scholarly journals Structure and function of glomerular basement membrane.

MEMBRANE ◽  
1989 ◽  
Vol 14 (1) ◽  
pp. 2-10
Author(s):  
Isao EBIHARA ◽  
Hikaru KOIDE
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Structure And Function ◽  
And Function

scholarly journals Hemicentin mediated type IV collagen assembly strengthens juxtaposed basement membrane linkage

2021 ◽  
Author(s):  
Claire A Gianakas ◽  
Daniel P Keeley ◽  
William Ramos-Lewis ◽  
Kieop Park ◽  
Ranjay Jayadev ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Type Iv Collagen ◽  
Fluorescent Proteins ◽  
Structure And Function ◽  
Egg Laying ◽  
Matrix Proteins ◽  
Type Iv ◽  
Seam Cell ◽  
Specialized Form ◽  
And Function

Basement membrane (BM) matrices surround and separate most tissues. However, through poorly understood mechanisms, BMs of adjacent tissues can also stably link to support organ structure and function. Using endogenous knock-in fluorescent proteins, conditional RNAi, optogenetics, and quantitative live imaging, we identified matrix proteins mediating a BM linkage (B-LINK) between the uterine utse and epidermal seam cell BMs in Caenorhabditis elegans that supports the uterus during egg-laying. We found that hemicentin is secreted by the utse and promotes fibulin-1 assembly to jointly initiate the B-LINK. During egg-laying, however, both proteins decline in levels and are not required for B-LINK maintenance. Instead, we discovered that hemicentin also promotes type IV collagen assembly, which accumulates to high levels during egg-laying and sustains the B-LINK during the mechanically active egg-laying period. This work reveals mechanisms underlying BM-BM connection maturation and identifies a crucial function for hemicentin and fibulin-1 in initiating attachment and type IV collagen in strengthening this specialized form of tissue linkage.

Relationship of Muscle Capillary Basement Membrane to Renal Structure and Function in Diabetes Mellitus

Diabetes ◽  
1986 ◽  
Vol 35 (4) ◽  
pp. 421-425 ◽  
Author(s):  
E. N. Ellis ◽  
S. M. Mauer ◽  
F. C. Goetz ◽  
D. E. R. Sutherland ◽  
M. W. Steffes
Keyword(s):  
Diabetes Mellitus ◽  
Basement Membrane ◽  
Structure And Function ◽  
Capillary Basement Membrane ◽  
Renal Structure ◽  
And Function ◽  
Relationship Of

Structure and Function of Basement Membrane.

1982 ◽  
Vol 79 (s1) ◽  
pp. 69s-72s ◽  
Author(s):  
John R. Stanley ◽  
David T. Woodley ◽  
Stephen I. Katz ◽  
George R. Martin
Keyword(s):  
Basement Membrane ◽  
Structure And Function ◽  
And Function

scholarly journals Structure and Function of Basement Membrane

1982 ◽  
Vol 79 (1) ◽  
pp. 69-72 ◽  
Author(s):  
John R. Stanley ◽  
David T. Woodley ◽  
Stephen I. Katz ◽  
George R. Martin
Keyword(s):  
Basement Membrane ◽  
Structure And Function ◽  
And Function

Structure and Function of Basement Membrane Proteoglycans

2007 ◽  
pp. 189-203 ◽  
Author(s):  
Mats Paulsson ◽  
Sakuhei Fujiwara ◽  
Marie Dziadek ◽  
Rupert Timpl ◽  
Gunnar Pejler ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Structure And Function ◽  
And Function

scholarly journals Matrix Metalloproteinase 9 Protects Mice from Anti–Glomerular Basement Membrane Nephritis through Its Fibrinolytic Activity

2001 ◽  
Vol 193 (7) ◽  
pp. 793-802 ◽  
Author(s):  
Brigitte Lelongt ◽  
Soraya Bengatta ◽  
Madeleine Delauche ◽  
Leif R. Lund ◽  
Zena Werb ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Matrix Metalloproteinase ◽  
Glomerular Basement Membrane ◽  
Glomerular Injury ◽  
Important Mediator ◽  
Renal Histology ◽  
Glomerular Lesions ◽  
And Function ◽  
Old Mice ◽  
Metalloproteinase 9

Matrix metalloproteinase (MMP)9/gelatinase B is increased in various nephropathies. To investigate its role, we used a genetic approach. Adult MMP9-deficient (MMP9−/−) mice showed normal renal histology and function at 3 mo. We investigated the susceptibility of 3-mo-old mice to the accelerated model of anti-glomerular basement membrane nephritis, in which fibrin is an important mediator of glomerular injury and renal impairment. Unexpectedly, nephritis was more severe in MMP9−/− than in control mice, as attested by levels of serum creatinine and albuminuria, and the extent of crescents and fibrin deposits. Circulating or deposited immunoglobulin G, interleukin (IL)-1β, or IL-10 were the same in MMP9−/− and MMP9+/+ mice. However, we found that fibrin is a critical substrate for MMP9, and in its absence fibrin accumulated in the glomeruli. These data indicate that MMP9 is required for a novel protective effect on the development of fibrin-induced glomerular lesions.

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