Role of double-stranded RNA-binding protein PACT in MDA5-mediated antiviral innate immune response

2014 ◽  
Author(s):  
Pak-yin Lui
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Innate Immune ◽  
Double Stranded Rna

scholarly journals The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Chen Li ◽  
Lu Feng ◽  
Wei-Wei Luo ◽  
Cao-Qi Lei ◽  
Mi Li ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Adaptor Protein ◽  
Antiviral Response ◽  
Innate Immune ◽  
Innate Antiviral Response ◽  
Hsv 1

AbstractMITA (also known as STING) is an ER-located adaptor protein, which mediates DNA-triggered innate immune response and is critically involved in autoimmune diseases and tumorigenesis. MITA is regulated by post-translational modifications, but how post-transcriptional mechanisms are involved in the regulation of MITA is still largely unknown. Here, we identified the RNA-binding protein LUC7L2 as a negative regulator of DNA virus-triggered innate immune response. LUC7L2-deficient mice exhibited resistance to lethal herpes simplex virus 1 (HSV-1) infection and reduced HSV-1 loads in the brain. Mechanistically, LUC7L2 directly bound to intron 3 of MITA precursor messenger RNA, inhibited its splicing and promoted its nonsense-mediated decay, leading to its downregulation at protein level. LUC7L2-deficient cells had markedly increased MITA level, leading to heightened innate antiviral response. Finally, LUC7L2 was induced following HSV-1 infection. Our findings reveal a feedback negative post-transcriptional regulatory mechanism for regulation of MITA-mediated innate immune response to viral and aberrant cellular DNA.

scholarly journals Tristetraprolin prevents gastric metaplasia in mice by suppressing pathogenic inflammation

2021 ◽  
Author(s):  
Jonathan T. Busada ◽  
Stuti Kadka ◽  
Kylie N. Peterson ◽  
Deborah J. Stumpo ◽  
Lecong Zhou ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Immune Activation ◽  
Rna Binding ◽  
Rna Binding Protein ◽  
Innate Immune ◽  
Cancer Development ◽  
Expression Of Genes ◽  
Gastric Metaplasia ◽  
Spasmolytic Polypeptide

AbstractAberrant immune activation is associated with numerous inflammatory and autoimmune diseases and contributes to cancer development and progression. Within the stomach, inflammation drives a well-established sequence from gastritis to metaplasia, eventually resulting in adenocarcinoma. Unfortunately, the processes that regulate gastric inflammation and prevent carcinogenesis remain unknown. Tristetraprolin (TTP) is an RNA-binding protein that promotes the turnover of numerous pro-inflammatory and oncogenic mRNAs. Here, we utilized a TTP-overexpressing model, the TTPΔARE mouse, to examine whether TTP can protect the stomach from adrenalectomy (ADX)-induced gastric inflammation and spasmolytic polypeptide-expressing metaplasia (SPEM). We found that TTPΔARE mice were completely protected from ADX-induced gastric inflammation and SPEM. RNA sequencing revealed that TTP overexpression suppressed the expression of genes associated with the innate immune response. Finally, we show that protection from gastric inflammation was only partially due to suppression of Tnf, a well-known TTP target. Our results demonstrate that TTP exerts broad anti-inflammatory effects in the stomach and suggest that therapies that increase TTP expression may be effective treatments of pro-neoplastic gastric inflammation.

scholarly journals A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing

2006 ◽  
Vol 103 (15) ◽  
pp. 5823-5828 ◽  
Author(s):  
T. M. Rowe ◽  
M. Rizzi ◽  
K. Hirose ◽  
G. A. Peters ◽  
G. C. Sen
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Double Stranded Rna ◽  
Ear Development ◽  
Mouse Ear

scholarly journals The role of beneficial bacteria wall elasticity in regulating innate immune response

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Viktoria V. Мokrozub ◽  
Liudmyla M. Lazarenko ◽  
Liubov M. Sichel ◽  
Lidia P. Babenko ◽  
Petro M. Lytvyn ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Beneficial Bacteria
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