An Emerging Pathogen in Young Children

PEDIATRICS ◽  
2011 ◽  
Vol 127 (3) ◽  
pp. 557-565 ◽  
Author(s):  
P. Yagupsky ◽  
E. Porsch ◽  
J. W. St Geme
Keyword(s):  
Young Children ◽  
Emerging Pathogen ◽  
Kingella Kingae

Virulence determinants of the emerging pathogen Kingella kingae

2020 ◽  
Vol 54 ◽  
pp. 37-42
Author(s):  
Vanessa L Muñoz ◽  
Eric A Porsch ◽  
Joseph W St. Geme
Keyword(s):  
Virulence Determinants ◽  
Emerging Pathogen ◽  
Kingella Kingae

scholarly journals Kingella kingaeCausing Septic Arthritis of the Knee in anImmunocompetentAdult

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
J. Ricketts ◽  
N. N. T. Rehmatullah ◽  
P. Sutton
Keyword(s):  
Septic Arthritis ◽  
Rare Case ◽  
Emerging Pathogen ◽  
Kingella Kingae ◽  
Immunocompetent Adult ◽  
Gram Negative ◽  
Delay In Diagnosis ◽  
Joint Infections ◽  
Isolation Techniques ◽  
Osteoarticular Infections

The bacteriumKingella kingaeis a species of Gram-negative coccobacillus usually found in the oropharynx. This is an emerging pathogen reported to cause bacteraemia, endocarditis, and osteoarticular infections in children and endocarditis in the immunocompromised adult. However, there are few cases of isolated joint infections reported in the immunocompetent adult. Due to specific isolation techniques required, delay in diagnosis can compromise patient outcome. We report a rare case of septic arthritis of the knee in an immunocompetent adult caused byK. kingae.

Comprehensive Review of Psychooncology

1991 ◽  
Vol 36 (6) ◽  
pp. 529-529
Author(s):  
Mary Catherine King
Keyword(s):  
Comprehensive Review

Detection of sensorimotor contingencies in infants before the age of 1 year: A comprehensive review.

2020 ◽  
Vol 56 (7) ◽  
pp. 1233-1251
Author(s):  
Lisa Jacquey ◽  
Jacqueline Fagard ◽  
Rana Esseily ◽  
J. Kevin O'Regan
Keyword(s):  
Comprehensive Review ◽  
Sensorimotor Contingencies
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