Does an Asian Natricine Snake, Rhabdophis tigrinus, Have Chemical Preference for a Skin Toxin of Toads?

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Masaya Fukuda ◽  
Akira Mori
Keyword(s):  
Rhabdophis Tigrinus

scholarly journals Attempt to Develop Rat Disseminated Intravascular Coagulation Model Using Yamakagashi (Rhabdophis tigrinus) Venom Injection

Toxins ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 160
Author(s):  
Akihiko Yamamoto ◽  
Takashi Ito ◽  
Toru Hifumi
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Clinical Condition ◽  
Underlying Disease ◽  
Fibrinogen Concentration ◽  
Blood Coagulation Factors ◽  
Fixed Amount ◽  
Intravascular Coagulation ◽  
Measurement Limit ◽  
Human Pathology ◽  
Rhabdophis Tigrinus

Disseminated intravascular coagulation, a severe clinical condition caused by an underlying disease, involves a markedly continuous and widespread activation of coagulation in the circulating blood and the formation of numerous microvascular thrombi. A snakebite, including that of the Yamakagashi (Rhabdophis tigrinus), demonstrates this clinical condition. Thus, an animal model using Yamakagashi venom was constructed. Yamakagashi venom was administered to rats, and its lethality and the changes in blood coagulation factors were detected after venom injection. When 300 μg venom was intramuscularly administered to 12-week-old rats, (1) they exhibited hematuria with plasma hemolysis and died within 48 h; (2) Thrombocytopenia in the blood was observed in the rats; (3) irreversible prolongation of prothrombin time in the plasma to the measurement limit occurred; (4) fibrinogen concentration in the plasma irreversibly decreased below the measurement limit; and (5) A transient increase in the plasma concentration of D-dimer was observed. In this model, a fixed amount of Rhabdophis tigrinus venom injection resulted in the clinical symptom similar to the human pathology with snakebite. The use of the rat model is very effective in validating the therapeutic effect of human disseminated intravascular coagulation condition due to snakebite.

Maternal provisioning of sequestered defensive steroids by the Asian snake Rhabdophis tigrinus

Chemoecology ◽  
2008 ◽  
Vol 18 (3) ◽  
pp. 181-190 ◽  
Author(s):  
Deborah A. Hutchinson ◽  
Alan H. Savitzky ◽  
Akira Mori ◽  
Jerrold Meinwald ◽  
Frank C. Schroeder
Keyword(s):  
Maternal Provisioning ◽  
Rhabdophis Tigrinus

scholarly journals Toxin ophthalmia caused by nuchal gland secretion of the Taiwan tiger keelback (Rhabdophis tigrinus formosanus)

2014 ◽  
Vol 113 (10) ◽  
pp. 750-753 ◽  
Author(s):  
Yen-Chia Chen ◽  
David Hung-Tsang Yen ◽  
Yen-Wen Chen ◽  
Mu-Shung Huang ◽  
Chun-I. Huang ◽  
...  
Keyword(s):  
Gland Secretion ◽  
Rhabdophis Tigrinus
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