scholarly journals Obliterative Bronchiolitis in a Lung Transplant

2022 ◽  
Author(s):  
Stefan Tigges
Keyword(s):  
Lung Transplant ◽  
Obliterative Bronchiolitis

scholarly journals Ferret Lung Transplant: An Orthotopic Model of Obliterative Bronchiolitis

2012 ◽  
Vol 13 (2) ◽  
pp. 467-473 ◽  
Author(s):  
H. Sui ◽  
A. K. Olivier ◽  
J. A. Klesney-Tait ◽  
L. Brooks ◽  
S. R. Tyler ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Obliterative Bronchiolitis ◽  
Orthotopic Model

Role of CMV pneumonia in the development of obliterative bronchiolitis in heart-lung and double-lung transplant recipients

1992 ◽  
Vol 5 ◽  
pp. S242-S245 ◽  
Author(s):  
J. Cerrina ◽  
F. Le Roy Ladurie ◽  
P. H. Herve ◽  
F. Parquin ◽  
S. Harari ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Obliterative Bronchiolitis ◽  
Transplant Recipients ◽  
Lung Transplant Recipients

scholarly journals 290 Ferret Lung Transplant: An Orthotopic Model for Obliterative Bronchiolitis

2012 ◽  
Vol 31 (4) ◽  
pp. S104-S105
Author(s):  
H. Sui ◽  
L. Brooks ◽  
J.A. Klesney-Tait ◽  
A. Olivier ◽  
D. Meyerholz ◽  
...  
Keyword(s):  
Lung Transplant ◽  
Obliterative Bronchiolitis ◽  
Orthotopic Model

scholarly journals A Role for Indirect Allorecognition in Lung Transplant Recipients with Obliterative Bronchiolitis

2003 ◽  
Vol 3 (6) ◽  
pp. 736-742 ◽  
Author(s):  
Rachel E. Stanford ◽  
Saed Ahmed ◽  
Margaret Hodson ◽  
Nicholas R. Banner ◽  
Marlene L. Rose
Keyword(s):  
Lung Transplant ◽  
Obliterative Bronchiolitis ◽  
Transplant Recipients ◽  
Indirect Allorecognition ◽  
Lung Transplant Recipients

Oligoclonal CD4+T Cell Expansions in Lung Transplant Recipients with Obliterative Bronchiolitis

2002 ◽  
Vol 165 (10) ◽  
pp. 1439-1444 ◽  
Author(s):  
Steven R. Duncan ◽  
Colm Leonard ◽  
James Theodore ◽  
Mark Lega ◽  
Reda E. Girgis ◽  
...  
Keyword(s):  
T Cell ◽  
Lung Transplant ◽  
Cd4 T Cell ◽  
Obliterative Bronchiolitis ◽  
Transplant Recipients ◽  
Lung Transplant Recipients

scholarly journals The role of autoimmunity in obliterative bronchiolitis after lung transplantation

2013 ◽  
Vol 304 (5) ◽  
pp. L307-L311 ◽  
Author(s):  
Daniel J. Weber ◽  
David S. Wilkes
Keyword(s):  
Lung Transplantation ◽  
Lung Transplant ◽  
Transplant Rejection ◽  
Survival Rates ◽  
Bronchiolitis Obliterans Syndrome ◽  
Obliterative Bronchiolitis ◽  
Definitive Treatment ◽  
Limiting Factor ◽  
Solid Organ

First performed in the 1960s with long-term successes achieved in the 1980s, lung transplantation remains the only definitive treatment option for end-stage lung disease. Chronic lung rejection, pathologically classified as obliterative bronchiolitis (OB) with its clinical correlate referred to as bronchiolitis obliterans syndrome, is the limiting factor than keeps 5-yr survival rates for lung transplant significantly worse than for other solid organ transplants. Initially, OB was largely attributed to immune responses to donor antigens, alloimmunity. However, more recent work has demonstrated the role of autoimmunity in the process of lung transplant rejection. IL-17 and autoantigens such as collagen type V and K-α1 tubulin have been implicated in the development of chronic rejection. Ultimately, this translational review discusses the role that autoimmunity plays in the development of OB and lung transplant rejection and then discusses options for therapeutic intervention.

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