Modulation of vascular function by genistein through cAMP-PKA signaling cascade in porcine coronary artery

2006 ◽  
Author(s):  
Wai-hung, William Ng
Keyword(s):  
Coronary Artery ◽  
Vascular Function ◽  
Signaling Cascade ◽  
Porcine Coronary Artery

Mechanical Properties of the Porcine Coronary Artery

2009 ◽  
Author(s):  
Chantal N. van den Broek ◽  
Arjen van der Horst ◽  
Marcel C. N. Rutten ◽  
Frans N. van de Vosse
Keyword(s):  
Mechanical Properties ◽  
Coronary Artery ◽  
Vascular Function ◽  
Arterial Wall ◽  
Material Model ◽  
Porcine Coronary Artery ◽  
Balloon Catheters ◽  
General Parameter ◽  
Fiber Reinforced Material ◽  
Parameter Values

Knowledge of the mechanical properties of arteries is important to understand vascular function during disease and the effect of interventions, such as PTCA treatment. A mechanical model of the vascular tree would facilitate the improvement of (balloon-)catheters and stents. The aim of this research is to propose general parameter values for the fiber-reinforced material model as proposed by Driessen et al. (2005) that can describe the arterial wall behavior of the porcine left anterior descending coronary artery (LAD, fig. 1a) at physiological axial stretch.

Mechanical Properties of the Porcine Coronary Artery

2008 ◽  
Author(s):  
Chantal N. van den Broek ◽  
Marcel M. Rutten ◽  
Frans N. van de Vosse
Keyword(s):  
Mechanical Properties ◽  
Coronary Artery ◽  
Mechanical Model ◽  
Vascular Function ◽  
Vascular Tree ◽  
Porcine Coronary Artery ◽  
Balloon Catheters

Knowledge of mechanical properties of living arteries is important to understand vascular function during health, disease and intervention. A mechanical model of the vascular tree would facilitate the development of (balloon-)catheters and stents.

scholarly journals A New Observation on the Stress Distribution in the Coronary Artery Wall

2009 ◽  
Vol 131 (11) ◽  
Author(s):  
Chong Wang ◽  
Xiaomei Guo ◽  
Ghassan S. Kassab
Keyword(s):  
Coronary Artery ◽  
Stress Distribution ◽  
Vascular Function ◽  
Stress Gradient ◽  
Circumferential Stress ◽  
Wall Stress ◽  
Opening Angle ◽  
Porcine Coronary Artery ◽  
Physiological Loading ◽  
Health And Disease

The stress distribution in the vessel wall has an important bearing on vascular function in health and disease. We studied the relationship between the transmural stress distribution and the opening angle (OA) to determine the stress gradient. The simulation of wall stress was based on transmural measurements of strain and material properties of coronary arteries in reference to the zero-stress state. A one-layer model with material constants of the intact vessel was used to calculate the circumferential stress distribution. A sensitivity analysis using both one- and two-layer models (intima-media and adventitia layers) was carried out to study the effect of the OA on the circumferential stress distribution and average circumferential stress. A larger OA always shifts the circumferential stress from the intima-media to the adventitia layer. We report a new observation that the circumferential stress at the adventitia may exceed that at the intima at physiological loading due to the larger OA in the porcine coronary artery. This has important implications for growth and remodeling, where an increase in opening angle may shift excessive stress from the inner layer to the outer layer.

Characterization of Thromboxane A2/Prostaglandin H2 Receptors in Porcine Coronary Artery -The Inhibitory Effect of a Novel Dibenzoxepin Derivative, KW-3635

1992 ◽  
Vol 67 (05) ◽  
pp. 582-584 ◽  
Author(s):  
Ichiro Miki ◽  
Akio Ishii
Keyword(s):  
Coronary Artery ◽  
Binding Sites ◽  
Thromboxane A2 ◽  
Inhibitory Effect ◽  
Scatchard Analysis ◽  
Single Class ◽  
Porcine Coronary Artery ◽  
Equilibrium Binding ◽  
H2 Receptors

SummaryWe characterized the thromboxane A2/prostaglandin H2 receptors in porcine coronary artery. The binding of [3H]SQ 29,548, a thromboxane A2 antagonist, to coronary arterial membranes was saturable and displaceable. Scatchard analysis of equilibrium binding showed a single class of high affinity binding sites with a dissociation constant of 18.5 ±1.0 nM and the maximum binding of 80.7 ± 5.2 fmol/mg protein. [3H]SQ 29,548 binding was concentration-dependently inhibited by thromboxane A2 antagonists such as SQ 29,548, BM13505 and BM13177 or the thromboxane A2 agonists such as U46619 and U44069. KW-3635, a novel dibenzoxepin derivative, concentration-dependently inhibited the [3H]SQ 29,548 binding to thromboxane A2/prosta-glandin H2 receptors in coronary artery with an inhibition constant of 6.0 ± 0.69 nM (mean ± S.E.M.).

Effect of Local Paclitaxel Delivery Following Stenting on Restenosis and Morphology in the Porcine Coronary Artery

2008 ◽  
Vol 2 (1) ◽  
pp. 299-303
Author(s):  
Martin Oberhoff ◽  
Matthias Lerch ◽  
Christian Herdeg ◽  
Axel Kuttner ◽  
Stephen Schroder ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Porcine Coronary Artery

Osteoprotegerin and Osteopontin Serum Levels are Associated with Vascular Function and Inflammation in Coronary Artery Disease Patients

2020 ◽  
Vol 18 (5) ◽  
pp. 523-530 ◽  
Author(s):  
Konstantinos Maniatis ◽  
Gerasimos Siasos ◽  
Evangelos Oikonomou ◽  
Manolis Vavuranakis ◽  
Marina Zaromytidou ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Endothelial Function ◽  
Vascular Function ◽  
Serum Levels ◽  
Atherosclerosis Progression ◽  
Control Subjects ◽  
Significant Difference ◽  
Artery Disease ◽  
Stable Cad

Background: Osteoprotegerin and osteopontin have recently emerged as key factors in both vascular remodelling and atherosclerosis progression. Interleukin-6 (IL-6) is an inflammatory cytokine with a key role in atherosclerosis. The relationship of osteoprotegerin, osteopontin, and IL-6 serum levels with endothelial function and arterial stiffness was evaluated in patients with coronary artery disease (CAD). Methods: We enrolled 219 patients with stable CAD and 112 control subjects. Osteoprotegerin, osteopontin and IL-6 serum levels were measured using an ELISA assay. Endothelial function was evaluated by flow-mediated dilation (FMD) in the brachial artery and carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness. Results: There was no significant difference between control subjects and CAD patients according to age and sex. Compared with control subjects, CAD patients had significantly impaired FMD (p<0.001) and increased PWV (p=0.009). CAD patients also had significantly higher levels of osteoprotegerin (p<0.001), osteopontin (p<0.001) and IL-6 (p=0.03), compared with control subjects. Moreover, IL-6 levels were correlated with osteoprotegerin (r=0.17, p=0.01) and osteopontin (r=0.30, p<0.001) levels. FMD was correlated with osteoprotegerin levels independent of possible confounders [b coefficient= - 0.79, 95% CI (-1.54, -0.05), p=0.04]. Conclusion: CAD patients have increased osteoprotegerin, osteopontin and IL-6 levels. Moreover, there is a consistent association between osteoprotegerin and osteopontin serum levels, vascular function and inflammation in CAD patients. These findings suggest another possible mechanism linking osteoprotegerin and osteopontin serum levels with CAD progression through arterial wall stiffening and inflammation.

scholarly journals Effects of Monotherapy with Clopidogrel vs. Aspirin on Vascular Function and Hemostatic Measurements in Patients with Coronary Artery Disease: The Prospective, Crossover I-LOVE-MONO Trial

2021 ◽  
Vol 10 (12) ◽  
pp. 2720
Author(s):  
Hyun-Woong Park ◽  
Min-Gyu Kang ◽  
Jong-Hwa Ahn ◽  
Jae-Seok Bae ◽  
Udaya S. Tantry ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Endothelial Function ◽  
Vascular Function ◽  
Platelet Reactivity ◽  
Reactive Hyperemia ◽  
Open Label ◽  
Peripheral Arterial Tonometry ◽  
Coagulation Activity ◽  
Artery Disease

To evaluate the effect of clopidogrel vs. aspirin monotherapy on vascular function and hemostatic measurement. Background: Monotherapy with P2Y12 receptor inhibitor vs. aspirin can be a useful alterative to optimize clinical efficacy and safety in high-risk patients with coronary artery disease (CAD). Methods: We performed a randomized, open-label, two-period crossover study in stented patients receiving at least 6-month of dual antiplatelet therapy (DAPT). Thirty CAD patients with moderate-to-high ischemic risk were randomly assigned to receive either 75 mg of clopidogrel or 100 mg of aspirin daily for 4 weeks, and were crossed over to the other strategy for 4 weeks. Vascular function was evaluated with reactive hyperemia-peripheral arterial tonometry (RH-PAT) and brachial-ankle pulse wave velocity (baPWV). Hemostatic profiles were measured with VerifyNow and thromboelastography (TEG). The primary endpoint was the reactive hyperemia index (RHI) during clopidogrel or aspirin monotherapy. Results: Clopidogrel vs. aspirin monotherapy was associated with better endothelial function (RHI: 2.11 ± 0.77% vs. 1.87 ± 0.72%, p = 0.045), lower platelet reactivity (130 ± 64 vs. 214 ± 50 P2Y12 reaction unit [PRU], p < 0.001) and prolonged reaction time (TEG R: 5.5 ± 1.2 vs. 5.1 ± 1.1 min, p = 0.037). In multivariate analysis, normal endothelial function (RHI ≥ 2.1) was significantly associated with clot kinetics (TEG angle ≤ 68 degree) and ‘PRU ≤ 132’. ‘PRU ≤ 132’ was achieved in 46.2% vs. 3.8% during clopidogrel administration vs. aspirin monotherapy (odds ratio 21.4, 95% confidence interval 2.7 to 170.1, p < 0.001). Conclusions: In CAD patients, clopidogrel vs. aspirin monotherapy was associated with better endothelial function, greater platelet inhibition and lower coagulation activity, suggesting pleiotropic effects of clopidogrel on endothelial function and hemostatic profiles.

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