Molecular epidemiology of and vaccine development against foot-and-mouth disease virus in Hong Kong

2004 ◽  
Author(s):  
Kin-hi, Raymond Hui
Keyword(s):  
Hong Kong ◽  
Molecular Epidemiology ◽  
Disease Virus ◽  
Vaccine Development ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Evolution and molecular epidemiology of foot-and-mouth disease virus in China

2011 ◽  
Vol 56 (21) ◽  
pp. 2191-2201 ◽  
Author(s):  
XingWen Bai ◽  
PingHua Li ◽  
HuiFang Bao ◽  
ZaiXin Liu ◽  
Dong Li ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Enhanced Stability of Inactivated Foot-And-Mouth Disease Virus Vaccine With A Novel Solution Buffer.

2021 ◽  
Author(s):  
Jing Li ◽  
Yanming Wei ◽  
Rong Zhang ◽  
Huiqing Yang ◽  
Xuerong Liu
Keyword(s):  
Disease Virus ◽  
Virus Vaccine ◽  
Vaccine Development ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Size Exclusion ◽  
Basic Solution ◽  
The Novel ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Abstract Objectives: Stability is vital for potency of food-and-mouth disease virus vaccine preparation. However, the assembly of inactivated foot-and-mouth disease virus is poor stable and prone to dissociate into 12s under mild acidic or heating conditions, especially emulsified with oil-adjuvant. Thus, it is crucial to explore a suitable medium and condition to improve the stability and efficiency of inactivated FMDV vaccine. Results: In this study, the basic solution buffer and a serious of potential stabilizers, such as carbohydrate, amino acid, antioxidant, salt and antioxidant were screened for evaluating stable effect on FMDV antigen with aid of high performance size exclusion chromatography (HPSEC). On this basis, orthogonal experiment was performed to optimize and finally confirm the formulation. Anti-aging test were carried out to asses the efficiency of formulation on vaccine stability and the results showed that the vaccine was more stabler either stored at 37℃or 4℃. Moreover, physicochemical monitoring revealed that formulation had no influence on the properties of vaccine. The combined results suggested that the novel solution buffer would lower degradation and prolong shelf life of vaccine. In a word, the novel buffer is beneficial to make FMD vaccine more stable and effective, reducing the dependence on cold delivery and storage. This study also provides insight into the processes of optimization and inactivated vaccine development.

VP1 sequencing protocol for foot and mouth disease virus molecular epidemiology

2016 ◽  
Vol 35 (3) ◽  
pp. 741-755 ◽  
Author(s):  
N.J. KNOWLES ◽  
J. WADSWORTH ◽  
K. BACHANEK-BANKOWSKA ◽  
D.P. KING
Keyword(s):  
Molecular Epidemiology ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth
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