Secondary degeneration after partial optic nerve transection : mechanisms and the neuroprotective effects of lycium barbarum

2012 ◽  
Author(s):  
Hongying Li
Keyword(s):  
Optic Nerve ◽  
Nerve Transection ◽  
Lycium Barbarum ◽  
Neuroprotective Effects ◽  
Secondary Degeneration ◽  
Optic Nerve Transection

scholarly journals Lycium barbarum (Wolfberry) Increases Retinal Ganglion Cell Survival and Affects both Microglia/Macrophage Polarization and Autophagy after Rat Partial Optic Nerve Transection

2019 ◽  
Vol 28 (5) ◽  
pp. 607-618 ◽  
Author(s):  
Hong-Ying Li ◽  
Mi Huang ◽  
Qiu-Yan Luo ◽  
Xi Hong ◽  
Seeram Ramakrishna ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cells ◽  
Macrophage Polarization ◽  
Previous Method ◽  
Retinal Ganglion ◽  
Nerve Transection ◽  
Lycium Barbarum ◽  
Secondary Degeneration ◽  
Optic Nerves ◽  
Optic Nerve Transection

The rat partial optic nerve transection (PONT) model has been used for studying secondary degeneration of retinal ganglion cells (RGCs) in recent years. In this study, we carried out PONT of the temporal side of rat optic nerves, whereas PONT was carried out of the superior side in the previous publication. We found that this surgery is better and easier than the previous method and can produce a repeatable and reliable model. We detected significant changes in the polarization of microglia/macrophages and the level of autophagy in optic nerves after PONT. We also used this model to detect the effects of the polysaccharides extracted from Lycium barbarum (LBP) on the survival of RGCs and the changes in the polarization of microglia/macrophages and the level of autophagy after PONT. We find that LBP can delay secondary degeneration of RGCs after temporal injury of optic nerves, promote the M2 polarization of microglia/macrophages, and down-regulate the level of autophagy after PONT. In conclusion, we find that the polarization of microglia/macrophages and the autophagy level change after PONT; LBP treatment delays secondary degeneration of RGCs; and the polarization of microglia/macrophages and the level of autophagy are also altered after LBP treatment.

scholarly journals Comparing modes of delivery of a combination of ion channel inhibitors for limiting secondary degeneration following partial optic nerve transection

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Lillian M. Toomey ◽  
Carole A. Bartlett ◽  
Nikolas Gavriel ◽  
Terence McGonigle ◽  
Maimuna Majimbi ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ion Channel ◽  
Local Delivery ◽  
Nerve Transection ◽  
Secondary Degeneration ◽  
Injury Site ◽  
Myelin Structure ◽  
Ion Channel Inhibitors ◽  
Optic Nerve Transection ◽  
Inhibitor Combination

Abstract Injury to the central nervous system is exacerbated by secondary degeneration. Previous research has shown that a combination of orally and locally administered ion channel inhibitors following partial optic nerve injury protects the myelin sheath and preserves function in the ventral optic nerve, vulnerable to secondary degeneration. However, local administration is often not clinically appropriate. This study aimed to compare the efficacy of systemic and local delivery of the ion channel inhibitor combination of lomerizine, brilliant blue G (BBG) and YM872, which inhibits voltage-gated calcium channels, P2X7 receptors and Ca2+ permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors respectively. Following a partial optic nerve transection, adult female PVG rats were treated with BBG and YM872 delivered via osmotic mini pump directly to the injury site, or via intraperitoneal injection, both alongside oral administration of lomerizine. Myelin structure was preserved with both delivery modes of the ion channel inhibitor combination. However, there was no effect of treatment on inflammation, either peripherally or at the injury site, or on the density of oligodendroglial cells. Taken together, the data indicate that even at lower concentrations, the combinatorial treatment may be preserving myelin structure, and that systemic and local delivery are comparable at improving outcomes following neurotrauma.

scholarly journals Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors

2017 ◽  
Vol 12 (2) ◽  
pp. 307 ◽  
Author(s):  
Melinda Fitzgerald ◽  
NathanaelJ Yates ◽  
MarcusK Giacci ◽  
RyanL O'Hare Doig ◽  
Wissam Chiha ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ion Channel ◽  
Nerve Transection ◽  
Secondary Degeneration ◽  
Delayed Treatment ◽  
Ion Channel Inhibitors ◽  
Optic Nerve Transection

scholarly journals Mechanisms of secondary degeneration after partial optic nerve transection

2014 ◽  
Vol 9 (6) ◽  
pp. 565 ◽  
Author(s):  
Kwok-Fai So ◽  
Qi Cui ◽  
Hong-Ying Li ◽  
Yi-Wen Ruan ◽  
Chao-Ran Ren
Keyword(s):  
Optic Nerve ◽  
Nerve Transection ◽  
Secondary Degeneration ◽  
Optic Nerve Transection

scholarly journals Comparison of ion channel inhibitor combinations for limiting secondary degeneration following partial optic nerve transection

2018 ◽  
Vol 237 (1) ◽  
pp. 161-171 ◽  
Author(s):  
Lillian M. Toomey ◽  
Carole A. Bartlett ◽  
Maimuna Majimbi ◽  
Gopana Gopalasingam ◽  
Jennifer Rodger ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ion Channel ◽  
Nerve Transection ◽  
Secondary Degeneration ◽  
Optic Nerve Transection

scholarly journals Effect of Lycium Barbarum (Wolfberry) Polysaccharides on Preserving Retinal Function after Partial Optic Nerve Transection

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e81339 ◽  
Author(s):  
Patrick H. W. Chu ◽  
Hong-Ying Li ◽  
Man-Pan Chin ◽  
Kwok-fai So ◽  
Henry H. L. Chan
Keyword(s):  
Optic Nerve ◽  
Retinal Function ◽  
Nerve Transection ◽  
Lycium Barbarum ◽  
Optic Nerve Transection

Early Events of Secondary Degeneration after Partial Optic Nerve Transection: An Immunohistochemical Study

2010 ◽  
Vol 27 (2) ◽  
pp. 439-452 ◽  
Author(s):  
Melinda Fitzgerald ◽  
Carole A. Bartlett ◽  
Alan R. Harvey ◽  
Sarah A. Dunlop
Keyword(s):  
Optic Nerve ◽  
Immunohistochemical Study ◽  
Nerve Transection ◽  
Secondary Degeneration ◽  
Optic Nerve Transection

scholarly journals Effect of Lycium barbarum (Wolfberry) on Alleviating Axonal Degeneration after Partial Optic Nerve Transection

2015 ◽  
Vol 24 (3) ◽  
pp. 403-417 ◽  
Author(s):  
Hong-Ying Li ◽  
Yi-Wen Ruan ◽  
Phillis Wan-Foon Kau ◽  
Kin Chiu ◽  
Raymond Chuen-Chung Chang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Axonal Degeneration ◽  
Nerve Transection ◽  
Lycium Barbarum ◽  
Optic Nerve Transection
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