Budget-sensitive testing and analysis strategies and their applications to concurrent and service-based systems

2013 ◽  
Author(s):  
Ke Zhai
Keyword(s):  
Analysis Strategies ◽  
Sensitive Testing

Differential Drug Target Selection in Blood Coagulation: What can we get from Computational Systems Biology Models?

2020 ◽  
Vol 26 (18) ◽  
pp. 2109-2115 ◽  
Author(s):  
Mikhail A. Panteleev ◽  
Anna A. Andreeva ◽  
Alexey I. Lobanov
Keyword(s):  
Blood Coagulation ◽  
Biological Network ◽  
Target Selection ◽  
Anticoagulation Therapy ◽  
Differential Regulation ◽  
Coagulation Cascade ◽  
Computational Systems Biology ◽  
Analysis Strategies ◽  
Optimal Target ◽  
Computational Systems

Discovery and selection of the potential targets are some of the important issues in pharmacology. Even when all the reactions and the proteins in a biological network are known, how does one choose the optimal target? Here, we review and discuss the application of the computational methods to address this problem using the blood coagulation cascade as an example. The problem of correct antithrombotic targeting is critical for this system because, although several anticoagulants are currently available, all of them are associated with bleeding risks. The advantages and the drawbacks of different sensitivity analysis strategies are considered, focusing on the approaches that emphasize: 1) the functional modularity and the multi-tasking nature of this biological network; and 2) the need to normalize hemostasis during the anticoagulation therapy rather than completely suppress it. To illustrate this effect, we show the possibility of the differential regulation of lag time and endogenous thrombin potential in the thrombin generation. These methods allow to identify the elements in the blood coagulation cascade that may serve as the targets for the differential regulation of this system.

scholarly journals Predictors of Successful Reading Comprehension in Bilingual Adults: The Role of Reading Strategies and Language Proficiency

Languages ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 18
Author(s):  
Deanna C. Friesen ◽  
Bailey Frid
Keyword(s):  
Reading Comprehension ◽  
Language Proficiency ◽  
Text Analysis ◽  
Reading Strategies ◽  
Background Knowledge ◽  
Strategy Use ◽  
Dominant Language ◽  
Analysis Strategies

The current study investigated the type of strategies that English–French bilingual adults utilize when reading in their dominant and non-dominant languages and which of these strategies are associated with reading comprehension success. Thirty-nine participants read short texts while reporting aloud what they were thinking as they read. Following each passage, readers answered three comprehension questions. Questions either required information found directly in the text (literal question) or required a necessary inference or an elaborative inference. Readers reported more necessary and elaborative inferences and referred to more background knowledge in their dominant language than in their non-dominant language. Engaging in both text analysis strategies and meaning extraction strategies predicted reading comprehension success in both languages, with differences observed depending on the type of question posed. Results are discussed with respect to how strategy use supports the development of text representations.

NOTE ON THE MEASUREMENT OF y-DEPENDENCE IN NEUTRINO-ELECTRON SCATTERING: A SENSITIVE TEST OF THE STANDARD MODEL

1993 ◽  
Vol 02 (04) ◽  
pp. 915-921 ◽  
Author(s):  
C. RANGACHARYULU ◽  
A. RICHTER
Keyword(s):  
Standard Model ◽  
Differential Cross Section ◽  
Cross Section ◽  
Electron Scattering ◽  
Differential Cross ◽  
Sensitive Test ◽  
Testing Ground ◽  
The Standard Model ◽  
Sensitive Testing

It is pointed out that the y-dependence of the differential cross-section for various types of neutrinos on the electron promises to be a sensitive testing ground of the electroweak Standard Model at KAON in Vancouver. Estimates of the flux requirements are given and the feasibility of such experiments is discussed.

Efficient Analysis of a Catenary Riser

2006 ◽  
Author(s):  
Elizabeth Passano ◽  
Carl M. Larsen
Keyword(s):  
Operating Conditions ◽  
Stochastic Simulations ◽  
Worst Case ◽  
Nonlinear Structure ◽  
Tension Response ◽  
Extreme Response ◽  
Analysis Strategies ◽  
Low Tension ◽  
Term Response

The paper deals with the challenge of predicting the extreme response of catenary risers, a topic of both industry and academic interest. Large heave motions introduced at the upper end of a catenary riser can lead to compression and large bending moments in the region immediately above the touch down area. In the worst case, dynamic beam buckling may occur. The focus of the paper will be on understanding the riser behaviour in extreme, low-tension response and in establishing suitable analysis strategies to predict the extreme response. Results from long nonlinear stochastic simulations of many sea states with varying environmental and operating conditions may be combined to describe the long-term response of a nonlinear structure such as a catenary riser. However, this theoretically straight-forward approach is very demanding computationally and ways to limit the extent of nonlinear stochastic simulations are therefore sought. The usefulness of simpler methods such as regular wave analysis to improve understanding of the physical behaviour and to aid in concentrating the nonlinear simulations to where they are most useful, will be demonstrated.

scholarly journals Multivariate analysis strategies for processing ToF-SIMS images of biomaterials

Biomaterials ◽  
2007 ◽  
Vol 28 (15) ◽  
pp. 2412-2423 ◽  
Author(s):  
B TYLER ◽  
G RAYAL ◽  
D CASTNER
Keyword(s):  
Multivariate Analysis ◽  
Tof Sims ◽  
Analysis Strategies
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