Characterization of the functional role of AMP-activated protein kinase in tumor suppression

2007 ◽  
Author(s):  
Heong-fai, Michael Liu
Keyword(s):  
Protein Kinase ◽  
Tumor Suppression ◽  
Functional Role ◽  
Amp Activated Protein Kinase

scholarly journals Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells

2002 ◽  
Vol 363 (1) ◽  
pp. 167 ◽  
Author(s):  
Lee G. D. FRYER ◽  
Fabienne FOUFELLE ◽  
Kay BARNES ◽  
Stephen A. BALDWIN ◽  
Angela WOODS ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Glucose Transport ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Amp Activated Protein Kinase ◽  
Stimulation Of

scholarly journals Functional role of AMP-activated protein kinase in the heart during exercise

FEBS Letters ◽  
2005 ◽  
Vol 579 (10) ◽  
pp. 2045-2050 ◽  
Author(s):  
Nicolas Musi ◽  
Michael F. Hirshman ◽  
Michael Arad ◽  
Yanqiu Xing ◽  
Nobuharu Fujii ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Functional Role ◽  
Amp Activated Protein Kinase

Structural and Thermodynamic Characterization of theEscherichia coliRelBE Toxin−Antitoxin System:  Indication for a Functional Role of Differential Stability†

Biochemistry ◽  
2007 ◽  
Vol 46 (43) ◽  
pp. 12152-12163 ◽  
Author(s):  
Izhack Cherny ◽  
Martin Overgaard ◽  
Jonas Borch ◽  
Yaron Bram ◽  
Kenn Gerdes ◽  
...  
Keyword(s):  
Functional Role ◽  
Thermodynamic Characterization ◽  
Differential Stability

scholarly journals The role of AMP-activated protein kinase in quercetin-induced apoptosis of HL-60 cells

2014 ◽  
Vol 46 (5) ◽  
pp. 394-400 ◽  
Author(s):  
J. Xiao ◽  
G. Niu ◽  
S. Yin ◽  
S. Xie ◽  
Y. Li ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Induced Apoptosis ◽  
Amp Activated Protein Kinase

Role of the AMP-activated protein kinase in regulating fatty acid metabolism during exerciseThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

2009 ◽  
Vol 34 (3) ◽  
pp. 315-322 ◽  
Author(s):  
Gregory R. Steinberg
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Protein Kinase ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Moderate Intensity ◽  
Amp Activated Protein Kinase

During moderate-intensity exercise, fatty acids are the predominant substrate for working skeletal muscle. The release of fatty acids from adipose tissue stores, combined with the ability of skeletal muscle to actively fine tune the gradient between fatty acid and carbohydrate metabolism, depending on substrate availability and energetic demands, requires a coordinated system of metabolic control. Over the past decade, since the discovery that AMP-activated protein kinase (AMPK) was increased in accordance with exercise intensity, there has been significant interest in the proposed role of this ancient stress-sensing kinase as a critical integrative switch controlling metabolic responses during exercise. In this review, studies examining the role of AMPK as a regulator of fatty acid metabolism in both adipose tissue and skeletal muscle during exercise will be discussed. Exercise induces activation of AMPK in adipocytes and regulates triglyceride hydrolysis and esterfication through phosphorylation of hormone sensitive lipase (HSL) and glycerol-3-phosphate acyl-transferase, respectively. In skeletal muscle, exercise-induced activation of AMPK is associated with increases in fatty acid uptake, phosphorylation of HSL, and increased fatty acid oxidation, which is thought to occur via the acetyl-CoA carboxylase-malony-CoA-CPT-1 signalling axis. Despite the importance of AMPK in regulating fatty acid metabolism under resting conditions, recent evidence from transgenic models of AMPK deficiency suggest that alternative signalling pathways may also be important for the control of fatty acid metabolism during exercise.

scholarly journals Functional Role of Protein Kinase B/Akt in Gastric Acid Secretion

2001 ◽  
Vol 276 (49) ◽  
pp. 46436-46444 ◽  
Author(s):  
Andrea Todisco ◽  
Nonthalee Pausawasdi ◽  
Saravanan Ramamoorthy ◽  
John Del Valle ◽  
Rebecca W. Van Dyke ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Functional Role ◽  
Protein Kinase B

The emerging role of AMP-activated protein kinase in cholestatic liver diseases

2017 ◽  
Vol 125 ◽  
pp. 105-113 ◽  
Author(s):  
Xiaojiaoyang Li ◽  
Runping Liu ◽  
Luyong Zhang ◽  
Zhenzhou Jiang
Keyword(s):  
Protein Kinase ◽  
Liver Diseases ◽  
Amp Activated Protein Kinase

scholarly journals Beneficial Role of Erythrocyte Adenosine A2B Receptor–Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia

Circulation ◽  
2016 ◽  
Vol 134 (5) ◽  
pp. 405-421 ◽  
Author(s):  
Hong Liu ◽  
Yujin Zhang ◽  
Hongyu Wu ◽  
Angelo D’Alessandro ◽  
Gennady G. Yegutkin ◽  
...  
Keyword(s):  
Protein Kinase ◽  
High Altitude ◽  
Altitude Hypoxia ◽  
Kinase Activation ◽  
Beneficial Role ◽  
Protein Kinase Activation ◽  
A2b Receptor ◽  
Amp Activated Protein Kinase ◽  
Adenosine A2b
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