Quantitative studies of the intrahepatic microcirculation in the normal liver and in the acute necrotic and cirrhotic liver induced by carbon tetrachloride

1976 ◽  
Author(s):  
Yee-shan, Isabella Liang
Keyword(s):  
Carbon Tetrachloride ◽  
Normal Liver ◽  
Cirrhotic Liver ◽  
Quantitative Studies

scholarly journals Desmosine and isodesmosine contents and elastase activity in normal and cirrhotic rat liver

1983 ◽  
Vol 214 (3) ◽  
pp. 1023-1025 ◽  
Author(s):  
V Velebný ◽  
E Kasafírek ◽  
J Kanta
Keyword(s):  
Amino Acids ◽  
Carbon Tetrachloride ◽  
Rat Liver ◽  
Congo Red ◽  
Normal Liver ◽  
Cirrhotic Liver ◽  
Cross Linking ◽  
Elastase Activity ◽  
The Cross

The contents of desmosine and isodesmosine, the cross-linking amino acids of elastin, were increased 4-fold in rat liver with carbon tetrachloride-induced cirrhosis, which suggests that insoluble elastin accumulates in cirrhosis. Elastase activity in the cirrhotic liver, as determined with 3-carboxypropionyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide, was 17% less than in the normal liver; no change was found when Congo Red-elastin was used as a substrate.

scholarly journals AN EXPERIMENTAL STUDY INTO THE CAUSE OF THE INCREASED PORTAL PRESSURE IN PORTAL CIRRHOSIS

1907 ◽  
Vol 9 (1) ◽  
pp. 93-104 ◽  
Author(s):  
Frederick C. Herrick
Keyword(s):  
Arterial Pressure ◽  
Portal Pressure ◽  
Normal Liver ◽  
Volume Flow ◽  
Cirrhotic Liver ◽  
Return Flow ◽  
Hepatic Veins ◽  
Portal Cirrhosis ◽  
Arterial Inflow ◽  
Flow Through

1. In the liver of portal cirrhosis there is a far freer communication between the arterial and portal currents than in the normal liver. 2. Factors contributing to the increased portal pressure in portal cirrhosis are (1) the direct communication of the arterial pressure to the portal vessels through dilated capillaries, (2) the larger volume-flow of the hepatic artery in proportion to the portal flow in cirrhosis as compared to that in the normal liver. 3. A portal cirrhotic liver gives passage to an amount of portal fluid proportionate to .its weight. There is no obstruction to the portal vessels from fibrosis in the large portal cirrhotic liver. 4. From an arterial inflow there is a free return flow through the portal as well as through the hepatic veins in both normal and cirrhotic livers. 5. From a portal inflow the return is through the hepatic vein only. The Gad's theory of valves and the arterial capillary network account for this fact. 6. The portal pressure has a decided influence on the arterial volume-flow and vice versa. This influence is more marked in the cirrhotic than in the normal liver. 7. The communication of the arterial pressure to the portal pressure is an important factor in an explanation of the increased portal pressure in portal cirrhosis.

scholarly journals Detection of cirrhosis through ultrasound imaging by intensity difference technique

2019 ◽  
Vol 2019 (1) ◽  
Author(s):  
Karan Aggarwal ◽  
Manjit Singh Bhamrah ◽  
Hardeep Singh Ryait
Keyword(s):  
High Performance ◽  
Research Work ◽  
Region Of Interest ◽  
Normal Liver ◽  
Cirrhotic Liver ◽  
Intensity Difference ◽  
Non Invasive ◽  
The Us ◽  
The Difference ◽  
Two Parameters

Abstract Cirrhosis is a liver disease that is considered to be among the most common diseases in healthcare. Due to its non-invasive nature, ultrasound (US) imaging is a widely accepted technology for the diagnosis of this disease. This research work proposed a method for discriminating the cirrhotic liver from normal liver through US images. The liver US images were obtained from the radiologist. The radiologist also specified the region of interest (ROI) from these images, and then the proposed method was applied to it. Two parameters were extracted from the US images through differences in intensity of neighboring pixels. Then, these parameters can be used to train a classifier by which cirrhotic region of test patient can be detected. A 2-D array was created by the difference in intensity of the neighboring pixels. From this array, two parameters were calculated. The decision was taken by checking these parameters. The validation of the proposed tool was done on 80 images of cirrhotic and 30 images of normal liver, and classification accuracy of 98.18% was achieved. The result was also verified by the radiologist. The results verified its possibility and applicability for high-performance cirrhotic liver discrimination.

scholarly journals Different Effects of Carbon Tetrachloride on Carcinogen-induced Hepatocellular Carcinoma and Normal Liver of the Rat: Lowered Lipid Feroxidation and Accelerated Necrosis in Cancer

1991 ◽  
Vol 82 (5) ◽  
pp. 503-510 ◽  
Author(s):  
Nirush Lertprasertsuke ◽  
Masayuki Shinoda ◽  
Susumu Takekoshi ◽  
Yutaka Tsutsumi ◽  
Yorihiro Yamamoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carbon Tetrachloride ◽  
Normal Liver

scholarly journals Hepatoprotective Effects of Chinese Medicine Herbs Decoction on Liver Cirrhosis in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Nor Aziyah Mat-Rahim ◽  
Tong-Hye Lim ◽  
Nur-Asyura Nor-Amdan ◽  
Sazaly AbuBakar
Keyword(s):  
Body Weight ◽  
Liver Cirrhosis ◽  
Liver Enzymes ◽  
Normal Liver ◽  
Cirrhotic Liver ◽  
Albino Rats ◽  
Gamma Glutamyl Transferase ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Glutamyl Transferase

Hepatoprotective and curative activities of aqueous extract of decoction containing 10 Chinese medicinal herbs (HPE-XA-08) were evaluated in Sprague–Dawley albino rats with liver damage induced by thioacetamide (TAA). These activities were assessed by investigating the liver enzymes level and also histopathology investigation. Increases in alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) levels were observed in rats with cirrhotic liver. No significant alterations of the liver enzymes were observed following treatment with HPE-XA-08. Histopathology examination of rats treated with HPE-XA-08 at 250 mg/kg body weight, however, exhibited moderate liver protective effects. Reduced extracellular matrix (ECM) proteins within the hepatocytes were noted in comparison to the cirrhotic liver. The curative effects of HPE-XA-08 were observed with marked decrease in the level of ALP (more than 3x) and level of GGT (more than 2x) in cirrhotic rat treated with 600 mg/kg body weight HPE-XA-08 in comparison to cirrhotic rat treated with just water diluent. Reversion of cirrhotic liver to normal liver condition in rats treated with HPE-XA-08 was observed. Results from the present study suggest that HPE-XA-08 treatment assisted in the protection from liver cirrhosis and improved the recovery of cirrhotic liver.

scholarly journals Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10.

1996 ◽  
Vol 16 (3) ◽  
pp. 1157-1168 ◽  
Author(s):  
B P Chen ◽  
C D Wolfgang ◽  
T Hai
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Carbon Tetrachloride ◽  
Cyclic Amp ◽  
Normal Liver ◽  
The Other ◽  
Interacting Protein ◽  
Ccl4 Treatment ◽  
Cyclic Amp Response Element ◽  
Injured Liver

We demonstrate that ATF3, a member of the ATF/CREB family of transcription factors, is induced in a variety of stressed tissues: mechanically injured liver, toxin-injured liver, blood-deprived heart, and postseizure brain. We also demonstrate that an ATF3-interacting protein, gadd153/Chop10, forms a nonfunctional heterodimer with ATF3: the heterodimer, in contrast to the ATF3 homodimer, does not bind to the ATF/cyclic AMP response element consensus site and does not repress transcription. Interestingly, ATF3 and gadd153/Chop10 are expressed in inverse but overlapping manners during the liver's response to carbon tetrachloride (CCl4): the level of gadd153/Chop10 mRNA is high in the normal liver and greatly decreases upon CCl4 treatment; the level of ATF3 mRNA, on the other hand, is low in the normal liver and greatly increases upon CCl4 treatment. We hypothesize that in nonstressed liver, gadd153/Chop10 inhibits the limited amount of ATF3 by forming an inactive heterodimer with it, whereas in CCl4-injured liver, the synthesis of gadd153/Chop10 is repressed, allowing the induced ATF3 to function.

Changes in concentrations of respiratory components and cytochrome oxidase activity in mitochondria obtained from carbon tetrachloride-induced cirrhotic rat liver

1988 ◽  
Vol 74 (5) ◽  
pp. 485-489 ◽  
Author(s):  
Taisuke Morimoto ◽  
Akira Tanaka ◽  
Yoshiro Taki ◽  
Masashi Noguchi ◽  
Naoki Yokoo ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Cytochrome Oxidase ◽  
Cytochrome B ◽  
Rat Liver ◽  
Coenzyme Q10 ◽  
Oxidase Activity ◽  
Energy Charge ◽  
Mitochondrial Protein ◽  
Cirrhotic Liver ◽  
Cytochrome Oxidase Activity

1. Changes in the concentrations of respiratory components, phosphorylative activity, the cytochrome oxidase activity of mitochondria and the hepatic adenylate energy charge level (in situ) were studied in cirrhotic rat liver induced by carbon tetrachloride (CCl4). 2. In the cirrhotic liver mitochondria, concentrations of cytochrome a(+ a3), cytochrome b, coenzyme Q9 and coenzyme Q10 increased significantly to 2.44 ± 0.02 × 10−10 (mean ± se), 1.37 ± 0.05 × 10−10, 25.57 ± 0.47 × 10−10 and 5.39 ± 0.26 × 10−10 mol/mg of mitochondrial protein, respectively, compared with 1.83 ± 0.03 × 10−10, 1.22 ± 0.02 × 10−10, 16.24 ± 0.39 × 10−10 and 1·81 ± 0.07 × 10−10 in normal rats [P < 0.001 for cytochrome a(+ a3), coenzyme Q9 and coenzyme Q10, and P < 0.01 for cytochrome b]. 3. Concentrations of flavoprotein and pyridine nucleotides decreased significantly to 13.33 ± 0.14 × 10−10 and 45.68 ± 1.59 × 10−10 mol/mg of mitochondrial protein, respectively, compared with 14.79 ± 0.33 × 10−10 and 86.26 ± 1.83 × 10−10 in normal rats (P < 0.001). There was no significant difference in the concentration of cytochrome c(+ c1). 4. Cytochrome oxidase activity per unit of cytochrome a(+ a3) increased significantly to 67.43 ± 1.71 atoms O s−1 mol−1, compared with 55.77 ± 1.16 in normal rats (P < 0.001). By contrast, phosphorylative activity per unit of cytochrome a(+ a3) decreased significantly in the cirrhotic liver to 10.40 ± 0.36 s−1 compared with 13.43 ± 0.49 in normal rats (P < 0.001). The total adenine nucleotide concentration and the hepatic energy charge level decreased significantly in the cirrhotic liver to 3.420 ± 0.075 μmol/g of wet liver and 0.806 ± 0.003, respectively, compared with 3·854 ± 0.088 and 0.841 ± 0.004 in normal rats (P < 0.001). 5. It is concluded that in mitochondria obtained from CCl4-induced cirrhotic rat liver in which the energy charge level is decreased, cytochrome oxidase activity per unit of cytochrome a(+ a3) is increased in association with an increase in cytochrome a(+ a3) concentration.

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