Genetic risk factors for late-onset Alzheimer's disease in Chinese

2012 ◽  
Author(s):  
Lu-hua Chen
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Risk ◽  
Late Onset ◽  
Genetic Risk Factors

P3-006: Late-onset Alzheimer's disease genetic risk factors in two Canadian cohorts: CSHA and ACCORD

2013 ◽  
Vol 9 ◽  
pp. P551-P552
Author(s):  
Ardeshir Omoumi ◽  
Alice Fok ◽  
Talitha Greenwood ◽  
Dessa Sadovnick ◽  
Howard Feldman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Risk ◽  
Late Onset ◽  
Genetic Risk Factors

S2-01-04 Progress toward the identification of novel genetic risk factors for late onset Alzheimer's disease

2004 ◽  
Vol 25 ◽  
pp. S25-S26
Author(s):  
Alison M. Goate ◽  
Petra Nowotny ◽  
Tony Hinrichs ◽  
Scott Smemo ◽  
Keoni Kawe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Risk ◽  
Late Onset ◽  
Genetic Risk Factors

Screening of Early and Late Onset Alzheimer’s Disease Genetic Risk Factors in a Cohort of Dementia Patients from Liguria, Italy

2015 ◽  
Vol 12 (8) ◽  
pp. 802-812 ◽  
Author(s):  
Raffaele Ferrari ◽  
Michela Ferrara ◽  
Anwar Alinani ◽  
Roger Sutton ◽  
Francesco Famà ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Risk ◽  
Late Onset ◽  
Genetic Risk Factors ◽  
Dementia Patients

P4-107: Genetic risk factors for posterior cortical atrophy may be distinct from late-onset Alzheimer's disease

2012 ◽  
Vol 8 (4S_Part_18) ◽  
pp. P669-P670 ◽  
Author(s):  
Jonathan Schott ◽  
Sebastian Crutch ◽  
James Uphill ◽  
Natalie Ryan ◽  
Tim Shakespeare ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Risk ◽  
Late Onset ◽  
Genetic Risk Factors ◽  
Cortical Atrophy ◽  
Posterior Cortical Atrophy

scholarly journals APOEe4.Trem2*R47H Mice Show Changes in Alzheimer’s Disease-Relevant Processes in the Absence of Amyloid Plaques

2021 ◽  
Author(s):  
Kevin P. Kotredes ◽  
Adrian Oblak ◽  
Ravi S. Pandey ◽  
Peter Bor-Chian Lin ◽  
Dylan Garceau ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Genetic Risk ◽  
Late Onset ◽  
Model Organism ◽  
Amyloid Plaque ◽  
Genetic Risk Factors ◽  
Mouse Strains

Abstract Late-onset Alzheimer’s disease (LOAD) is the most common human neurodegenerative disease. Legacy amyloidogenic mouse models have been useful for understanding disease progression, however in the face of failing human trials more focus on disease translation with new mouse strains that better model human Alzheimer’s disease (AD) is required. MODEL-AD (Model Organism Development and Evaluation for Late-onset AD) groups are identifying and integrating disease-relevant, humanized gene sequences from public databases to create more translatable mouse models for therapy development. Mice expressing strong genetic risk factors for LOAD, APOEe4 and Trem2*R47H, were extensively aged and assayed using a multi-disciplined phenotyping approach associated with and relative to human AD pathology. Behavioral, transcriptomic, metabolic, and neuropathological assays identified sex and age as the main sources of variation between genotypes including age-specific enrichment of AD-related processes in the absence of mouse amyloid plaque formation. These data provide an important, baseline understanding of the individual effects and interaction between two strong genetic risk factors for LOAD. These two alleles together form a sensitized, background strain (B6.APOE4.Trem2*R47H, which we have termed ‘LOAD1’) necessary to examine how important underlying risk factors interact with any subsequent genetic or environmental cues to drive pathology.

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