Generation of red blood cells from pluripotent stem cells as an alternative to donated blood

2012 ◽  
Vol 2012 (1) ◽  
pp. 7
Author(s):  
Joanne Mountford
Keyword(s):  
Stem Cells ◽  
Red Blood Cells ◽  
Pluripotent Stem Cells ◽  
Blood Cells ◽  
Donated Blood

Dna methylation of manufactured red blood cells from human induced pluripotent stem cells

2017 ◽  
Vol 53 ◽  
pp. S111-S112
Author(s):  
Isabel Dorn ◽  
Claudia Bernecker ◽  
Slave Trajanoski ◽  
Holm Zaehres ◽  
Peter Schlenke ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Red Blood Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Blood Cells ◽  
Induced Pluripotent

Generation of human induced pluripotent stem cells from a Bombay individual: Moving towards “universal-donor” red blood cells

2010 ◽  
Vol 391 (1) ◽  
pp. 329-334 ◽  
Author(s):  
Ali Seifinejad ◽  
Adeleh Taei ◽  
Mehdi Totonchi ◽  
Hamed Vazirinasab ◽  
Seideh Nafiseh Hassani ◽  
...  
Keyword(s):  
Stem Cells ◽  
Red Blood Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Blood Cells ◽  
Induced Pluripotent ◽  
Universal Donor

scholarly journals PSC-RED, an Albumin-Free Robust Erythroid Differentiation Method to Produce Enucleated Red Blood Cells from Human Pluripotent Stem Cells

2019 ◽  
Author(s):  
Emmanuel N Olivier ◽  
Shouping Zhang ◽  
Zi Yan ◽  
Sandra Suzuka ◽  
Karl Roberts ◽  
...  
Keyword(s):  
Stem Cells ◽  
Red Blood Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Blood Cells ◽  
Erythroid Differentiation ◽  
Economic Viability ◽  
List Type ◽  
Potential Applications ◽  
Induced Pluripotent

AbstractCultured red blood cells (cRBCs) have many potential applications in transfusion medicine and drug delivery. We report that we have developed chemically defined, albumin-free Robust Erythroid Differentiation (RED) methods to produce enucleated cRBCs from human induced pluripotent stem cells (iPSCs). Human iPSC-derived cRBCs produced with either the short or long variation of the RED protocol respectively express embryonic/fetal or a mixture of fetal and adult hemoglobins. The long version of the protocol produces up to 50% of enucleated cells at an unprecedented yield. RED is scalable and relies on inexpensive components and therefore dramatically increases the feasibility and economic viability of all translational applications of cRBCs.HighlightsPSC-RED: A chemically-defined, albumin-free Robust Erythroid Differentiation (RED) methods to produce cRBCs from human induced pluripotent stem cells.PSC-RED produces up to 50% enucleated cells at an unprecedented yield.PSC-RED is scalable and relies on inexpensive components and therefore increases the feasibility and economic viability of translational applications of cRBCs.

scholarly journals Generation of Red Blood Cells from Human Induced Pluripotent Stem Cells

2011 ◽  
Vol 20 (9) ◽  
pp. 1639-1647 ◽  
Author(s):  
Jessica Dias ◽  
Marina Gumenyuk ◽  
HyunJun Kang ◽  
Maxim Vodyanik ◽  
Junying Yu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Red Blood Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Blood Cells ◽  
Induced Pluripotent

scholarly journals Production of Embryonic and Fetal-Like Red Blood Cells from Human Induced Pluripotent Stem Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e25761 ◽  
Author(s):  
Chan-Jung Chang ◽  
Koyel Mitra ◽  
Mariko Koya ◽  
Michelle Velho ◽  
Romain Desprat ◽  
...  
Keyword(s):  
Stem Cells ◽  
Red Blood Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Blood Cells ◽  
Induced Pluripotent

Red blood cells from pluripotent stem cells for use in transfusion

2010 ◽  
Vol 5 (3) ◽  
pp. 411-423 ◽  
Author(s):  
Joanne C Mountford ◽  
Emmanuel Olivier ◽  
Niove E Jordanides ◽  
Paul de Sousa ◽  
Marc L Turner
Keyword(s):  
Stem Cells ◽  
Red Blood Cells ◽  
Pluripotent Stem Cells ◽  
Blood Cells
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