Study on the role of CD4⁺CD25⁺ regulatory T cells in acute and chronic graft-versus-host disease in murine models

2012 ◽  
Author(s):  
Liang Shao
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Graft Versus Host Disease ◽  
Murine Models ◽  
Host Disease ◽  
Graft Versus Host

The role of regulatory T cells in graft-versus-host disease management

2020 ◽  
Vol 13 (2) ◽  
pp. 141-154 ◽  
Author(s):  
Jennifer S. Whangbo ◽  
Joseph H. Antin ◽  
John Koreth
Keyword(s):  
T Cells ◽  
Disease Management ◽  
Regulatory T Cells ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Role of CD8 Regulatory T Cells versus Tc1 and Tc17 Cells in the Development of Human Graft-versus-Host Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Adriana Gutiérrez-Hoya ◽  
Rubén López-Santiago ◽  
Jorge Vela-Ojeda ◽  
Laura Montiel-Cervantes ◽  
Octavio Rodríguez-Cortés ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Graft Versus Host Disease ◽  
Treg Cells ◽  
Protective Role ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Tc17 Cells

CD8+ T cells that secrete proinflammatory cytokines play a central role in exacerbation of inflammation; however, a new subpopulation of CD8 regulatory T cells has recently been characterized. This study analyzes the prominent role of these different subpopulations in the development of graft-versus-host disease (GVHD). Samples from 8 healthy donors mobilized with Filgrastim® (G-CSF) and 18 patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) were evaluated by flow cytometry. Mobilization induced an increase in Tc1 (p<0.01), Th1 (p<0.001), Tc17 (p<0.05), and CD8+IL-10+ cells (p<0.05), showing that G-CSF induces both pro- and anti-inflammatory profiles. Donor-patient correlation revealed a trend (p=0.06) toward the development of GVHD in patients who receive a high percentage of Tc1 cells. Patients with acute GVHD (aGVHD), either active or controlled, and patients without GVHD were evaluated; patients with active aGVHD had a higher percentage of Tc1 (p<0.01) and Tc17 (p<0.05) cells, as opposed to patients without GVHD in whom a higher percentage of CD8 Treg cells (p<0.01) was found. These findings indicate that the increase in Tc1 and Tc17 cells is associated with GVHD development, while regulatory CD8 T cells might have a protective role in this disease. These tests can be used to monitor and control GVHD.

scholarly journals Narrow-Band Ultraviolet B Phototherapy Ameliorates Acute Graft-Versus-Host Disease of the Intestine by Expansion of Regulatory T Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152823 ◽  
Author(s):  
Akari Hashimoto ◽  
Tsutomu Sato ◽  
Satoshi Iyama ◽  
Masahiro Yoshida ◽  
Soushi Ibata ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Graft Versus Host Disease ◽  
Narrow Band ◽  
Ultraviolet B ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft
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