Studies on Lewis acid-promoted radical cyclization reactions

2002 ◽  
Author(s):  
Shen Gu
Keyword(s):  
Lewis Acid ◽  
Radical Cyclization ◽  
Cyclization Reactions

Lewis Acid Promoted Phenylseleno Group Transfer Tandem Radical Cyclization Reactions

2002 ◽  
Vol 4 (7) ◽  
pp. 1239-1241 ◽  
Author(s):  
Dan Yang ◽  
Qiang Gao ◽  
On-Yi Lee
Keyword(s):  
Lewis Acid ◽  
Radical Cyclization ◽  
Cyclization Reactions ◽  
Group Transfer

Enantioselective PhSe-Group-Transfer Tandem Radical Cyclization Reactions Catalyzed by a Chiral Lewis Acid

2006 ◽  
Vol 45 (2) ◽  
pp. 255-258 ◽  
Author(s):  
Dan Yang ◽  
Bao-Fu Zheng ◽  
Qiang Gao ◽  
Shen Gu ◽  
Nian-Yong Zhu
Keyword(s):  
Lewis Acid ◽  
Radical Cyclization ◽  
Cyclization Reactions ◽  
Group Transfer ◽  
Chiral Lewis Acid

Enantioselective PhSe-Group-Transfer Tandem Radical Cyclization Reactions Catalyzed by a Chiral Lewis Acid.

ChemInform ◽  
2006 ◽  
Vol 37 (21) ◽  
Author(s):  
Dan Yang ◽  
Bao-Fu Zheng ◽  
Qiang Gao ◽  
Shen Gu ◽  
Nian-Yong Zhu
Keyword(s):  
Lewis Acid ◽  
Radical Cyclization ◽  
Cyclization Reactions ◽  
Group Transfer ◽  
Chiral Lewis Acid

Enantioselective PhSe-Group-Transfer Tandem Radical Cyclization Reactions Catalyzed by a Chiral Lewis Acid

2006 ◽  
Vol 118 (2) ◽  
pp. 261-264 ◽  
Author(s):  
Dan Yang ◽  
Bao-Fu Zheng ◽  
Qiang Gao ◽  
Shen Gu ◽  
Nian-Yong Zhu
Keyword(s):  
Lewis Acid ◽  
Radical Cyclization ◽  
Cyclization Reactions ◽  
Group Transfer ◽  
Chiral Lewis Acid

scholarly journals Activation modes in biocatalytic radical cyclization reactions

2021 ◽  
Author(s):  
Yuxuan Ye ◽  
Haigen Fu ◽  
Todd K Hyster
Keyword(s):  
Heme Iron ◽  
Radical Cyclization ◽  
Cytochrome P450 Monooxygenases ◽  
Radical Cyclizations ◽  
Cyclization Reactions ◽  
Complex Molecules ◽  
P450 Monooxygenases ◽  
Non Heme Iron ◽  
Essential Reactions ◽  
Isopenicillin N

Abstract Radical cyclizations are essential reactions in the biosynthesis of secondary metabolites and the chemical synthesis of societally valuable molecules. In this review, we highlight the general mechanisms utilized in biocatalytic radical cyclizations. We specifically highlight cytochrome P450 monooxygenases (P450s) involved in the biosynthesis of mycocyclosin and vancomycin, non-heme iron- and α-ketoglutarate-dependent dioxygenases (Fe/αKGDs) used in the biosynthesis of kainic acid, scopolamine, and isopenicillin N, and radical S-adenosylmethionine (SAM) enzymes that facilitate the biosynthesis of oxetanocin A, menaquinone, and F420. Beyond natural mechanisms, we also examine repurposed flavin-dependent ‘ene’-reductases (ERED) for non-natural radical cyclization. Overall, these general mechanisms underscore the opportunity for enzymes to augment and enhance the synthesis of complex molecules using radical mechanisms.

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