scholarly journals Epithelial Transport of Macromolecules: Gastric Mucous Exocytosis

MEMBRANE ◽  
2011 ◽  
Vol 36 (6) ◽  
pp. 286-292
Author(s):  
Takashi Nakahari ◽  
Yukinori Sawabe ◽  
Chikao Shimamoto
Keyword(s):  
Epithelial Transport ◽  
Gastric Mucous ◽  
Transport Of Macromolecules

In Vitro Systems for Studying Epithelial Transport of Macromolecules

2008 ◽  
pp. 151-164 ◽  
Author(s):  
Nicole Daum ◽  
Andrea Neumeyer ◽  
Birgit Wahl ◽  
Michael Bur ◽  
Claus-Michael Lehr
Keyword(s):  
Epithelial Transport ◽  
In Vitro Systems ◽  
Transport Of Macromolecules

Helicobacter pylori infection produces expression of secretory component in gastric mucous cells

2001 ◽  
Vol 120 (5) ◽  
pp. A708-A709
Author(s):  
T KANEKO ◽  
H OTA ◽  
M HAYAMA ◽  
K NAKAJIMA ◽  
A YOSHIZAWA ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Secretory Component ◽  
Helicobacter Pylori Infection ◽  
Mucous Cells ◽  
Gastric Mucous

scholarly journals Efficient aortic lymphatic drainage is necessary for atherosclerosis regression induced by ezetimibe

2020 ◽  
Vol 6 (50) ◽  
pp. eabc2697
Author(s):  
Kim Pin Yeo ◽  
Hwee Ying Lim ◽  
Chung Hwee Thiam ◽  
Syaza Hazwany Azhar ◽  
Caris Tan ◽  
...  
Keyword(s):  
Lymphatic Vessels ◽  
Lymphatic Drainage ◽  
Lymphatic Transport ◽  
Atherosclerotic Plaques ◽  
Tissue Fluid ◽  
Atherosclerosis Progression ◽  
Lymphatic Vasculature ◽  
Lesion Regression ◽  
Transport Of Macromolecules

A functional lymphatic vasculature is essential for tissue fluid homeostasis, immunity, and lipid clearance. Although atherosclerosis has been linked to adventitial lymphangiogenesis, the functionality of aortic lymphatic vessels draining the diseased aorta has never been assessed and the role of lymphatic drainage in atherogenesis is not well understood. We develop a method to measure aortic lymphatic transport of macromolecules and show that it is impaired during atherosclerosis progression, whereas it is ameliorated during lesion regression induced by ezetimibe. Disruption of aortic lymph flow by lymphatic ligation promotes adventitial inflammation and development of atherosclerotic plaque in hypercholesterolemic mice and inhibits ezetimibe-induced atherosclerosis regression. Thus, progression of atherosclerotic plaques may result not only from increased entry of atherogenic factors into the arterial wall but also from reduced lymphatic clearance of these factors as a result of aortic lymph stasis. Our findings suggest that promoting lymphatic drainage might be effective for treating atherosclerosis.

A New Spectrophotometer for Measuring the Spectral Reflectance of Gastric Mucous Membrane

1989 ◽  
Vol 37 (3-4) ◽  
pp. 134-138 ◽  
Author(s):  
Yoichi Miyake ◽  
Takaomi Sekiya ◽  
Tadashi Yano ◽  
Souichi Kubo ◽  
Tadayoshi Hara
Keyword(s):  
Mucous Membrane ◽  
Spectral Reflectance ◽  
Gastric Mucous Membrane ◽  
Gastric Mucous

Effect of sinomenine on thein vitrointestinal epithelial transport of selected compounds

2009 ◽  
pp. n/a-n/a ◽  
Author(s):  
Zhilei Lu ◽  
Weiyang Chen ◽  
Alvaro Viljoen ◽  
Josias H. Hamman
Keyword(s):  
Epithelial Transport

Correlation of Gastric Mucous Volume with Levels of Five Prostaglandins after Gastric Mucosal Injuries by NSAIDs

1990 ◽  
Vol 12 ◽  
pp. S125-S130 ◽  
Author(s):  
Shuji Asada ◽  
Yasuhiro Okumura ◽  
Akio Matsumoto ◽  
Ichiro Hirata ◽  
Saburo Ohshiba
Keyword(s):  
Gastric Mucous

The biosynthesis of glycoconjugates from galactose in the human gastric mucous membrane

1984 ◽  
Vol 32 (3) ◽  
pp. 375-378
Author(s):  
Teresa Kopacz-Jodczyk ◽  
Krzysztof Zwierz ◽  
Władyslaw Gałasinski
Keyword(s):  
Mucous Membrane ◽  
Gastric Mucous Membrane ◽  
Gastric Mucous

scholarly journals Role of the extracellular cAMP-adenosine pathway in renal physiology

2001 ◽  
Vol 281 (4) ◽  
pp. F597-F612 ◽  
Author(s):  
Edwin K. Jackson ◽  
Raghvendra K. Dubey
Keyword(s):  
Adenosine Receptors ◽  
Epithelial Transport ◽  
Receptor Activation ◽  
Hormonal Control ◽  
Renal Physiology ◽  
Tight Coupling ◽  
Extracellular Adenosine ◽  
Mediated Effects ◽  
Extracellular Camp

Adenosine exerts physiologically significant receptor-mediated effects on renal function. For example, adenosine participates in the regulation of preglomerular and postglomerular vascular resistances, glomerular filtration rate, renin release, epithelial transport, intrarenal inflammation, and growth of mesangial and vascular smooth muscle cells. It is important, therefore, to understand the mechanisms that generate extracellular adenosine within the kidney. In addition to three “classic” pathways of adenosine biosynthesis, contemporary studies are revealing a novel mechanism for renal adenosine production termed the “extracellular cAMP-adenosine pathway.” The extracellular cAMP-adenosine pathway is defined as the egress of cAMP from cells during activation of adenylyl cyclase, followed by the extracellular conversion of cAMP to adenosine by the serial actions of ecto-phosphodiesterase and ecto-5′-nucleotidase. This mechanism of extracellular adenosine production may provide hormonal control of adenosine levels in the cell-surface biophase in which adenosine receptors reside. Tight coupling of the site of adenosine production to the site of adenosine receptors would permit a low-capacity mechanism of adenosine biosynthesis to have a large impact on adenosine receptor activation. The purposes of this review are to summarize the physiological roles of adenosine in the kidney; to describe the classic pathways of renal adenosine biosynthesis; to review the evidence for the existence of the extracellular cAMP-adenosine pathway; and to describe possible physiological roles of the extracellular cAMP-adenosine pathway, with particular emphasis on the kidney.

Transdermal Delivery Of Macromolecules Using Nanolipid Carriers

2021 ◽  
Vol 27 ◽  
Author(s):  
Sana Kalave ◽  
Bappaditya Chatterjee ◽  
Parth Shah ◽  
Ambikanandan Misra
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Low Frequency ◽  
Nanostructured Lipid Carriers ◽  
Skin Damage ◽  
Low Frequency Ultrasound ◽  
Transdermal Delivery System ◽  
Nanolipid Carriers ◽  
Transport Of Macromolecules ◽  
Frequency Ultrasound

: Skin being the largest external organ, offers an enticing procedure for transdermal drug delivery, so the drug needs to rise above the outermost layer of the skin, i.e., stratum corneum. Small molecular drug entities obeying the Lipinski rule, i.e., drugs having a molecular weight less than 500Da, high lipophilicity, and optimum polarity, are favored enough to be used on the skin as therapeutics. Skin's barrier action properties prevent the transport of macromolecules at pre-determined therapeutic rates. Notable advancement in macromolecules' transdermal delivery occurred in recent years. Scientists have opted for liposomes, the use of electroporation or, low-frequency ultrasound techniques. Some of these have shown better delivery of macromolecules at clinically beneficial rates. These physical technologies involve complex mechanisms, which may irreversibly incur skin damage. Majorly, two types of lipid-based formulations, including Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) are widely investigated as a transdermal delivery system. In this review, the concepts, mechanisms, and applications of Nanostructured Lipid Carriers that are considered feasible for transporting macromolecules via transdermal delivery system are thoroughly reviewed and presented along with their clinical perspective.

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