The role of silver nanoparticles on skin wound healing, tissue remodeling and their potential cytotoxicity

2013 ◽  
Author(s):  
Xuelai Liu
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Tissue Remodeling ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Healing Tissue

scholarly journals Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration

2019 ◽  
Vol 7 ◽  
Author(s):  
Peng Hu ◽  
Qinxin Yang ◽  
Qi Wang ◽  
Chenshuo Shi ◽  
Dali Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Messenger Rna ◽  
Cell Types ◽  
Skin Wound ◽  
Effector Proteins ◽  
Skin Wound Healing ◽  
New Research

Abstact Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types, growth factors, extracellular matrix (ECM), nerves, and blood vessels. Mesenchymal stromal cells (MSCs) take part in all the skin wound healing stages playing active and beneficial roles in animal models and humans. Exosomes, which are among the key products MSCs release, mimic the effects of parental MSCs. They can shuttle various effector proteins, messenger RNA (mRNA) and microRNAs (miRNAs) to modulate the activity of recipient cells, playing important roles in wound healing. Moreover, using exosomes avoids many risks associated with cell transplantation. Therefore, as a novel type of cell-free therapy, MSC-exosome -mediated administration may be safer and more efficient than whole cell. In this review, we provide a comprehensive understanding of the latest studies and observations on the role of MSC-exosome therapy in wound healing and cutaneous regeneration. In addition, we address the hypothesis of MSCs microenvironment extracellular vesicles (MSCs-MEVs) or MSCs microenvironment exosomes (MSCs-MExos) that need to take stock of and solved urgently in the related research about MSC-exosomes therapeutic applications. This review can inspire investigators to explore new research directions of MSC-exosome therapy in cutaneous repair and regeneration.

scholarly journals The Role of Stem Cells During Scarless Skin Wound Healing

2014 ◽  
Vol 3 (4) ◽  
pp. 304-314 ◽  
Author(s):  
Michael Sung-Min Hu ◽  
Robert C. Rennert ◽  
Adrian McArdle ◽  
Michael T. Chung ◽  
Graham G. Walmsley ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Skin Wound ◽  
Skin Wound Healing

scholarly journals Role of carbonic anhydrases in skin wound healing

2017 ◽  
Vol 49 (5) ◽  
pp. e334-e334 ◽  
Author(s):  
Harlan Barker ◽  
Marleena Aaltonen ◽  
Peiwen Pan ◽  
Maria Vähätupa ◽  
Pirkka Kaipiainen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Carbonic Anhydrases ◽  
Skin Wound Healing

scholarly journals Role of periostin in skin wound healing and pathologic scar formation

2020 ◽  
Vol 133 (18) ◽  
pp. 2236-2238
Author(s):  
Shi-Lu Yin ◽  
Ze-Lian Qin ◽  
Xin Yang
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Scar Formation ◽  
Skin Wound Healing

scholarly journals Silver Nanoparticles Mediate Differential Responses in Keratinocytes and Fibroblasts during Skin Wound Healing

ChemMedChem ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. 468-475 ◽  
Author(s):  
Xuelai Liu ◽  
Pui-yan Lee ◽  
Chi-ming Ho ◽  
Vincent C. H. Lui ◽  
Yan Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Differential Responses

scholarly journals New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing

Antibiotics ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1377
Author(s):  
Oriana Simonetti ◽  
Giulio Rizzetto ◽  
Giulia Radi ◽  
Elisa Molinelli ◽  
Oscar Cirioni ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Skin Infections ◽  
Skin Wound Healing ◽  
Quorum Sensing Inhibitors ◽  
Therapeutic Choice ◽  
Staphylococcal Skin Infections

Among the most common complications of both chronic wound and surgical sites are staphylococcal skin infections, which slow down the wound healing process due to various virulence factors, including the ability to produce biofilms. Furthermore, staphylococcal skin infections are often caused by methicillin-resistant Staphylococcus aureus (MRSA) and become a therapeutic challenge. The aim of this narrative review is to collect the latest evidence on old and new anti-staphylococcal therapies, assessing their anti-biofilm properties and their effect on skin wound healing. We considered antibiotics, quorum sensing inhibitors, antimicrobial peptides, topical dressings, and antimicrobial photo-dynamic therapy. According to our review of the literature, targeting of biofilm is an important therapeutic choice in acute and chronic infected skin wounds both to overcome antibiotic resistance and to achieve better wound healing.

Role of Bovine Fetal Platelet-rich Plasma (PRP) on Skin Wound Healing in Mice

2019 ◽  
Vol 16 (1) ◽  
pp. 18-26
Author(s):  
Mardin O. Mohammed ◽  
Osman J. Ali ◽  
Sozan A. Muhamad ◽  
Salam H. Ibrahim ◽  
Goran M. Raouf ◽  
...  
Keyword(s):  
Wound Healing ◽  
Platelet Rich Plasma ◽  
Skin Wound ◽  
Skin Wound Healing

scholarly journals Estrogen promotes cutaneous wound healing via estrogen receptor β independent of its antiinflammatory activities

2010 ◽  
Vol 207 (9) ◽  
pp. 1825-1833 ◽  
Author(s):  
Laura Campbell ◽  
Elaine Emmerson ◽  
Faith Davies ◽  
Stephen C. Gilliver ◽  
Andre Krust ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antiinflammatory Activity ◽  
Hormone Replacement ◽  
Skin Wound ◽  
The Body ◽  
Estrogen Replacement ◽  
Skin Wound Healing ◽  
Skin Repair ◽  
Increased Risk

Post-menopausal women have an increased risk of developing a number of degenerative pathological conditions, linked by the common theme of excessive inflammation. Systemic estrogen replacement (in the form of hormone replacement therapy) is able to accelerate healing of acute cutaneous wounds in elderly females, linked to its potent antiinflammatory activity. However, in contrast to many other age-associated pathologies, the detailed mechanisms through which estrogen modulates skin repair, particularly the cell type–specific role of the two estrogen receptors, ERα and ERβ, has yet to be determined. Here, we use pharmacological activation and genetic deletion to investigate the role of both ERα and ERβ in cutaneous tissue repair. Unexpectedly, we report that exogenous estrogen replacement to ovariectomised mice in the absence of ERβ actually delayed wound healing. Moreover, healing in epidermal-specific ERβ null mice (K14-cre/ERβL2/L2) largely resembled that in global ERβ null mice. Thus, the beneficial effects of estrogen on skin wound healing are mediated by epidermal ERβ, in marked contrast to most other tissues in the body where ERα is predominant. Surprisingly, agonists to both ERα and ERβ are potently antiinflammatory during skin repair, indicating clear uncoupling of inflammation and overall efficiency of repair. Thus, estrogen-mediated antiinflammatory activity is not the principal factor in accelerated wound healing.

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