Acute methanol poisoning

The Treatment of Methanol Poisoning with Ethanol; With Report of Two Cases

Quarterly Journal of Studies on Alcohol ◽

10.15288/qjsa.1949.9.515 ◽

1949 ◽

Vol 9 (4) ◽

pp. 515-522 ◽

Cited By ~ 17

Author(s):

Kjell Agner ◽

Olle Höök ◽

Bertil von Porat

Keyword(s):

Methanol Poisoning

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COVID-19 and Alcohol Poisoning: A Fatal Competition

Disaster Medicine and Public Health Preparedness ◽

10.1017/dmp.2021.89 ◽

2021 ◽

pp. 1-10

Author(s):

Mohammad Heidari ◽

Nasrin Sayfouri

Keyword(s):

Side Effects ◽

Alcohol Consumption ◽

Mass Media ◽

The Body ◽

Ministry Of Health ◽

Alcohol Poisoning ◽

Methanol Poisoning ◽

The Public

ABSTRACT In March 2020, concurrently with the outbreak of COVID-19 in Iran, the rate of alcohol poisoning was unexpectedly increased in the country. This study has attempted to make an overall description and analysis of this phenomenon by collecting credible data from the field, news, and reports published by the emergency centers and the Iranian Ministry of Health. The investigations showed that in May 20, 2020, more than 6150 people have been affected by methanol poisoning from whom 804 deaths have been reported. A major cause of the increased rate of alcohol poisoning in this period was actually the illusion that alcohol could eliminate the Coronaviruses having entered the body. It is of utmost importance that all mass media try to dismiss the cultural, religious, and political considerations and prepare convincing programs to openly discuss the side-effects of forged alcohol consumption with the public, especially with the youth. It must be clearly specified that “consuming alcohol cannot help prevent COVID-19.”

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Formate test for bedside diagnosis of methanol poisoning

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/bcpt.13597 ◽

2021 ◽

Author(s):

Knut Erik Hovda ◽

Yvonne Elisabeth Lao ◽

Gaut Gadeholt ◽

Dag Jacobsen

Keyword(s):

Methanol Poisoning ◽

Bedside Diagnosis

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Methanol poisoning caused by inhalation of solvent

Nefrología (English Edition) ◽

10.1016/j.nefroe.2018.03.013 ◽

2018 ◽

Vol 38 (6) ◽

pp. 679-680 ◽

Cited By ~ 1

Author(s):

Carmen Robledo ◽

Ramón Saracho

Keyword(s):

Methanol Poisoning

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A Case of Optic Nerve Atrophy with Severe Disc Cupping after Methanol Poisoning

Korean Journal of Ophthalmology ◽

10.3341/kjo.2011.25.2.146 ◽

2011 ◽

Vol 25 (2) ◽

pp. 146 ◽

Cited By ~ 8

Author(s):

Yong Woon Shin ◽

Ki Bang Uhm

Keyword(s):

Optic Nerve ◽

Optic Nerve Atrophy ◽

Methanol Poisoning

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Ranitidine as an alcohol dehydrogenase inhibitor in acute methanol toxicity in rats

Human & Experimental Toxicology ◽

10.1177/0960327109353777 ◽

2009 ◽

Vol 29 (2) ◽

pp. 93-101 ◽

Cited By ~ 8

Author(s):

Amal A El-Bakary ◽

Sahar A El-Dakrory ◽

Sohayla M Attalla ◽

Nawal A Hasanein ◽

Hala A Malek

Keyword(s):

Alcohol Dehydrogenase ◽

High Performance ◽

Negative Control Group ◽

Positive Control ◽

Negative Control ◽

Control Group ◽

Sprague Dawley ◽

Blood Samples ◽

Methanol Poisoning ◽

Sprague Dawley Rats

Methanol poisoning is a hazardous intoxication characterized by visual impairment and formic acidemia. The therapy for methanol poisoning is alcohol dehydrogenase (ADH) inhibitors to prevent formate accumulation. Ranitidine has been considered to be an inhibitor of both gastric alcohol and hepatic aldehyde dehydrogenase enzymes. This study aimed at testing ranitidine as an antidote for methanol acute toxicity and comparing it with ethanol and 4-methyl pyrazole (4-MP). This study was conducted on 48 Sprague-Dawley rats, divided into 6 groups, with 8 rats in each group (one negative control group [C1], two positive control groups [C2, C3] and three test groups [1, 2 and 3]). C2, C3 and all test groups were exposed to nitrous oxide by inhalation, then, C3 group was given methanol (3 g/kg orally). The three test groups 1, 2 and 3 were given ethanol (0.5 g/kg orally), 4-MP (15 mg/kg intraperitoneally) and ranitidine (30 mg/kg intraperitoneally), respectively, 4 hours after giving methanol. Rats were sacrificed and heparinized, cardiac blood samples were collected for blood pH and bicarbonate. Non-heparinized blood samples were collected for formate levels by high performance liquid chromatography. Eye balls were enucleated for histological examination of the retina. Ranitidine corrected metabolic acidosis (p = .025), decreased formate levels (p = .014) and improved the histological findings in the retina induced by acute methanol toxicity.

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