scholarly journals Pancreas adenocarcinoma - body

2021 ◽  
Author(s):  
Michael Hartung
Keyword(s):  
Pancreas Adenocarcinoma

scholarly journals Pharmacologic modulation of 5-fluorouracil by folinic acid and high-dose pyridoxine for treatment of patients with digestive tract carcinomas

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
David Machover ◽  
Wathek Almohamad ◽  
Vincent Castagné ◽  
Christophe Desterke ◽  
Léa Gomez ◽  
...  
Keyword(s):  
Folinic Acid ◽  
Digestive Tract ◽  
Vitamin B6 ◽  
Colorectal Adenocarcinoma ◽  
High Dose ◽  
High Concentration ◽  
Carcinoma Of The Esophagus ◽  
Pancreas Adenocarcinoma ◽  
The Impact ◽  
High Dose Vitamin

AbstractSupplementation of cancer cells exposed to 5-fluorouracil (FUra) and folinic acid (FA) with high concentration pyridoxal 5′-phosphate, the cofactor of vitamin B6, potentiates the cytotoxicity of FUra in a synergistic interaction mode. We report a pilot study in 13 patients with previously untreated advanced carcinoma of the digestive tract to assess the impact of high-dose pyridoxine (PN) on the antitumor activity of regimens comprising FUra and FA. Five patients had colorectal adenocarcinoma (CRC); 5 had pancreas adenocarcinoma (PC); and 3 had squamous cell carcinoma of the esophagus (EC). Patients with CRC and with PC received oxaliplatin, irinotecan, FUra and FA, and patients with EC had paclitaxel, carboplatin, FUra and FA. PN iv from 1000 to 3000 mg/day preceded each administration of FA and FUra. Eleven patients responded. Two patients with CRC attained CRs and 3 had PRs with reduction rates ≥ 78%. Two patients with PC attained CRs, and 2 had PRs with reduction rates ≥ 79%. Responders experienced disappearance of most metastases. Of 3 patients with EC, 2 attained CRs. Median time to attain a response was 3 months. Unexpected toxicity did not occur. Results suggest that high-dose vitamin B6 enhances antitumor potency of regimens comprising FUra and FA.

Pancreas Adenocarcinoma and Ampullary Cancer

2016 ◽  
pp. 105-128
Author(s):  
Chad Barnes ◽  
Kathleen K. Christians ◽  
Douglas B. Evans ◽  
Susan Tsai
Keyword(s):  
Ampullary Cancer ◽  
Pancreas Adenocarcinoma

scholarly journals Impact of surgical wait time on postoperative and oncological outcomes in resectable pancreas adenocarcinoma

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S121
Author(s):  
E. Vasilyeva ◽  
J. Li ◽  
S. Desai ◽  
S. Khaola ◽  
A.K. Buczkowski ◽  
...  
Keyword(s):  
Wait Time ◽  
Oncological Outcomes ◽  
Pancreas Adenocarcinoma ◽  
Surgical Wait Time

scholarly journals Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: The importance of surface sialyl Lewisa antigen

1996 ◽  
Vol 69 (4) ◽  
pp. 290-294 ◽  
Author(s):  
Takashi Kishimoto ◽  
Hiroshi Ishikura ◽  
Chisa Kimura ◽  
Toshiyuki Takahashi ◽  
Hiroyuki Kato ◽  
...  
Keyword(s):  
Pancreas Adenocarcinoma ◽  
Sialyl Lewisa

Health-related quality of life and pain assessment in 36 patients with resected pancreas adenocarcinoma: Preliminary analysis

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e20692-e20692
Author(s):  
B. I. Carr ◽  
D. Summers ◽  
L. Menefee ◽  
S. Pierpoint ◽  
C. Yeo ◽  
...  
Keyword(s):  
Tumor Size ◽  
Pearson Correlation ◽  
Brief Pain Inventory ◽  
Well Being ◽  
Pain Severity ◽  
Pathology Report ◽  
Disease Extent ◽  
Pancreas Adenocarcinoma ◽  
Related Quality ◽  
Health Related

e20692 Background: In order to begin to understand the effects of disease on the patient (pt) and possibly of the pt on the disease, we have begun a systematic psychological inventory of all our pts who have has a pancreatectomy for pancreas adenocarcinoma and have began to correlate this with disease extent, and later with survival. Methods: Prior to post-op discharge home, pts were invited to fill out a brief pain inventory (BPI-SF), BPI interference, emotional (EWB) and physical well-being score (Fact-Hep), as well as social/family and functional well-being (FWB) Fact-Hep. The data was entered into a database, together with pertinent lab results, tumor markers, and tumor characteristics from the pre-op CT scan and post-op pathology report. Data was analyzed by descriptive statistics, frequencies and Pearson Correlation (2-tailed sig). Results: Descriptive means (and ranges) were - tumor size 3.43 cm mean (2.0 min-5.2 max), bilirubin 1.26 (0.2–4.7), albumin 2.69 (1.5–3.6), Hb 10.3 (7.5–13.2), platelets 254K (109K-672K), CEA 4.7 (0.8–24), and Ca 19–9 was 987 (1.0–8127). Pain at presentation pre-op of moderate severity was present in 11% of pts and severe pain was present in 5.6% of pts (16.6% total). Pathologically, LNs were involved by cancer in 50% of pts, vascular invasion in 30%, neural invasion in 35% and any margin positive in 14%. 22% had metastases noted at surgery. Statistically significant correlations were found for tumor size and pain severity (p<.035), platelets and FWB (p<.022), albumin and Hb (p=.000), CA 19–9 and bilirubin (p<.030 i.e. high CA 19–9 and high bilirubin). There was a negative correlation between CEA (but not CA 19–9) and both EWB (p<.039) and FWB (p<.035). Pain severity correlated with depressed mood (p<.010), lower physical well-being (p<.01) and interference with life activities (p<.01). Conclusions: CEA, but not CA 19–9 correlated with both emotional and functional well-being. Baseline pain was present in only 16.6% of this cohort. We plan to follow up to examine how these parameters correlate with pt coping throughout therapy and survival. No significant financial relationships to disclose.

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