The role of nutrient pathway in lumbar intervertebral disc allograft after transplantation

2014 ◽  
Author(s):  
Yongcan Huang
Keyword(s):  
Intervertebral Disc ◽  
Lumbar Intervertebral Disc

The role of the nucleus pulposus in neutral zone human lumbar intervertebral disc mechanics

2008 ◽  
Vol 41 (10) ◽  
pp. 2104-2111 ◽  
Author(s):  
Marco Cannella ◽  
Amy Arthur ◽  
Shanee Allen ◽  
Michael Keane ◽  
Abhijeet Joshi ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Neutral Zone ◽  
Lumbar Intervertebral Disc

scholarly journals A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Chris Daly ◽  
Peter Ghosh ◽  
Graham Jenkin ◽  
David Oehme ◽  
Tony Goldschlager
Keyword(s):  
Back Pain ◽  
Animal Models ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Discogenic Pain ◽  
Lumbar Intervertebral Disc ◽  
Large Size ◽  
Testing Potential

Lower back pain is the leading cause of disability worldwide. Discogenic pain secondary to intervertebral disc degeneration is a significant cause of low back pain. Disc degeneration is a complex multifactorial process. Animal models are essential to furthering understanding of the degenerative process and testing potential therapies. The adult human lumbar intervertebral disc is characterized by the loss of notochordal cells, relatively large size, essentially avascular nature, and exposure to biomechanical stresses influenced by bipedalism. Animal models are compared with regard to the above characteristics. Numerous methods of inducing disc degeneration are reported. Broadly these can be considered under the categories of spontaneous degeneration, mechanical and structural models. The purpose of such animal models is to further our understanding and, ultimately, improve treatment of disc degeneration. The role of animal models of disc degeneration in translational research leading to clinical trials of novel cellular therapies is explored.

The Mechanical Role of the Radial Fiber Network Within the Annulus Fibrosus of the Lumbar Intervertebral Disc: A Finite Elements Study

2018 ◽  
Vol 141 (2) ◽  
Author(s):  
Mirit Sharabi ◽  
Aviad Levi-Sasson ◽  
Roza Wolfson ◽  
Kelly R. Wade ◽  
Fabio Galbusera ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Annulus Fibrosus ◽  
Local Stress ◽  
Element Model ◽  
Collagen Fibers ◽  
Lumbar Intervertebral Disc ◽  
Fiber Network ◽  
Radial Fiber ◽  
The Matrix

The annulus fibrosus (AF) of the intervertebral disc (IVD) consists of a set of concentric layers composed of a primary circumferential collagen fibers arranged in an alternating oblique orientation. Moreover, there exists an additional secondary set of radial translamellar collagen fibers which connects the concentric layers, creating an interconnected fiber network. The aim of this study was to investigate the mechanical role of the radial fiber network. Toward that goal, a three-dimensional (3D) finite element model of the L3–L4 spinal segment was generated and calibrated to axial compression and pure moment loading. The AF model explicitly recognizes the two heterogeneous networks of fibers. The presence of radial fibers demonstrated a pronounced effect on the local disc responses under lateral bending, flexion, and extension modes. In these modes, the radial fibers were in a tensile state in the disc region that subjected to compression. In addition, the circumferential fibers, on the opposite side of the IVD, were also under tension. The local stress in the matrix was decreased in up to 9% in the radial fibers presence. This implies an active fiber network acting collectively to reduce the stresses and strains in the AF lamellae. Moreover, a reduction of 26.6% in the matrix sideways expansion was seen in the presence of the radial fibers near the neutral bending axis of the disc. The proposed biomechanical model provided a new insight into the mechanical role of the radial collagen fibers in the AF structure. This model can assist in the design of future IVD substitutes.

scholarly journals Intervertebral Disc and Adipokine Leptin—Loves Me, Loves Me Not

2020 ◽  
Vol 22 (1) ◽  
pp. 375
Author(s):  
Goran Curic
Keyword(s):  
Adipose Tissue ◽  
Intervertebral Disc ◽  
Nutrient Deficiency ◽  
Protective Role ◽  
Lumbar Intervertebral Disc ◽  
Metabolic Role ◽  
Ivd Degeneration ◽  
Negative Connotation

Leptin—the most famous adipose tissue-secreted hormone—in the human body is mostly observed in a negative connotation, as the hormone level increases with the accumulation of body fat. Nowadays, fatness is becoming another normal body shape. Fatness is burdened with numerous illnesses—including low back pain and degenerative disease of lumbar intervertebral disc (IVD). IVD degeneration and IVD inflammation are two indiscerptible phenomena. Irrespective of the underlying pathophysiological background (trauma, obesity, nutrient deficiency), the inflammation is crucial in triggering IVD degeneration. Leptin is usually depicted as a proinflammatory adipokine. Many studies aimed at explaining the role of leptin in IVD degeneration, though mostly in in vitro and on animal models, confirmed leptin’s “bad reputation”. However, several studies found that leptin might have protective role in IVD metabolism. This review examines the current literature on the metabolic role of different depots of adipose tissue, with focus on leptin, in pathogenesis of IVD degeneration.

scholarly journals Role of the miR-133a-5p/FBXO6 axis in the regulation of intervertebral disc degeneration

2021 ◽  
Vol 29 ◽  
pp. 123-133
Author(s):  
Xian-Fa Du ◽  
Hai-Tao Cui ◽  
He-Hai Pan ◽  
Jun Long ◽  
Hao-Wen Cui ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration
Sign in / Sign up

Export Citation Format

Share Document