The iKnife: Analysis of diathermy plumes by high-resolution mass spectrometry provides real-time identification of colorectal cancer liver metastases

2012 ◽  
pp. AESNP7
Author(s):  
Ara Darzi ◽  
Laura J. Muirhead ◽  
László Sasi-Szabó ◽  
Júlia Balog ◽  
Reza Mirnezami ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mass Spectrometry ◽  
High Resolution ◽  
Liver Metastases ◽  
Real Time ◽  
High Resolution Mass Spectrometry ◽  
Colorectal Cancer Liver Metastases ◽  
High Resolution Mass ◽  
Real Time Identification ◽  
Resolution Mass

scholarly journals Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ariadna Martín-Blázquez ◽  
Caridad Díaz ◽  
Encarnación González-Flores ◽  
Daniel Franco-Rivas ◽  
Cristina Jiménez-Luna ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
High Resolution ◽  
Metastatic Colorectal Cancer ◽  
High Resolution Mass Spectrometry ◽  
Healthy Controls ◽  
High Resolution Mass ◽  
Novel Biomarkers ◽  
Resolution Mass

AbstractColorectal cancer is one of the main causes of cancer death worldwide, and novel biomarkers are urgently needed for its early diagnosis and treatment. The utilization of metabolomics to identify and quantify metabolites in body fluids may allow the detection of changes in their concentrations that could serve as diagnostic markers for colorectal cancer and may also represent new therapeutic targets. Metabolomics generates a pathophysiological ‘fingerprint’ that is unique to each individual. The purpose of our study was to identify a differential metabolomic signature for metastatic colorectal cancer. Serum samples from 60 healthy controls and 65 patients with metastatic colorectal cancer were studied by liquid chromatography coupled to high-resolution mass spectrometry in an untargeted metabolomic approach. Multivariate analysis revealed a separation between patients with metastatic colorectal cancer and healthy controls, who significantly differed in serum concentrations of one endocannabinoid, two glycerophospholipids, and two sphingolipids. These findings demonstrate that metabolomics using liquid-chromatography coupled to high-resolution mass spectrometry offers a potent diagnostic tool for metastatic colorectal cancer.

Rapid fingerprinting of source and environmental microplastics using direct analysis in real time-high resolution mass spectrometry

2020 ◽  
Vol 1100 ◽  
pp. 107-117 ◽  
Author(s):  
Xianming Zhang ◽  
Alicia Mell ◽  
Frederick Li ◽  
Clara Thaysen ◽  
Brian Musselman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Real Time ◽  
High Resolution Mass Spectrometry ◽  
Direct Analysis ◽  
High Resolution Mass ◽  
Resolution Mass
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