scholarly journals THE COMPRESSION EFFECT ON AERODYNAMIC PROPERTIES OF DIANA SUBMARINE SWIMSUIT

Author(s):  
Hazim Moria ◽  
Firoz Alam ◽  
Harun Chowdhury ◽  
Aleksandar Subic
2012 ◽  
Vol 34 ◽  
pp. 56-61 ◽  
Author(s):  
Hazim Moria ◽  
Firoz Alam ◽  
Harun Chowdhury ◽  
Aleksandar Subic

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Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 844
Author(s):  
Thorben Fischer ◽  
Inga Winter ◽  
Robert Drumm ◽  
Marc Schneider

The transport of macromolecular drugs such as oligonucleotides into the lungs has become increasingly relevant in recent years due to their high potency. However, the chemical structure of this group of drugs poses a hurdle to their delivery, caused by the negative charge, membrane impermeability and instability. For example, siRNA to reduce tumour necrosis factor alpha (TNF-α) secretion to reduce inflammatory signals has been successfully delivered by inhalation. In order to increase the effect of the treatment, a co-transport of another anti-inflammatory ingredient was applied. Combining curcumin-loaded mesoporous silica nanoparticles in nanostructured cylindrical microparticles stabilized by the layer-by-layer technique using polyanionic siRNA against TNF-α was used for demonstration. This system showed aerodynamic properties suited for lung deposition (mass median aerodynamic diameter of 2.85 ± 0.44 µm). Furthermore, these inhalable carriers showed no acute in vitro toxicity tested in both alveolar epithelial cells and macrophages up to 48 h incubation. Ultimately, TNF-α release was significantly reduced by the particles, showing an improved activity co-delivering both drugs using such a drug-delivery system for specific inhibition of TNF-α in the lungs.


2021 ◽  
Vol 11 (6) ◽  
pp. 2752
Author(s):  
Conchin Contell Asins ◽  
Volker Landersheim ◽  
Dominik Laveuve ◽  
Seiji Adachi ◽  
Michael May ◽  
...  

In order to contribute to achieving noise and emission reduction goals, Fraunhofer and Airbus deal with the development of a morphing leading edge (MLE) as a high lift device for aircraft. Within the European research program “Clean Sky 2”, a morphing leading edge with gapless chord- and camber-increase for high-lift performance was developed. The MLE is able to morph into two different aerofoils—one for cruise and one for take-off/landing, the latter increasing lift and stall angle over the former. The shape flexibility is realised by a carbon fibre reinforced plastic (CFRP) skin optimised for bending and a sliding contact at the bottom. The material is selected in terms of type, thickness, and lay-up including ply-wise fibre orientation based on numerical simulation and material tests. The MLE is driven by an internal electromechanical actuation system. Load introduction into the skin is realised by span-wise stringers, which require specific stiffness and thermal expansion properties for this task. To avoid the penetration of a bird into the front spar of the wing in case of bird strike, a bird strike protection structure is proposed and analysed. In this paper, the designed MLE including aerodynamic properties, composite skin structure, actuation system, and bird strike behaviour is described and analysed.


Author(s):  
A. Takumi Ozawa ◽  
B. Hiroaki Kosuge ◽  
C. Yoshiki Mikami ◽  
D. Tomoya Kawabata

Author(s):  
Camila Freitas Salgueiredo ◽  
Armand Hatchuel

AbstractIs biologically inspired design only an analogical transfer from biology to engineering? Actually, nature does not always bring “hands-on” solutions that can be analogically applied in classic engineering. Then, what are the different operations that are involved in the bioinspiration process and what are the conditions allowing this process to produce a bioinspired design? In this paper, we model the whole design process in which bioinspiration is only one element. To build this model, we use a general design theory, concept–knowledge theory, because it allows one to capture analogy as well as all other knowledge changes that lead to the design of a bioinspired solution. We ground this model on well-described examples of biologically inspired designs available in the scientific literature. These examples include Flectofin®, a hingeless flapping mechanism conceived for façade shading, and WhalePower technology, the introduction of bumps on the leading edge of airfoils to improve aerodynamic properties. Our modeling disentangles the analogical aspects of the biologically inspired design process, and highlights the expansions occurring in both knowledge bases, scientific (nonbiological) and biological, as well as the impact of these expansions in the generation of new concepts (concept partitioning). This model also shows that bioinspired design requires a special form of collaboration between engineers and biologists. Contrasting with the classic one-way transfer between biology and engineering that is assumed in the literature, the concept–knowledge framework shows that these collaborations must be “mutually inspirational” because both biological and engineering knowledge expansions are needed to reach a novel solution.


2010 ◽  
Vol 2 (2) ◽  
pp. 2487-2492 ◽  
Author(s):  
Firoz Alam ◽  
Harun Chowdhury ◽  
Chavaporn Theppadungporn ◽  
Aleksandar Subic

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