P16 Expression in Laryngeal Squamous Cell Carcinoma and its Relationship with Human Papillomavirus

2012 ◽  
Vol 32 (6) ◽  
pp. 1576-1585
Author(s):  
Melahat DÖNMEZ ◽  
Gülben ERDEM HUQ ◽  
Noyan Can AKDUR ◽  
Serap GÖZEL ◽  
Erol Rüştü BOZKURT
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
P16 Expression

Prognostic implications of human papillomavirus status and p16 expression in laryngeal squamous cell carcinoma

Head & Neck ◽  
2019 ◽  
Vol 41 (12) ◽  
pp. 4151-4163 ◽  
Author(s):  
Yingying Zhu ◽  
Xin Xia ◽  
Neil Gross ◽  
Kristina R. Dahlstrom ◽  
Liming Gao ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Implications ◽  
P16 Expression

scholarly journals Prevalence of Human Papillomavirus in Laryngeal Squamous Cell Carcinoma in Azerbaijan Population

2018 ◽  
Vol 03 (01) ◽  
Author(s):  
Aziz J. Aliyev ◽  
Leylakhanim A. Melikova ◽  
Elnara E. Bagirova ◽  
Kamal S. Akbarov ◽  
Aytan M. Aliyeva ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma

scholarly journals Expression Profile of Survivin and p16 in Laryngeal Squamous Cell Carcinoma: Contribution of Tunisian Patients

2019 ◽  
Vol 100 (1) ◽  
pp. NP7-NP15 ◽  
Author(s):  
Mariem Ben Elhadj ◽  
Olfa E. L. Amine ◽  
Nehla Mokni Baizig ◽  
Wided Ben Ayoub ◽  
Aida Goucha ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Significance ◽  
Survivin Expression ◽  
Clinicopathological Parameters ◽  
Therapeutic Protocol ◽  
Tunisian Patients ◽  
P16 Expression

The objective of this study was to evaluate the expression of survivin and p16 in laryngeal squamous cell carcinoma (LSCC) in order to analyze their pathogenesis and prognostic significance in Tunisian patients. A total of 70 patients with LSCC collected at the Salah Azaiez Cancer Institute of Tunis were retrospectively evaluated. Expression of survivin and p16 was examined using immunohistochemistry, and the correlations with clinicopathological parameters, overall survival (OS), and disease-free survival (DFS) were statistically evaluated. The positive expression of survivin and p16 were found in 58.6% and 51.43% of LSCC cases, respectively. The p16 expression was not associated with either clinical parameters or patient survival, whereas there was a strong correlation of survivin expression and lymph node metastases ( P = .002), alcohol consumption ( P = .024), and therapeutic protocol (with or without chemotherapy; P = .001). Kaplan-Meier survival curves showed that patients with LSCC having positive survivin expression have shorter OS ( P = .026) and shorter DFS ( P = .01) than those with negative expression. Positive survivin expression was also correlated with high recurrence rate ( P = .014). Therefore, survivin is a poor prognostic marker for LSCC but the therapeutic protocol remains, in multivariate study, the most decisive for the OS and DFS of our patients with P < .01. Our data indicated that, in Tunisian laryngeal squamous cell carcinoma, survivin expression is associated with unfavorable outcomes and represents a predictor marker of recurrence and chemoresistance. However, p16 expression has no prognosis value.

scholarly journals Human papillomavirus DNA and p16 expression in head and neck squamous cell carcinoma in young French patients

2021 ◽  
Vol 49 (7) ◽  
pp. 030006052110225
Author(s):  
Chloé Molimard ◽  
Virginie L’Huillier ◽  
Alexis Overs ◽  
Christine Soret ◽  
Marie-Paule Algros ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Hpv Infection ◽  
Neck Squamous Cell Carcinoma ◽  
University Hospital ◽  
Hpv Dna ◽  
P16 Expression

Objectives Human papillomavirus (HPV) is a risk factor for head and neck squamous cell carcinoma (HNSCC), which is currently increasing worldwide. We evaluated the prevalence of HPV DNA and p16 expression in HNSCC patients age <45 years compared with patients aged ≥45 years. Methods Thirty-nine patients aged <45 years who presented at Besançon University Hospital with HNSCC since 2005 were included in this retrospective study. HPV DNA was detected by HPV genotyping and p16 expression was determined by immunohistochemistry using paraffin-embedded tissues. A matched-group of 38 patients aged ≥45 years from Besançon University Hospital was included. Results The overall prevalence of HPV infection was 11.7%. HPV16 was the only genotype detected in 4/39 and 5/38 patients, and p16 was expressed in 6/39 and 4/38 patients aged <45 years and ≥45 years, respectively. Conclusions HPV-positivity and p16 expression were similar in both age groups. The results suggest that p16 immunohistochemistry may provide a prognosis biomarker for all HNSCCs, not only oropharyngeal cancers, and this should be addressed in large clinical trials.

Sign in / Sign up

Export Citation Format

Share Document