Excessive ovarian response during in-vitro fertilisation treatment

2004 ◽  
Author(s):  
Hung-yu, Ernest Ng
Keyword(s):  
Ovarian Response ◽  
In Vitro Fertilisation ◽  
Fertilisation Treatment

Low level of basal testosterone: a significant risk factor for poor oocyte yield after ovulation induction

2016 ◽  
Vol 28 (3) ◽  
pp. 286 ◽  
Author(s):  
Jing Guo ◽  
Qingxue Zhang ◽  
Yu Li ◽  
Wenjun Wang ◽  
Dongzi Yang
Keyword(s):  
Risk Factor ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Ovarian Response ◽  
Dehydroepiandrosterone Sulfate ◽  
In Vitro Fertilisation ◽  
Poor Ovarian Response ◽  
Oocyte Yield ◽  
Fertilisation Treatment

The objective of this study was to further investigate the association of low androgen levels and poor ovarian response or negative pregnancy outcome in in vitro fertilisation treatment using a retrospective cohort study. Chinese women (n = 1950) of relatively young age, with normal range of basal FSH and antral follicle count undergoing an in vitro fertilisation cycle were selected and testosterone and dehydroepiandrosterone sulfate levels were measured on Day 3 of the menstrual cycle before subsequent in vitro fertilisation treatment. The main outcome measures of the study were ovarian stimulation parameters and clinical pregnancy. Basal testosterone levels of poor responders and non-pregnant women were significantly lower than normal responders and pregnant women, respectively. Patients with low basal testosterone levels had significantly lower number of mature oocytes, cleavage-stage embryos, frozen embryos, lower fertilisation and pregnancy rates and required higher doses of gonadotrophins. Androgen levels had no correlation with early spontaneous abortion rates. Multivariable logistic analysis revealed that low basal testosterone (<0.88 nmol L–1) was an independent risk factor for poor oocyte yield (odds ratio: 1.61; 95% confidence interval: 1.01–2.57; P = 0.045). In conclusion, a low level of basal testosterone was a significant risk factor for poor oocyte yield after ovarian stimulation and might negatively influence pregnancy chances with in vitro fertilisation. Basal dehydroepiandrosterone sulfate levels were not predictive for poor ovarian response or negative pregnancy outcome in this population.

scholarly journals Men report good mental health 20 to 23 years after in vitro fertilisation treatment

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Gunilla Sydsjö ◽  
Josefin Vikström ◽  
Marie Bladh ◽  
Barbara Jablonowska ◽  
Agneta Skoog Svanberg
Keyword(s):  
Mental Health ◽  
In Vitro Fertilisation ◽  
Good Mental Health ◽  
Fertilisation Treatment

Progesterone elevation on the day of oocyte retrieval and live birth rate after in vitro fertilisation treatment

2021 ◽  
pp. 1-5
Author(s):  
Maria Angeles Roque Fernandez ◽  
Cristina Alvarez Lleo ◽  
Esteban Gonzalez Mirasol ◽  
Maria Resta Serra ◽  
Carmen Garcia Garrido ◽  
...  
Keyword(s):  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Oocyte Retrieval ◽  
In Vitro Fertilisation ◽  
Fertilisation Treatment

scholarly journals Pilot study: Alternative spliced variants of the Follicle-Stimulating Hormone Receptor gene in Greek women undergoing In Vitro Fertilisation (IVF)

2019 ◽  
Vol 18 (4) ◽  
pp. 155-162
Author(s):  
Eudoxia Mamas ◽  
Despoina Mavrogianni ◽  
Rami Raouasnte ◽  
Spyros Karkatzoulis ◽  
Emmanouela Liokari ◽  
...  
Keyword(s):  
Ovarian Stimulation ◽  
Hormone Receptor ◽  
Splice Variants ◽  
Receptor Gene ◽  
Ovarian Response ◽  
Cumulus Cells ◽  
Response To Treatment ◽  
In Vitro Fertilisation ◽  
Nucleotide Polymorphisms

Assisted Reproduction Technology (ART) has proven to be a valuable tool for infertile couples. Unfortunately, no perfect ovarian stimulation protocol has been designed and ovarian response shows great variability among women. Pharmacogenomics aims at detecting genetic markers so as to individualize protocols in order to maximize ovarian response to treatment. Follicle Stimulation hormone receptor (FSHR) mutations and single nucleotide polymorphisms have been extensively studied. Splice variants of the FSHR have been detected in women undergoing in vitro fertilisation (IVF). This study aims to determine the presence FSH splice variants in Greek women undergoing IVF. RNA was extracted from cumulus cells from 35 women and analysed by real time PCR. Splice variants were detected by gel electrophoresis. Three cases of deletion of exon 9 and 2 cases of insertion of intron 8 were detected in our study group. No association between the presence of splice variants and response to ovarian stimulation was detected. Two live births were detected one in each variant group. Even though these two types of splice variant detected do not show any clinical correlation it is believed that variants of the FSHR may be associated with poor or high response to exogenous gonadotrophin so further research is necessary.

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