An experimental study on the fasting ketosis in pregnant rats, with special reference to the influence of progesterone on carbohydrate metabolism during pregnancy

1970 ◽  
Author(s):  
Mei-po, Mabel Yang
Keyword(s):  
Experimental Study ◽  
Special Reference ◽  
Carbohydrate Metabolism ◽  
Pregnant Rats

scholarly journals Obligatory Nitrogen Losses in Pregnant Rats with Special Reference to Estimation of Net Protein Utilization.

1992 ◽  
Vol 38 (5) ◽  
pp. 493-499
Author(s):  
Sadaichi SAKAMOTO ◽  
Masahiro MORI ◽  
Masaharu OHNAKA ◽  
Yoshiaki NIIYAMA
Keyword(s):  
Special Reference ◽  
Nitrogen Losses ◽  
Pregnant Rats ◽  
Protein Utilization ◽  
Net Protein

Is it Possible to Prevent Cleft Palate by Prenatal Administration of Folic Acid? An Experimental Study

2001 ◽  
Vol 38 (4) ◽  
pp. 393-398 ◽  
Author(s):  
Volker Bienengräber ◽  
Fathi A. Malek ◽  
Klaus-Uwe Möritz ◽  
Jochen Fanghänel ◽  
Karsten K. H. Gundlach ◽  
...  
Keyword(s):  
Experimental Study ◽  
Folic Acid ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Caesarian Section ◽  
Control Group ◽  
Fetal Head ◽  
Pregnant Rats ◽  
Experimentally Induced

Objective: In this study, folic acid was tested for its antiteratogenic effects on experimentally induced cleft palate in animals. Design: Eleven pregnant Lew 1 A dams (75 fetuses) received 200 mg/kg procarbazine via gastric tubing on postconception (p.c.) day 14 to induce a cleft palate (CP); seven of the pregnant dams (45 fetuses) were additionally given 4 mg/kg folic acid subcutaneously from the 14th to the 17th day p.c. As a control group, three more pregnant dams (24 fetuses) were not treated with the drugs mentioned above. All fetuses were delivered by Caesarian section on day 20 p.c. Outcomes measured: All fetuses were weighed and examined macroscopically with a stereomicroscope. Each fetal head was cut into 35 frontal sections and scrutinized histologically. Results: None of the control fetuses (n = 24) exhibited a cleft. Without folate administration, 90% of the fetuses (27 of 30) that received procarbazine exhibited a CP. After additional prenatal folate administration, this rate remained virtually unchanged (91%; 41 of 45). However, the proportion of complete (total) CP (4%) was significantly (p < .0001) lower than in the group without folate (53%). Cleft-associated microgenia and microglossia were also significantly less frequent when folate was administered prenatally: microgenia was reduced by 22% (p = .029) and microglossia by 24% (p = .032). Conclusions: On the basis of these results, folate has a partial ameliorating effect on the teratogenicity of procarbazine given to pregnant rats. Additional studies are necessary on the effect of folate in different species, also taking cleft lip and CP into consideration.

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