Cell-cell interactions and cell junction dynamics in the mammalian testis

2005 ◽  
Author(s):  
Ching-hang Wong
Keyword(s):  
Cell Interactions ◽  
Cell Junction ◽  
Mammalian Testis ◽  
Cell Cell

scholarly journals Testicular organoids to study cell–cell interactions in the mammalian testis

Andrology ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 835-841 ◽  
Author(s):  
S. Sakib ◽  
T. Goldsmith ◽  
A. Voigt ◽  
I. Dobrinski
Keyword(s):  
Cell Interactions ◽  
Mammalian Testis ◽  
Cell Cell

scholarly journals Detection of Cell-Cell Interactions via Photocatalytic Cell Tagging

2021 ◽  
Author(s):  
Rob C. Oslund ◽  
Tamara Reyes-Robles ◽  
Cory H. White ◽  
Jake H. Tomlinson ◽  
Kelly A. Crotty ◽  
...  
Keyword(s):  
Mononuclear Cells ◽  
Immune Cell ◽  
Cell Interactions ◽  
Cell Junction ◽  
Cellular Interactions ◽  
Single Domain Antibody ◽  
Peripheral Blood Mononuclear ◽  
Immune Synapse ◽  
Spatio Temporal ◽  
Cell Cell

AbstractCell-cell interactions drive essential biological processes critical to cell and tissue development, function, pathology, and disease outcome. The growing appreciation of immune cell interactions within disease environments has led to significant efforts to develop protein- and cell-based therapeutic strategies. A better understanding of these cell-cell interactions will enable the development of effective immunotherapies. However, characterizing these complex cellular interactions at molecular resolution in their native biological contexts remains challenging. To address this, we introduce photocatalytic cell tagging (PhoTag), a modality agnostic platform for profiling cell-cell interactions. Using photoactivatable flavin-based cofactors, we generate phenoxy radical tags for targeted labeling at the cell surface. Through various targeting modalities (e.g. MHC-Multimer, antibody, single domain antibody (VHH)) we deliver a flavin photocatalyst for cell tagging within monoculture, co-culture, and peripheral blood mononuclear cells. PhoTag enables highly selective tagging of the immune synapse between an immune cell and an antigen-presenting cell through targeted labeling at the cell-cell junction. This allowed for the ability to profile gene expression-level differences between interacting and bystander cell populations. Given the modality agnostic and spatio-temporal nature of PhoTag, we envision its broad utilization to detect and profile intercellular interactions within an immune synapse and other confined cellular regions for any biological system.

scholarly journals First person – Anja Schmidt and Long Li

2021 ◽  
Vol 134 (21) ◽  
Keyword(s):  
Early Career ◽  
Cell Interactions ◽  
Cell Junction ◽  
Cortical Region ◽  
First Person ◽  
Capping Proteins ◽  
Early Career Researchers ◽  
Chapel Hill ◽  
Selection Of ◽  
Cell Cell

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Anja Schmidt and Long Li are co-first authors on ‘ Dia- and Rok-dependent enrichment of capping proteins in a cortical region’, published in JCS. Anja conducted the research described in this article while a postdoc in Jörg Großhans's lab at Georg-August-University Göttingen, Germany. She is now a postdoc in the lab of Mark Peifer at Chapel Hill, NC, USA, investigating cell–cell interactions, mechanotransduction and cell–cell junction dynamics. Long is a postdoc in the lab of Jörg Großhans at Philipps-Universität Marburg, Germany, where he focuses on the regulation and interaction between microtubule and actin interaction.

Cell-cell interactions in diabetic neuropathy

2007 ◽  
Vol 2 (S 1) ◽  
Author(s):  
I Lukic ◽  
S Stoyanov ◽  
A Erhardt ◽  
P Nawroth ◽  
A Bierhaus
Keyword(s):  
Diabetic Neuropathy ◽  
Cell Interactions ◽  
Cell Cell
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