The expression of various growth factors in the normal human prostate, benign prostatic hyperplasia, and prostate carcinoma

1996 ◽  
Author(s):  
Maria Lourdes C Herrera
Keyword(s):  
Growth Factors ◽  
Benign Prostatic Hyperplasia ◽  
Prostate Carcinoma ◽  
Prostatic Hyperplasia ◽  
Human Prostate ◽  
Normal Human

Angiotensin AT4 receptors in the normal human prostate and benign prostatic hyperplasia

2001 ◽  
Vol 184 (1-2) ◽  
pp. 187-192 ◽  
Author(s):  
Diem T Dinh ◽  
Albert G Frauman ◽  
David J Casley ◽  
Colin I Johnston ◽  
Maurice E Fabiani
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Human Prostate ◽  
Normal Human

Localization of angiotensin-converting enzyme in the human prostate: pathological expression in benign prostatic hyperplasia

2001 ◽  
Vol 195 (5) ◽  
pp. 571-579 ◽  
Author(s):  
Labrini Nassis ◽  
Albert G. Frauman ◽  
Mitsuru Ohishi ◽  
Jialong Zhuo ◽  
David J. Casley ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Angiotensin Converting Enzyme ◽  
Prostatic Hyperplasia ◽  
Human Prostate ◽  
Converting Enzyme

scholarly journals Antiinflammatory effect of androgen receptor activation in human benign prostatic hyperplasia cells

2012 ◽  
Vol 214 (1) ◽  
pp. 31-43 ◽  
Author(s):  
Linda Vignozzi ◽  
Ilaria Cellai ◽  
Raffaella Santi ◽  
Letizia Lombardelli ◽  
Annamaria Morelli ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Factors ◽  
Androgen Receptor ◽  
Benign Prostatic Hyperplasia ◽  
Stromal Cells ◽  
Receptor Activation ◽  
Prostatic Hyperplasia ◽  
Serum Testosterone Level ◽  
Antiinflammatory Effect ◽  
Inflammatory Growth

Progression of benign prostatic hyperplasia (BPH) involves chronic inflammation and immune dysregulation. Preclinical studies have demonstrated that prostate inflammation and tissue remodeling are exacerbated by hypogonadism and prevented by testosterone supplementation. We now investigated whether, in humans, hypogonadism was associated with more severe BPH inflammation and the in vitro effect of the selective androgen receptor agonist dihydrotestosterone (DHT) on cultures of stromal cells derived from BPH patients (hBPH). Histological analysis of inflammatory infiltrates in prostatectomy specimens from a cohort of BPH patients and correlation with serum testosterone level was performed. Even after adjusting for confounding factors, hypogonadism was associated with a fivefold increased risk of intraprostatic inflammation, which was also more severe than that observed in eugonadal BPH patients. Triggering hBPH cells by inflammatory stimuli (tumor necrosis factor α, lipopolysaccharide, or CD4+T cells) induced abundant secretion of inflammatory/growth factors (interleukin 6 (IL6), IL8, and basic fibroblast growth factor (bFGF)). Co-culture of CD4+T cells with hBPH cells induced secretion of Th1 inducer (IL12), Th1-recruiting chemokine (interferon γ inducible protein 10, IP10), and Th2 (IL9)- and Th17 (IL17)-specific cytokines. Pretreatment with DHT inhibited NF-κB activation and suppressed secretion of several inflammatory/growth factors, with the most pronounced effects on IL8, IL6, and bFGF. Reduced inflammatory cytokine production by testosterone cells, an increase in IL10, and a significant reduction of testosterone cells proliferation suggested that DHT exerted a broad antiinflammatory effect on testosterone cells. In conclusion, our data demonstrate that DHT exerts an immune regulatory role on human prostatic stromal cells, inhibiting their potential to actively induce and/or sustain autoimmune and inflammatory responses.

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