Vertebral metastases and pathological fracture, no cord compression

2021 ◽  
Author(s):  
Frances Colgan
Keyword(s):  
Pathological Fracture ◽  
Cord Compression ◽  
Vertebral Metastases

scholarly journals Symptomatic Vertebral Hemangioma in a Young Child

2017 ◽  
Vol 08 (03) ◽  
pp. 458-460
Author(s):  
William Martin ◽  
Ravi Rajmohan ◽  
Muhittin Belirgen
Keyword(s):  
Spinal Cord ◽  
Rare Case ◽  
Tumor Tissue ◽  
Pathological Fracture ◽  
Cord Compression ◽  
Vertebral Hemangioma ◽  
Tumor Removal ◽  
Vertebral Hemangiomas ◽  
Pathological Report

ABSTRACTVertebral hemangiomas (VHs) are the most common benign vertebral neoplasm and typically are asymptomatic, only to be discovered incidentally on imaging from the fourth to fifth decade of life. Seldom do they enlarge to a point of compression, causing pain and focal neurologic deficits. We present the rare case of an 8-year-old female who presented with paraparesis after a fall. Imaging revealed a pathological fracture of the T8 vertebra with retropulsion and spinal cord compression from both fracture and epidural tumor tissue. The patient underwent an anterior and posterior removal of the tumor, decompression, and fusion. Pathological report of specimen biopsy confirmed a benign hemangioma. To the best of our knowledge, this is the same age as the youngest previously reported case of symptomatic VH and it is the longest to be recurrence-free at follow-up. The hemangioma was successfully treated with tumor removal, decompression, and fusion. No adjuvant treatment was required, and she remained asymptomatic without recurrence at her 4-year follow-up.

scholarly journals Morphological Verification Of Malignant Neoplasm Of The Urinary System With Multiple Bone Metastases

2021 ◽  
Vol 03 (06) ◽  
pp. 145-149
Author(s):  
Shakhanova Shakhnoza Shavkatovna ◽  
◽  
Nodir Mahammatkulovich Rakhimov ◽  
Keyword(s):  
Spinal Cord ◽  
Renal Cell Carcinoma ◽  
Bone Metastases ◽  
Pathological Fracture ◽  
Malignant Neoplasm ◽  
Cord Compression ◽  
Urinary System ◽  
Common Site ◽  
Bone Surgery ◽  
Multiple Bone Metastases

In metastatic renal cell carcinoma (mRCC), bone is the second most common site of metastases, occurring in one third of patients. Most bone metastases are found in the sacrum, pelvis, spine and proximal limbs. In addition, the majority of bone metastases are osteolytic with elements of destruction; mixed metastases also occur. This predisposes patients to skeletal events such as pathological fracture, spinal cord compression, which implies the prescription of radiation therapy or bone surgery.

Impact of skeletal-related events on survival in patients with prostate cancer metastatic to bones.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 223-223
Author(s):  
Jean A. McDougall ◽  
Bernardo Haddock Lobo Goulart ◽  
Sean D Sullivan ◽  
Jeannine S. McCune ◽  
Aasthaa Bansal ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Metastatic Prostate Cancer ◽  
Pathological Fracture ◽  
Cord Compression ◽  
Time Dependent ◽  
Risk Of Death ◽  
Skeletal Related Events ◽  
The Impact

223 Background: Skeletal related events (SREs), defined as pathological fracture, spinal cord compression, surgery or radiotherapy to the bone, occur in nearly half of men diagnosed with metastatic prostate cancer. Accurate assessment of the risk of death associated with SREs is important to making decisions about the use of recently approved treatments, which have been shown to decrease the frequency of skeletal events, yet estimating the impact of SREs on survival presents several methodological challenges given the recurrent time-dependent nature of exposure. Methods: A cohort of men >65years of age, diagnosed with prostate cancer and bone metastasis between January 1, 2004 and December 31, 2009 was identified from the Surveillance Epidemiology and End Results (SEER) registries were linked to Medicare Parts A and B claims. The outcome of interest, death from any cause, was ascertained from SEER and survival time was calculated from the date of metastatic prostate cancer diagnosis. Multivariable Cox proportional hazards models treating the occurrence of an SRE as a time-dependent exposure were used to estimate the hazard ratios (HR) and corresponding 95% confidence intervals (CI) for the association between SRE occurrence, number, and type, and death. Results: Among 3,297 men with metastatic prostate cancer, 40% experienced ≥1 SRE during the observational follow-up period (median 19 months). Compared to men who remained SRE-free, cohort members who had ≥1 SREs had a two-fold higher risk of death (HR 2.2, 95% CI 2.0-2.4). Those whose first SRE was a pathological fracture had a 2.7-fold higher risk of death (HR 2.7, 95% CI 2.3-3.1), followed by spinal cord compression (HR 2.1, 95% CI 1.8-2.5), surgery (HR 1.8, 95% CI 1.5-2.2) and radiotherapy (HR 2.2, 95% CI 1.9-2.4). Compared to those experiencing only one SRE, men who experienced a second SRE of any type had double the risk of death (HR 2.2, 95% CI 1.9-2.6). Conclusions: SREs were associated with ≥50% reduction in overall survival. This finding is consistent across different types of SREs and supports using therapies to prevent or treat SREs in patients with prostate cancer metastatic to the bones.

scholarly journals Palliative Radiation Therapy for Vertebral Metastases and Metastatic Cord Compression in Patients Treated With Anti-PD-1 Therapy

2019 ◽  
Vol 9 ◽  
Author(s):  
Muhammad Mohsin Fareed ◽  
Luke R. G. Pike ◽  
Andrew Bang ◽  
Mai Anh Huynh ◽  
Allison Taylor ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cord Compression ◽  
Vertebral Metastases ◽  
Palliative Radiation ◽  
Palliative Radiation Therapy

scholarly journals Vertebral Metastases with High Risk of Symptomatic Malignant Spinal Cord Compression

2009 ◽  
Vol 39 (7) ◽  
pp. 431-434 ◽  
Author(s):  
Y. Hamamoto ◽  
M. Kataoka ◽  
T. Senba ◽  
K. Uwatsu ◽  
Y. Sugawara ◽  
...  
Keyword(s):  
Spinal Cord ◽  
High Risk ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Vertebral Metastases

Vertebral Metastases and Spinal Cord Compression

2009 ◽  
pp. 1247-1260 ◽  
Author(s):  
Nora Janjan ◽  
Edward Lin ◽  
Ian McCutcheon ◽  
George Perkins ◽  
Prajnan Das ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Vertebral Metastases

Neurosurgical treatment of pathological fracture-dislocation of the spine

1980 ◽  
Vol 52 (3) ◽  
pp. 330-334 ◽  
Author(s):  
Richard G. Perrin ◽  
Kenneth E. Livingston
Keyword(s):  
Satisfactory Result ◽  
Pathological Fracture ◽  
Spinal Metastases ◽  
Cord Compression ◽  
Fracture Dislocation ◽  
Content Type ◽  
Time Of Surgery ◽  
Average Survival ◽  
Neurosurgical Treatment ◽  
Upper Thoracic

✓ The treatment of 20 patients with symptomatic pathological fracture-dislocation of the spine is reviewed. The single most common primary disease was carcinoma of the breast (12 cases). Pain was the presenting symptom in 19 patients. At the time of surgery, six patients were weak but ambulatory, seven were bedridden, and three were paraplegic. The cervical spine (10 cases) was most frequently involved, followed by the thoracic region in six, and the lumbar segments in four. Treatment aimed at improving or preserving neurological function involved decompression of the cord (or cauda) with reduction of bone deformity and stabilization of the spine. Laminectomy decompression was performed in 18 cases. Posterior rib graft fusion was used to stabilize the spine in all patients with cervical, and in three with upper thoracic, pathological fracture-dislocation; Harrington rod instrumentation was used for lower thoracic and lumbar levels. All patients were considered for radiotherapy and/or chemotherapy. Ten patients are living, an average of 20 months following surgery. Among the remainder, the average survival was 5 months. Fourteen patients were ambulatory after surgery, four were improved, and two were unchanged. Twelve patients have achieved a “satisfactory” result (walking and continent 6 months after treatment), including the three who were paraplegic at the time of surgery. Spinal metastases presenting as pathological fracture-dislocation of the spine may produce potentially devastating cord compression. Critical neurological sequelae can be avoided, and a satisfactory result can be achieved by urgent decompression of the cord and stabilization of the spine.

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