scholarly journals Role of Nox4 in Neuronal Differentiation of Mouse Subventricular Zone Neural Stem Cells

2016 ◽  
Vol 26 (1) ◽  
pp. 8-16 ◽  
Author(s):  
Ki-Youb Park ◽  
Yerin Na ◽  
Man Su Kim
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Neuronal Differentiation ◽  
Subventricular Zone

scholarly journals Functionalized Nanocellulose Drives Neural Stem Cells toward Neuronal Differentiation

2021 ◽  
Vol 12 (4) ◽  
pp. 64
Author(s):  
Sahitya Chetan Pandanaboina ◽  
Ambar B. RanguMagar ◽  
Krishna D. Sharma ◽  
Bijay P. Chhetri ◽  
Charlette M. Parnell ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Neuronal Differentiation ◽  
Brain Injuries ◽  
Therapeutic Option ◽  
Large Population ◽  
Electrode Array ◽  
Nano Size

Transplantation of differentiated and fully functional neurons may be a better therapeutic option for the cure of neurodegenerative disorders and brain injuries than direct grafting of neural stem cells (NSCs) that are potentially tumorigenic. However, the differentiation of NSCs into a large population of neurons has been a challenge. Nanomaterials have been widely used as substrates to manipulate cell behavior due to their nano-size, excellent physicochemical properties, ease of synthesis, and versatility in surface functionalization. Nanomaterial-based scaffolds and synthetic polymers have been fabricated with topology resembling the micro-environment of the extracellular matrix. Nanocellulose materials are gaining attention because of their availability, biocompatibility, biodegradability and bioactivity, and affordable cost. We evaluated the role of nanocellulose with different linkage and surface features in promoting neuronal differentiation. Nanocellulose coupled with lysine molecules (CNC–Lys) provided positive charges that helped the cells to attach. Embryonic rat NSCs were differentiated on the CNC–Lys surface for up to three weeks. By the end of the three weeks of in vitro culture, 87% of the cells had attached to the CNC–Lys surface and more than half of the NSCs had differentiated into functional neurons, expressing endogenous glutamate, generating electrical activity and action potentials recorded by the multi-electrode array.

scholarly journals The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain

2010 ◽  
Vol 112 (6) ◽  
pp. 1368-1385 ◽  
Author(s):  
Patricia Mathieu ◽  
Daniela Battista ◽  
Amaicha Depino ◽  
Valeria Roca ◽  
Mariana Graciarena ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Neuronal Differentiation ◽  
Functional Role ◽  
Adult Brain

Nestin Regulates Neurogenesis in Mice Through Notch Signaling From Astrocytes to Neural Stem Cells

2019 ◽  
Vol 29 (10) ◽  
pp. 4050-4066 ◽  
Author(s):  
Ulrika Wilhelmsson ◽  
Isabell Lebkuechner ◽  
Renata Leke ◽  
Pavel Marasek ◽  
Xiaoguang Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Notch Signaling ◽  
Neuronal Differentiation ◽  
Long Term Memory ◽  
Hippocampal Dentate Gyrus ◽  
Term Memory ◽  
Behavioral Studies

Abstract The intermediate filament (nanofilament) protein nestin is a marker of neural stem cells, but its role in neurogenesis, including adult neurogenesis, remains unclear. Here, we investigated the role of nestin in neurogenesis in adult nestin-deficient (Nes–/–) mice. We found that the proliferation of Nes–/– neural stem cells was not altered, but neurogenesis in the hippocampal dentate gyrus of Nes–/– mice was increased. Surprisingly, the proneurogenic effect of nestin deficiency was mediated by its function in the astrocyte niche. Through its role in Notch signaling from astrocytes to neural stem cells, nestin negatively regulates neuronal differentiation and survival; however, its expression in neural stem cells is not required for normal neurogenesis. In behavioral studies, nestin deficiency in mice did not affect associative learning but was associated with impaired long-term memory.

scholarly journals Role of miRNAs in Neuronal Differentiation from Human Embryonic Stem Cell—Derived Neural Stem Cells

2012 ◽  
Vol 8 (4) ◽  
pp. 1129-1137 ◽  
Author(s):  
Jing Liu ◽  
Jackline Githinji ◽  
Bridget Mclaughlin ◽  
Kasia Wilczek ◽  
Jan Nolta
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Neural Stem Cells ◽  
Embryonic Stem Cell ◽  
Neuronal Differentiation ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem
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