Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma

2015 ◽  
Author(s):  
Sitian Yang
Keyword(s):  
Hepatocellular Carcinoma ◽  
End Joining ◽  
Drug Induced ◽  
Non Homologous End Joining

scholarly journals The role of RecQ helicases in non-homologous end-joining

2014 ◽  
Vol 49 (6) ◽  
pp. 463-472 ◽  
Author(s):  
Guido Keijzers ◽  
Scott Maynard ◽  
Raghavendra A. Shamanna ◽  
Lene Juel Rasmussen ◽  
Deborah L. Croteau ◽  
...  
Keyword(s):  
End Joining ◽  
Recq Helicases ◽  
Non Homologous End Joining

The role of the non-homologous end-joining pathway in lymphocyte development

2004 ◽  
Vol 200 (1) ◽  
pp. 115-131 ◽  
Author(s):  
Sean Rooney ◽  
Jayanta Chaudhuri ◽  
Frederick W. Alt
Keyword(s):  
Lymphocyte Development ◽  
End Joining ◽  
Non Homologous End Joining

scholarly journals Loss of Cdc13 causes genome instability by a deficiency in replication-dependent telomere capping

2019 ◽  
Author(s):  
Rachel E Langston ◽  
Dominic Palazzola ◽  
Erin Bonnell ◽  
Raymund J. Wellinger ◽  
Ted Weinert
Keyword(s):  
Homologous Recombination ◽  
Genome Stability ◽  
Genome Instability ◽  
Chromosome Instability ◽  
S Phase ◽  
Temperature Sensitive ◽  
End Joining ◽  
Telomere Capping ◽  
Non Homologous End Joining

AbstractIn budding yeast, Cdc13, Stn1, and Ten1 form a telomere binding heterotrimer dubbed CST. Here we investigate the role of Cdc13/CST in maintaining genome stability, using a Chr VII disome system that can generate recombinants, loss, and enigmatic unstable chromosomes. In cells expressing a temperature sensitive CDC13 allele, cdc13F684S, unstable chromosomes frequently arise due to problems in or near a telomere. Hence, when Cdc13 is defective, passage through S phase causes Exo1-dependent ssDNA and unstable chromosomes, which then are the source for whole chromosome instability events (e.g. recombinants, chromosome truncations, dicentrics, and/or loss). Specifically, genome instability arises from a defect in Cdc13’s replication-dependent telomere capping function, not Cdc13s putative post-replication telomere capping function. Furthermore, the unstable chromosomes form without involvement of homologous recombination nor non-homologous end joining. Our data suggest that a Cdc13/CST defect in semi-conservative replication near the telomere leads to ssDNA and unstable chromosomes, which then are lost or subject to complex rearrangements. This system defines a links between replication-dependent chromosome capping and genome stability in the form of unstable chromosomes.

The role of BRCA1 in non-homologous end-joining

2006 ◽  
Vol 240 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Da-Tian Bau ◽  
Yi-Chien Mau ◽  
Chen-Yang Shen
Keyword(s):  
End Joining ◽  
Non Homologous End Joining

One ring to bring them all—The role of Ku in mammalian non-homologous end joining

DNA Repair ◽  
2014 ◽  
Vol 17 ◽  
pp. 30-38 ◽  
Author(s):  
Gabrielle J. Grundy ◽  
Hayley A. Moulding ◽  
Keith W. Caldecott ◽  
Stuart L. Rulten
Keyword(s):  
End Joining ◽  
Non Homologous End Joining
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