Protective effects of natural polyphenols in reactive carbonyl species/lipid peroxidation-induced toxicity

2011 ◽  
Author(s):  
Qin Zhu
Keyword(s):  
Lipid Peroxidation ◽  
Protective Effects ◽  
Natural Polyphenols ◽  
Reactive Carbonyl Species ◽  
Carbonyl Species ◽  
Reactive Carbonyl

scholarly journals Lipid peroxidation derived reactive carbonyl species in free and conjugated forms as an index of lipid peroxidation: limits and perspectives

Redox Biology ◽  
2021 ◽  
pp. 101899
Author(s):  
Alessandra Altomare ◽  
Giovanna Baron ◽  
Erica Gianazza ◽  
Cristina Banfi ◽  
Marina Carini ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Reactive Carbonyl Species ◽  
Carbonyl Species ◽  
Reactive Carbonyl

scholarly journals Reactive Carbonyl Species as Potential Pro-Oxidant Factors Involved in Lichen Planus Pathogenesis

Metabolites ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 213 ◽  
Author(s):  
Mitran ◽  
Nicolae ◽  
Tampa ◽  
Mitran ◽  
Caruntu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Lichen Planus ◽  
Biological Effects ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
The Body ◽  
Control Group ◽  
Reactive Carbonyl Species ◽  
Carbonyl Species ◽  
Reactive Carbonyl

The constant generation of reactive carbonyl species (RCSs) by lipid peroxidation during aerobic metabolism denotes their involvement in cell homeostasis. Skin represents the largest organ of the body that is exposed to lipid peroxidation. Previous studies have suggested the involvement of oxidative stress in the development of lichen planus (LP), a chronic inflammatory skin condition with a complex pathogenesis. The aim of our study is to investigate a panel of pro-oxidants (4-hydroxy-nonenal (4-HNE), thiobarbituric acid reactive substances (TBARS), and malondialdehyde (MDA)), the total antioxidant status (TAS), and thiol-disulfide homeostasis parameters (TDHP), including total thiol (TT), native thiol (NT), disulfides (DS), DS/NT ratio, DS/TT ratio, and NT/TT ratio. The comparative determinations of serum levels of 4-HNE, TBARS, and MDA in patients with LP (n = 31) and controls (n = 26) show significant differences between the two groups (4-HNE: 7.81 ± 1.96 µg/mL vs. 6.15 ± 1.17 µg/mL, p < 0.05, TBARS: 4.23 ± 0.59 µmol/L vs. 1.99 ± 0.23 µmol/L, p < 0.05, MDA: 32.3 ± 6.26 ng/mL vs. 21.26 ± 2.36 ng/mL). The serum levels of TAS are lower in LP patients compared to the control group (269.83 ± 42.63 µmol/L vs. 316.46 ± 28.76 µmol/L, p < 0.05). The serum levels of TDHP are altered in LP patients compared to controls (NT: 388.10 ± 11.32 µmol/L vs. 406.85 ± 9.32., TT: 430.23 ± 9.93 µmol/L vs. 445.88 ± 9.01 µmol/L, DS: 21.06 ± 1.76 µmol/L vs. 19.52 ± 0.77µmol/L). Furthermore, a negative association between pro-oxidants and TAS is identified (4-HNE – rho = −0.83, p < 0.01, TBARS – rho = −0.63, p < 0.01, and MDA – rho = −0.69, p < 0.01). Understanding the mechanisms by which bioactive aldehydes exert their biological effects on the skin could help define effective therapeutical strategies to counteract the cytotoxic effects of these reactive metabolic intermediates.

scholarly journals Detoxification of Reactive Carbonyl Species by Glutathione Transferase Tau Isozymes

2019 ◽  
Vol 10 ◽  
Author(s):  
Jun’ichi Mano ◽  
Sayaka Kanameda ◽  
Rika Kuramitsu ◽  
Nagisa Matsuura ◽  
Yasuo Yamauchi
Keyword(s):  
Glutathione Transferase ◽  
Reactive Carbonyl Species ◽  
Carbonyl Species ◽  
Reactive Carbonyl

scholarly journals Reactive Carbonyl Species and Protein Adducts: Identification Strategies, Biological Mechanisms and Molecular Approaches for Their Detoxification

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 690
Author(s):  
Giancarlo Aldini ◽  
Alessandra A. Altomare
Keyword(s):  
Protein Adducts ◽  
Special Issue ◽  
Biological Mechanisms ◽  
Research Papers ◽  
Molecular Approaches ◽  
Reactive Carbonyl Species ◽  
Carbonyl Species ◽  
Reactive Carbonyl

The Special issue is composed of 13 contributions: 9 research papers and 4 reviews [...]

scholarly journals Targeting Reactive Carbonyl Species with Natural Sequestering Agents

Molecules ◽  
2016 ◽  
Vol 21 (3) ◽  
pp. 280 ◽  
Author(s):  
Sung Hwang ◽  
Yoon-Mi Lee ◽  
Giancarlo Aldini ◽  
Kyung-Jin Yeum
Keyword(s):  
Reactive Carbonyl Species ◽  
Carbonyl Species ◽  
Reactive Carbonyl
Sign in / Sign up

Export Citation Format

Share Document