scholarly journals Diffuse glioma classification (WHO 5th Edition, 2021)

2021 ◽  
Author(s):  
Frank Gaillard
Keyword(s):  
Diffuse Glioma ◽  
Glioma Classification

scholarly journals Prognostic significance of MGMT promoter methylation in diffuse glioma patients

2019 ◽  
Vol 33 (1) ◽  
pp. 639-644
Author(s):  
Nikola Jovanović ◽  
Tatjana Mitrović ◽  
Vladimir J. Cvetković ◽  
Svetlana Tošić ◽  
Jelena Vitorović ◽  
...  
Keyword(s):  
Promoter Methylation ◽  
Prognostic Significance ◽  
Mgmt Promoter Methylation ◽  
Diffuse Glioma ◽  
Mgmt Promoter

NEAT1 Is a Novel Oncogenic LncRNA and Correlated with miR-143 in Pediatric Oligodendrogliomas

2021 ◽  
Vol 56 (2) ◽  
pp. 133-139
Author(s):  
Secil Ak Aksoy ◽  
Melis Mutlu ◽  
Rabia Nur Balcin ◽  
Mevlut Ozgur Taskapilioglu ◽  
Cagla Tekin ◽  
...  
Keyword(s):  
Noncoding Rna ◽  
Expression Profiles ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Pediatric Brain Tumors ◽  
Normal Brain ◽  
Diffuse Glioma ◽  
Expression Levels ◽  
Treatment Models ◽  
New Treatment

Introduction: The noncoding RNAs (ncRNAs) play a role in biological processes of various cancers including gliomas. The majority of these transcripts are uniquely expressed in differentiated tissues or specific glioma types. Pediatric oligodendroglioma (POG) is a rare subtype of diffuse glioma and accounts for <1% of pediatric brain tumors. Because histologically POG resembles adult OG, the same treatment is applied as adults. However, the significance in predicting outcomes in POG patients is unclear. In this study, we aimed to investigate the prognostic significance of expression ­profiles of microRNA (miRNA) and long noncoding RNA ­(LncRNA) in POGs. Methods: We investigated the levels of 13 known miRNAs and 6 LncRNAs in tumor samples from 9 patients with primary POG by using RT-PCR and analyzed their association with outcomes. Results: The expression levels of miR-21, miR-106a, miR-10b, and LncRNA NEAT1 were higher, and the expression level of miR-143 was lower in POG tissues compared with normal brain tissues (p = 0.006, p = 0.032, p = 0.034, p = 0.002, and p = 0.001, respectively). High levels of NEAT1 and low expression of miR-143 were associated with decreased probability of short disease-free survival (p = 0.018 and p = 0.022, respectively). Discussion: NEAT1 and miR-143 levels could serve as reciprocal prognostic predictors of disease progression in patients with POG. New treatment models to regulate the expression levels of NEAT1 and miR-143 will bring a new approach to the therapy of POG.

Comprehensive exploration of tumor mutational burden and immune infiltration in diffuse glioma

2021 ◽  
Vol 96 ◽  
pp. 107610
Author(s):  
Kai Kang ◽  
Fucun Xie ◽  
Yijun Wu ◽  
Zhile Wang ◽  
Li Wang ◽  
...  
Keyword(s):  
Diffuse Glioma ◽  
Immune Infiltration ◽  
Mutational Burden ◽  
Tumor Mutational Burden

scholarly journals Diffuse Glioma manifesting as Normal Pressure Hydrocephalus: A potential pitfall in diagnosis-a case report

2021 ◽  
pp. 100009
Author(s):  
Marianthi Breza ◽  
Vasiliki Kotsali-Peteinelli ◽  
Ioanna Tsantzali ◽  
Antonis Mavromatos ◽  
Eleni Strataki ◽  
...  
Keyword(s):  
Case Report ◽  
Normal Pressure Hydrocephalus ◽  
Normal Pressure ◽  
Diffuse Glioma ◽  
Potential Pitfall

scholarly journals Evidence-based recommendations on categories for extent of resection in diffuse glioma

2021 ◽  
Vol 149 ◽  
pp. 23-33
Author(s):  
Philipp Karschnia ◽  
Michael A. Vogelbaum ◽  
Martin van den Bent ◽  
Daniel P. Cahill ◽  
Lorenzo Bello ◽  
...  
Keyword(s):  
Extent Of Resection ◽  
Evidence Based ◽  
Diffuse Glioma

Clinical implications of molecular analysis in diffuse glioma stratification

2021 ◽  
Author(s):  
Masahiro Mizoguchi ◽  
Nobuhiro Hata ◽  
Daisuke Kuga ◽  
Ryusuke Hatae ◽  
Yojiro Akagi ◽  
...  
Keyword(s):  
Molecular Analysis ◽  
Clinical Implications ◽  
Diffuse Glioma

scholarly journals Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1542 ◽  
Author(s):  
Digregorio Marina ◽  
Lombard Arnaud ◽  
Lumapat Paul Noel ◽  
Scholtes Felix ◽  
Rogister Bernard ◽  
...  
Keyword(s):  
Translation Initiation ◽  
Protein Production ◽  
Therapeutic Potential ◽  
Environmental Stressors ◽  
Current Therapy ◽  
Diffuse Glioma ◽  
Overall Survival Rate ◽  
Malignant Cells ◽  
Translational Machinery ◽  
Initiation Step

Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize proteins required to promote their survival, even in times of high physiological and pathological stress. This phenomenon has been described in several cancers including in gliomas. Abnormal regulation of translation has encouraged the development of new therapeutics targeting the protein synthesis pathway. This approach could be meaningful for glioma given the fact that the median survival following diagnosis of the highest grade of glioma remains short despite current therapy. The identification of new targets for the development of novel therapeutics is therefore needed in order to improve this devastating overall survival rate. This review discusses current literature on translation in gliomas with a focus on the initiation step covering both the cap-dependent and cap-independent modes of initiation. The different translation initiation protagonists will be described in normal conditions and then in gliomas. In addition, their gene expression in gliomas will systematically be examined using two freely available datasets. Finally, we will discuss different pathways regulating translation initiation and current drugs targeting the translational machinery and their potential for the treatment of gliomas.

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