B lymphocyte development and function in leptin receptor-deficient mice

2005 ◽  
Author(s):  
Jialin Xu
Keyword(s):  
Leptin Receptor ◽  
B Lymphocyte ◽  
Lymphocyte Development ◽  
B Lymphocyte Development ◽  
And Function ◽  
Deficient Mice

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

Cell ◽  
1993 ◽  
Vol 74 (1) ◽  
pp. 143-156 ◽  
Author(s):  
Kenji Kishihara ◽  
Josef Penninger ◽  
Valerie A. Wallace ◽  
Thomas M. Kündig ◽  
Kazuhiro Kawal ◽  
...  
Keyword(s):  
T Cell ◽  
Protein Tyrosine Phosphatase ◽  
B Lymphocyte ◽  
Tyrosine Phosphatase ◽  
Cell Maturation ◽  
Lymphocyte Development ◽  
Protein Tyrosine ◽  
B Lymphocyte Development ◽  
T Cell Maturation ◽  
Deficient Mice

scholarly journals Disrupted B-lymphocyte development and survival in interleukin-2-deficient mice

Immunology ◽  
2001 ◽  
Vol 104 (2) ◽  
pp. 127-134 ◽  
Author(s):  
Michael Schultz ◽  
Stephen H. Clarke ◽  
Larry W. Arnold ◽  
R. Balfour Sartor ◽  
Susan L. Tonkonogy
Keyword(s):  
B Lymphocyte ◽  
Interleukin 2 ◽  
Lymphocyte Development ◽  
B Lymphocyte Development ◽  
Deficient Mice

Loss of IRF-4 Exacerbates the CML-Like Phenotype of IRF-8 Knockout Mice.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 2952-2952
Author(s):  
Jonathan Schatz ◽  
Ruibao Ren ◽  
Harinder Singh
Keyword(s):  
B Lymphocyte ◽  
Myeloid Cells ◽  
Lymphoid Cells ◽  
Myeloproliferative Disease ◽  
Double Knockout ◽  
Large Numbers ◽  
Architectural Features ◽  
B Lymphocyte Development ◽  
And Function ◽  
Deficient Mice

Abstract IRF-4 and IRF-8 are related interferon regulatory factors that are required for the development and function of myeloid and lymphoid cells. Mice deficient in IRF-8 develop a myeloproliferative disorder with many similarities to human chronic myeloid leukemia (CML). Our group has shown that in B-lymphocyte development, IRF-4 and 8 function redundantly to control the pre-B to B transition. Though expression of IRF-4 has been demonstrated in myeloid cells, its role in these lineages has not been defined. We hypothesized that, similar to their role in B-cells, IRF-4 and 8 may to some extent function redundantly in myeloid cells. To test this hypothesis, myelopoiesis was analyzed in IRF-4/8 double knockout (DKO) mice. We found that from seven weeks of age, the DKO animals have a more aggressive leukemic phenotype than the IRF-8 KO mice. The white blood cell (WBC) counts of DKO animals were typically in the range of 40,000 to 80,000 cells per microliter, campared to 15,000 to 20,000 for age-matched IRF-8 KO animals. FACS analysis showed that the increased WBCs in the DKO animals was due to a massive expansion of mature granulcytes. The absolute granulocyte counts of DKO animals were typically 7-fold to 10-fold higher than those of IRF-8 KO animals. In addition, histologic preparations showed that by 15 weeks of age the spleens, lymph nodes, and bone marrow of DKO animals were invaded by large numbers of mature granulocytes and pseudo-Gaucher cells, with complete effacement of the normal micro-architecture. Age-matched IRF-8 KO animals showed invasion to a lesser degree, with preservation of many of the normal architectural features. In conclusion, IRF-4 is an important myeloid tumor suppressor, whose loss augments the myeloproliferative disease manifested in IRF-8 deficient mice. This suggests the two transcription factors, similar to their role in B-cell development, function redundantly to control the normal maturation of myeloid-lineage cells.

Bone Marrow B Lymphocyte Development in c-abl-Deficient Mice

1995 ◽  
Vol 165 (1) ◽  
pp. 44-54 ◽  
Author(s):  
Jeff D. Hardin ◽  
Sharon Boast ◽  
Pamela L. Schwartzberg ◽  
Grace Lee ◽  
Fred W. Alt ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Lymphocyte ◽  
Lymphocyte Development ◽  
B Lymphocyte Development ◽  
Deficient Mice

scholarly journals Partial block in B lymphocyte development at the transition into the pre-B cell receptor stage in Vpre-B1-deficient mice

1999 ◽  
Vol 11 (3) ◽  
pp. 453-460 ◽  
Author(s):  
Annica Mårtensson ◽  
Yair Argon ◽  
Fritz Melchers ◽  
Jeanne L. Duland ◽  
Inga-Lill Mårtensson
Keyword(s):  
B Cell ◽  
B Lymphocyte ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Lymphocyte Development ◽  
B Lymphocyte Development ◽  
Deficient Mice

THU0183 Treatment with Tofacitinib Inhibits Human Naïve B Lymphocyte Development and Function In Vitro

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 251.2-251
Author(s):  
J. Thiel ◽  
K. Fischer ◽  
R.E. Voll ◽  
R. Lorenzetti ◽  
B. Bannert ◽  
...  
Keyword(s):  
B Lymphocyte ◽  
Lymphocyte Development ◽  
B Lymphocyte Development ◽  
And Function

scholarly journals Loss of the FOXP1 Transcription Factor Leads to Deregulation of B Lymphocyte Development and Function at Multiple Stages

2019 ◽  
Vol 3 (10) ◽  
pp. 447-462 ◽  
Author(s):  
Joseph D. Dekker ◽  
Gisele V. Baracho ◽  
Zilu Zhu ◽  
Gregory C. Ippolito ◽  
Robert J. Schmitz ◽  
...  
Keyword(s):  
Transcription Factor ◽  
B Lymphocyte ◽  
Lymphocyte Development ◽  
B Lymphocyte Development ◽  
And Function ◽  
Multiple Stages
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