Design, synthesis and spectroscopic studies of amphiphilic platinum(II) complexes with tridentate N-donor ligands : from simple molecules to supramolecular assemblies and nanostructures

2014 ◽  
Author(s):  
Charlotte Po
Keyword(s):  
Spectroscopic Studies ◽  
Supramolecular Assemblies ◽  
Donor Ligands ◽  
Design Synthesis ◽  
Simple Molecules

The Construction of New Proteins. II. Design, Synthesis and Conformational Studies of Folding Units with βαβ-Topology

1986 ◽  
Vol 41 (10) ◽  
pp. 1315-1322 ◽  
Author(s):  
Manfred Mutter ◽  
Karl-Heinz Altmann ◽  
Thomas Vorherr
Keyword(s):  
Solid Phase ◽  
Three Dimensional ◽  
Chemical Properties ◽  
Spectroscopic Studies ◽  
General Concept ◽  
Dimensional Structure ◽  
Design Synthesis ◽  
Phase Synthesis ◽  
Conformational Studies ◽  
Conformational Effects

The design, synthesis and preliminary conformational studies of two polypeptides exhibiting βαβ-type folding topologies are presented. In the design of the model peptides the general concept for the construction of new proteins developed in the preceeding paper was applied. According to this strategy, amphiphilic helices and β-sheets are linked together via hydrophilic loops to attain three-dimensional structures of higher order (‘supersecondary structures’). Com­puter-assisted molecular modelling served as a valuable tool for minimizing conformational con­straints within the molecules. The 38-residue peptide MI was synthesized using polyethylene glycol (PEG) as solubilizing polymeric support (‘Liquid-Phase synthesis'). Conformationally in­duced changes in the physico-chemical properties of the growing peptide chain stressed the significance of conformational effects in peptide synthesis reported earlier. Similar observations were made during the solid-phase synthesis of the 35-peptide MII. CD and IR spectroscopic studies revealed a high degree of secondary structure for both folding units. The present data strongly support the adoption of a three-dimensional structure for both models.

scholarly journals Syntheses, Characterization, Thermal, and Antimicrobial Studies of Lanthanum(III) Tolyl/Benzyldithiocarbonates

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Savit Andotra ◽  
Nidhi Kalgotra ◽  
Sushil K. Pandey
Keyword(s):  
Antibacterial Activity ◽  
Heteronuclear Nmr ◽  
Spectroscopic Studies ◽  
Donor Ligands ◽  
Molar Ratio ◽  
Nitrogen And Phosphorus ◽  
Antimicrobial Studies ◽  
Elemental Analyses ◽  
Lanthanum Atom ◽  
Bidentate Mode

Lanthanum(III) tris(O-tolyl/benzyldithiocarbonates), [La(ROCS2)] (R =o-,m-,p-CH3C6H4and C6H5CH2), were isolated as yellow solid by the reaction of LaCl3·7H2O with sodium salt of tolyl/benzyldithiocarbonates, ROCS2Na (R =o-,m-,p-CH3C6H4and C6H5CH2), in methanol under anhydrous conditions in 1 : 3 molar ratio. These complexes have formed adducts with nitrogen and phosphorus donor molecules by straightforward reaction of these complexes with donor ligands, which have the composition of the type [La(ROCS2)3·nL] (where n = 2, L = NC5H5or P(C6H5)3and n = 1, L = N2C12H8or N2C10H8). Elemental analyses, mass, IR, TGA, and heteronuclear NMR (1H,13C and31P) spectroscopic studies indicated bidentate mode of bonding by dithiocarbonate ligands leading to hexacoordinated and octacoordinated geometry around the lanthanum atom. Antimicrobial (antifungal and antibacterial) activity of the free ligands and some of the complexes have also been investigated which exhibited significantly more activity for the complexes than the free ligands.

Synthesis and spectroscopic studies of organometallic Mn(I) complexes containing the novel mixed donor ligands 2-{MeSeCH(2−n)(SiMe3)n}C5H4N (n=0–2)

2003 ◽  
Vol 674 (1-2) ◽  
pp. 38-44 ◽  
Author(s):  
Brian W Skelton ◽  
Vicki-Anne Tolhurst ◽  
Allan H White ◽  
Alan M Williams ◽  
Adele J Wilson
Keyword(s):  
Spectroscopic Studies ◽  
Donor Ligands ◽  
The Novel
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