Investigating beta-amyloid peptide neurotoxicity from neuronal apoptosis to endoplasmic reticulum collapse : translational research back to basic science research

2009 ◽  
Author(s):  
Sau-wan Lai
Keyword(s):  
Endoplasmic Reticulum ◽  
Translational Research ◽  
Basic Science ◽  
Neuronal Apoptosis ◽  
Science Research ◽  
Beta Amyloid ◽  
Amyloid Peptide ◽  
Beta Amyloid Peptide ◽  
Basic Science Research

scholarly journals Reduction of calcium release from the endoplasmic reticulum could only provide partial neuroprotection against beta-amyloid peptide toxicity

2003 ◽  
Vol 87 (6) ◽  
pp. 1413-1426 ◽  
Author(s):  
Ka-Chun Suen ◽  
Kim-Fung Lin ◽  
Wassim Elyaman ◽  
Kwok-Fai So ◽  
Raymond Chuen-Chung Chang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Calcium Release ◽  
Beta Amyloid ◽  
Amyloid Peptide ◽  
Beta Amyloid Peptide

scholarly journals Reduction of calcium release from the endoplasmic reticulum could only provide partial neuroprotection against beta-amyloid peptide toxicity

2004 ◽  
Vol 88 (4) ◽  
pp. 1040-1040
Author(s):  
Ka-Chun Suen ◽  
Kim-Fung Lin ◽  
Wassim Elyaman ◽  
Kwok-Fai So ◽  
Raymond Chuen-Chung Chang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Calcium Release ◽  
Beta Amyloid ◽  
Amyloid Peptide ◽  
Beta Amyloid Peptide

scholarly journals A successful story of translational orthodontic research: Micro-osteoperforation-from experiments to clinical practice

2017 ◽  
Vol 7 ◽  
pp. 6-11 ◽  
Author(s):  
Michelle Yuching Chou ◽  
Mani Alikhani
Keyword(s):  
Clinical Practice ◽  
Translational Research ◽  
Clinical Application ◽  
Clinical Studies ◽  
Basic Science ◽  
Scientific Evidence ◽  
Science Research ◽  
Daily Practice ◽  
Research Projects ◽  
Basic Science Research

The gap between basic science research and clinical application has long existed and therefore translational research has emerged in recent years to bridge such gap. Consortium for Translational Orthodontic Research (CTOR) was established with missions to integrate resources from different entities and to provide a platform for interdisciplinary groups who share the same vision to exchange ideas and inspire innovations. During its short existence, CTOR has successfully carried out several research projects which led to various innovations. Micro-osteoperforation is by far one of the most successful examples of translational research in the orthodontic field. It exemplifies how translational research can benefit scientists, clinicians, and patients. In this article, the process of its development, the rationale and scientific evidence from animal and clinical studies, and how it can be applied in daily practice will be depicted.

scholarly journals Translational Science Research: Towards Better Health

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Emir Festic ◽  
Ognjen Gajic
Keyword(s):  
Clinical Research ◽  
Translational Research ◽  
Bosnia And Herzegovina ◽  
21St Century ◽  
Basic Science ◽  
Translational Medicine ◽  
Science Research ◽  
Research Centers ◽  
Research Knowledge ◽  
Basic Science Research

Even though it is considered a 21st century term, translational research has been present for much longer. Idea of translating experimental discovery to its’ clinical application and use is old as research itself. However, it is the understanding of missing links between the basic science research and clinical research that emerged in the past decade and mobilized scientific and clinical communities and organizations worldwide. Hence term, translational research, which represents an “enterprise of harnessing knowledge from basic sciences to produce new drugs, devices, and treatment options for patients” (1). It has been also characterized as “effective translation of the new knowledge, mechanisms, and techniques generated by advances in basic science research into new approaches for prevention, diagnosis, and treatment of disease, which is essential for improving health” (2).This translation is a complex process and involves more than one step for transfer of research knowledge. At least 3 such roadblocks have been identified (Figure 1) ; T1 translation: “The transfer of new understandings of disease mechanisms gained in the laboratory into the development of new methods for diagnosis, therapy, and prevention and their first testing in humans”, T2 translation: “The translation of results from clinical studies into everyday clinical practice and health decision making”, and T3 translation: “Practice-based research, which is often necessary before distilled knowledge (e.g., systematic reviews, guidelines) can be implemented in practice” (3-5).The international research community rapidly recognized importance for promotion of translational research and made it their priority(5). In the USA, National Institutes of Health, (NIH) expects to fund 60 translational research centers with a budget of $500 million per year by 2012 (6). Besides academic centers, foundations, industry, disease-related organizations, and individual hospitals and health systems have also established translational research programs and at least 2 journals (Translational Medicine and the Journal of Translational Medicine) are devoted to the topic. In Europe, translational research has become a centerpiece of the European Commission’s €6 billion budget for health related research, and the United Kingdom has invested £450 million over 5 years to establish translational research centers (7).In this issue of Bosnian Journal of Basic Medical Sciences, members of medical section of Bosnian and Herzegovinian-American Academy of Arts and Sciences (BHAAAS), contributed their own work and expertise to bridge the gap between basic and clinical research, between inventing the treatments and getting them used in practice, and laid down foundations for future collaborative development of translational research in Bosnia and Herzegovina, as well as in the region (8).At the first glance of this issue’s table of content, a reader will easily notice the variety and breadth of topics and themes, from medical informatics and genetics, to hematology and oncology, pulmonary and critical care medicine, orthopedics, trauma surgery and neurosurgery. However, all of the articles share common ideas of translation of knowledge, from bench to bedside and back, and individualized approach to medicine, which are the true hallmarks of the 21st century medicine.Deeper under the surface and titles, there lies our common privilege and honor to be part of a broader mission of BHAAAS: to connect with our fellow physicians and scientists, and to build bridges of cooperation with our homeland, to promote the spirit of intellectual diversity and free exchange of ideas with the strong belief that this knowledge sharing will promote betterment of health in Bosnia and Herzegovina

P1-429: Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease-associated beta-amyloid peptide

2008 ◽  
Vol 4 ◽  
pp. T345-T345
Author(s):  
Cláudia M.F. Pereira ◽  
Elisabete B. Ferreiro ◽  
Rui O. Costa ◽  
Rosa M.M.B. Resende ◽  
Sandra M. Cardoso ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Endoplasmic Reticulum ◽  
Cross Talk ◽  
Beta Amyloid ◽  
Amyloid Peptide ◽  
Beta Amyloid Peptide

scholarly journals O2-09-02: Endoplasmic reticulum plays important roles in initiating autophagy in cultured hippocampal neurons after exposure to beta-amyloid peptide

2012 ◽  
Vol 8 (4S_Part_7) ◽  
pp. P252-P253
Author(s):  
Raymond Chuen-Chung Chang ◽  
Natalie Qishan Zhang ◽  
Clara Hung ◽  
Suthicha Wuwongse ◽  
Yuen-shan Ho
Keyword(s):  
Endoplasmic Reticulum ◽  
Hippocampal Neurons ◽  
Beta Amyloid ◽  
Amyloid Peptide ◽  
Beta Amyloid Peptide ◽  
Cultured Hippocampal Neurons

A Perspective On The Impact of COVID-19 Pandemic in Basic Science Research and its Future implications

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Yam Nath Paudel ◽  
Efthalia Angelopoulou ◽  
Bhupendra Raj Giri ◽  
Christina Piperi ◽  
Iekhsan Othman ◽  
...  
Keyword(s):  
Basic Science ◽  
Large Scale ◽  
Preventive Measure ◽  
Science Research ◽  
Research Institutes ◽  
Basic Science Research ◽  
Long Term Consequences ◽  
Long Term Impact ◽  
The Impact

: COVID-19 has emerged as a devastating pandemic of the century that the current generations have ever experienced. The COVID-19 pandemic has infected more than 12 million people around the globe and 0.5 million people have succumbed to death. Due to the lack of effective vaccines against the COVID-19, several nations throughout the globe has imposed a lock-down as a preventive measure to lower the spread of COVID-19 infection. As a result of lock-down most of the universities and research institutes has witnessed a long pause in basic science research ever. Much has been talked about the long-term impact of COVID-19 in economy, tourism, public health, small and large-scale business of several kind. However, the long-term implication of these research lab shutdown and its impact in the basic science research has not been much focused. Herein, we provide a perspective that portrays a common problem of all the basic science researchers throughout the globe and its long-term consequences.

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