scholarly journals Trousseau syndrome

2021 ◽  
Author(s):  
Ali Alsmair
Keyword(s):  
Trousseau Syndrome

scholarly journals Mechanical Thrombectomy for Trousseau Syndrome in a Terminally Ill Cancer Patient

2019 ◽  
Vol 57 (3) ◽  
pp. 688-694 ◽  
Author(s):  
Naoto Kuroda ◽  
Hisaya Hiramatsu ◽  
Masanori Mori ◽  
Tokutaro Tanaka
Keyword(s):  
Cancer Patient ◽  
Mechanical Thrombectomy ◽  
Terminally Ill ◽  
Trousseau Syndrome

scholarly journals Multiple extra-ischemic hemorrhages following intravenous thrombolysis in a patient with Trousseau syndrome: case study

SpringerPlus ◽  
2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Hiroyuki Ikeda ◽  
Rei Enatsu ◽  
Norikazu Yamana ◽  
Masaki Nishimura ◽  
Masaaki Saiki
Keyword(s):  
Intravenous Thrombolysis ◽  
Trousseau Syndrome

Multiple Thrombi in the Heart in Trousseau Syndrome Caused by Pancreatic Carcinoma

2018 ◽  
Vol 27 (5) ◽  
pp. e75-e77 ◽  
Author(s):  
Sho Takeshita ◽  
Toshiyasu Ogata ◽  
Hidekazu Mera ◽  
Jun Tsugawa ◽  
Mikiko Aoki ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Trousseau Syndrome

scholarly journals Trousseau syndrome in a patient with advanced oral squamous cell carcinoma: a case report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Ken-ichi Aoyama ◽  
Masashi Tamura ◽  
Masahiro Uchibori ◽  
Yasuhiro Nakanishi ◽  
Toshihiro Arai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Trousseau Syndrome

Non-bacterial thrombotic endocarditis in a Trousseau syndrome patient with stomach cancer: A case report

2016 ◽  
Vol 16 (10) ◽  
pp. 1171-1172
Author(s):  
Satoru Morimoto ◽  
Jun Tanaka ◽  
Yoko Saito ◽  
Naoko Tsuyama ◽  
Takashi Nishimura ◽  
...  
Keyword(s):  
Case Report ◽  
Stomach Cancer ◽  
Syndrome Patient ◽  
Trousseau Syndrome

scholarly journals Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome

Blood ◽  
2011 ◽  
Vol 118 (15) ◽  
pp. 4015-4023 ◽  
Author(s):  
Bojing Shao ◽  
Mark G. Wahrenbrock ◽  
Longbiao Yao ◽  
Tovo David ◽  
Shaun R. Coughlin ◽  
...  
Keyword(s):  
Murine Model ◽  
Knockout Mice ◽  
Fluid Phase ◽  
Cell Types ◽  
Src Family Kinases ◽  
Cathepsin G ◽  
Trousseau Syndrome ◽  
Bidirectional Signaling ◽  
Blocking Antibodies ◽  
Deficient Mice

Abstract Trousseau syndrome is classically defined as migratory, heparin-sensitive but warfarin-resistant microthrombi in patients with occult, mucinous adenocarcinomas. Injecting carcinoma mucins into mice generates platelet-rich microthrombi dependent on P- and L-selectin but not thrombin. Heparin prevents mucin binding to P- and L-selectin and mucin-induced microthrombi. This model of Trousseau syndrome explains resistance to warfarin, which inhibits fluid-phase coagulation but not selectins. Here we found that carcinoma mucins do not generate microthrombi in mice lacking P-selectin glycoprotein ligand-1 (PSGL-1), the leukocyte ligand for P- and L-selectin. Furthermore, mucins did not activate platelets in blood from PSGL-1–deficient mice. Mucins induced microthrombi in radiation chimeras lacking endothelial P-selectin but not in chimeras lacking platelet P-selectin. Mucins caused leukocytes to release cathepsin G, but only if platelets were present. Mucins failed to generate microthrombi in cathepsin G-deficient mice. Mucins did not activate platelets in blood from mice lacking cathepsin G or protease-activated receptor-4 (PAR4), indicating that cathepsin G activates platelets through PAR4. Using knockout mice and blocking antibodies, we found that mucin-triggered cathepsin G release requires L-selectin and PSGL-1 on neutrophils, P-selectin on platelets, and Src family kinases in both cell types. Thus, carcinoma mucins promote thrombosis through adhesion-dependent, bidirectional signaling in neutrophils and platelets.

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