Bone morphogenetic proteins (BMPS) mediate cellular response and regulate neural stem cell differentiation after acute spinal cord injury in the adult mice

2008 ◽  
Author(s):  
Qi Xiao
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Neural Stem Cell ◽  
Bone Morphogenetic Proteins ◽  
Cellular Response ◽  
Stem Cell Differentiation ◽  
Adult Mice ◽  
Cord Injury

scholarly journals Combined Rosiglitazone and Forskolin Have Neuroprotective Effects in SD Rats after Spinal Cord Injury

PPAR Research ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Qing-qi Meng ◽  
Wei Lei ◽  
Hao Chen ◽  
Zhen-cheng Feng ◽  
Li-qiong Hu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Stem Cell Differentiation ◽  
Neuroprotective Effects ◽  
Spinal Cord Neurons ◽  
Inflammatory Cascade ◽  
Sd Rat ◽  
Cord Injury

The peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist rosiglitazone inhibits NF-κB expression and endogenous neural stem cell differentiation into neurons and reduces the inflammatory cascade after spinal cord injury (SCI). The aim of this study was to explore the mechanisms underlying rosiglitazone-mediated neuroprotective effects and regulation of the balance between the inflammatory cascade and generation of endogenous spinal cord neurons by using a spinal cord-derived neural stem cell culture system as well as SD rat SCI model. Activation of PPAR-γ could promote neural stem cell proliferation and inhibit PKA expression and neuronal formation in vitro. In the SD rat SCI model, the rosiglitazone + forskolin group showed better locomotor recovery compared to the rosiglitazone and forskolin groups. MAP2 expression was higher in the rosiglitazone + forskolin group than in the rosiglitazone group, NF-κB expression was lower in the rosiglitazone + forskolin group than in the forskolin group, and NeuN expression was higher in the rosiglitazone + forskolin group than in the forskolin group. PPAR-γ activation likely inhibits NF-κB, thereby reducing the inflammatory cascade, and PKA activation likely promotes neuronal cell regeneration.

Pentapeptide IKVAV-engineered hydrogels for neural stem cell attachment

2021 ◽  
Author(s):  
Yixia Yin ◽  
Wenwu Wang ◽  
Qi Shao ◽  
Binbin Li ◽  
Dan Yu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Attachment ◽  
Injury Repair ◽  
Cord Injury ◽  
Proliferation Ability

A IKVAV-functionalized hydrogel is developed. It not only enhances neural stem cell (NSC) attachment, growth, and differentiation, but also maintains the proliferation ability of the NSC spheroids in the hydrogel for spinal cord injury repair.

scholarly journals A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury

2018 ◽  
Vol 22 (6) ◽  
pp. 941-950.e6 ◽  
Author(s):  
Erik Curtis ◽  
Joel R. Martin ◽  
Brandon Gabel ◽  
Nikki Sidhu ◽  
Teresa K. Rzesiewicz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Phase I ◽  
Cell Transplantation ◽  
Neural Stem Cell ◽  
Phase I Study ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

Pain with no gain: Allodynia following neural stem cell transplantation in spinal cord injury

2006 ◽  
Vol 201 (2) ◽  
pp. 335-348 ◽  
Author(s):  
M MACIAS ◽  
M SYRING ◽  
M PIZZI ◽  
M CROWE ◽  
A ALEXANIAN ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Neural Stem Cell ◽  
Cord Injury
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