scholarly journals Anaplastic meningioma

2021 ◽  
Author(s):  
Claudia Sanchez
Keyword(s):  
Anaplastic Meningioma

Carcinomatous meningitis in a case of anaplastic meningioma

1995 ◽  
Vol 23 (3) ◽  
pp. 239-243 ◽  
Author(s):  
Matthieu Vinchon ◽  
Marie-Madeleine Ruchoux ◽  
Jean-Paul Lejeune ◽  
Richard Assaker ◽  
Jean-Louis Christiaens
Keyword(s):  
Carcinomatous Meningitis ◽  
Anaplastic Meningioma

scholarly journals TMOD-21. TARGETING ANAPLASTIC MENINGIOMA WITH PANOBINOSTAT IN PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODELS DERIVED FROM A MATCHING PAIR OF PRIMARY AND RECURRENT TUMORS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi267-vi267
Author(s):  
Huiyuan Zhang ◽  
Lin Qi ◽  
Yuchen Du ◽  
Frank Braun ◽  
Mari Kogiso ◽  
...  
Keyword(s):  
Skull Base ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Small Animal ◽  
Tumor Formation ◽  
Anaplastic Meningioma ◽  
Culture Cells ◽  
Pathologic Features ◽  
Two Samples

Abstract BACKGROUND Meningioma is the most common brain tumor in adults. Despite the overall benign nature of meningioma, skull base tumors can be difficult to completely resect while others exhibit progression and aggressive profiles. The lack of clinically relevant animal models is blocking the development of novel therapies. MATERIAL AND METHODS Twelve surgical specimens (1 × 105) from 11 adult meningioma patients were implanted into the frontal cranial-base of the brain of SCID mice. Mice were then followed and assessed for tumor formation. Tumor growth was confirmed by small animal MRI. Pathologic features of the PDOX models and the matched patient tumors were compared with standard H&E and immunohistochemical staining. RNAseq was performed to examine the molecular fidelity of PDOX tumors and to identify new therapeutic targets. A panel of 60 clinically-relevant drugs was developed for screening drug sensitivity. In vivo examination of therapeutic efficacy of Panobinostat was performed in two models by treating preformed PDOX tumors with i.p. injection (10 mg/kg), 5 days on, 5 days off for 2 cycles. RESULTS Intracranial xenograft formation was confirmed in two samples derived from the same patient, the first an atypical meningioma (K029MEN-P) and the second, which progressed to anaplastic meningioma at recurrence (K029MEN-R). MRI scanning revealed that the PDOX tumors grew from the skull base. These patient tumor cells can be cryopreserved for long-term maintenance of tumorigenicity. The xenograft tumors replicated histopathological features of parental tumors. Overall gene expression profiles of PDOX were similar to the original patient tumors. Using MEN primary culture cells, we screened 60 drugs and identified 12 (20%) active compounds. Panobinostat also significantly prolonged survival of mice bearing orthotopic meningiomas. CONCLUSION A set of meningioma PDOX models derived from primary and recurrent tumor was established. Our data further demonstrate that panobinostat exerts potent antitumor activity against high-grade meningioma.

Lateral Intraventricular Anaplastic Meningioma: A Series of 5 Patients at a Single Institution and Literature Review

2019 ◽  
Vol 131 ◽  
pp. e1-e11
Author(s):  
Hongxu Chen ◽  
Rui Lai ◽  
Xinpu Tang ◽  
Zhiyong Liu ◽  
Jianguo Xu
Keyword(s):  
Literature Review ◽  
Single Institution ◽  
Anaplastic Meningioma

scholarly journals Apatinib in recurrent anaplastic meningioma: a retrospective case series and systematic literature review

2020 ◽  
Vol 21 (7) ◽  
pp. 583-589 ◽  
Author(s):  
Yong Wang ◽  
Wenke Li ◽  
Nianliang Jing ◽  
Xiangji Meng ◽  
Shizhen Zhou ◽  
...  
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Case Series ◽  
Retrospective Case ◽  
Anaplastic Meningioma ◽  
Retrospective Case Series

scholarly journals Extracranial metastases of anaplastic meningioma

2017 ◽  
Vol 3 (2) ◽  
pp. 20150092
Author(s):  
Robbin Zachery Thomas ◽  
Ishani Dalal
Keyword(s):  
Anaplastic Meningioma ◽  
Extracranial Metastases

scholarly journals Extensive Growth of an Anaplastic Meningioma

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Hajrullah Ahmeti ◽  
Homajoun Maslehaty ◽  
Athanasios K. Petridis ◽  
Alexandros Doukas ◽  
Mehran Mahvash ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Tumor Resection ◽  
High Rate ◽  
Complete Tumor Resection ◽  
Calvarial Bone ◽  
Anaplastic Meningioma ◽  
Progressive Ataxia ◽  
Extensive Growth ◽  
Tumor Entity ◽  
Complete Tumor

We present the case of a 30-year-old male patient with an almost complete destruction of the calvarial bone through an anaplastic meningioma diagnosed in line with dizziness. Neuroimaging revealed an extensive growing, contrast enhancing lesion expanding at the supra- and infratentorial convexity, infiltrating and destroying large parts of the skull, and infiltrating the skin. Due to progressive ataxia and dysarthria with proven tumor growth in the posterior fossa in the continuing course, parts of the tumor were resected. A surgical procedure with the aim of complete tumor resection in a curative manner was not possible. Six months after the first operation, due to a new tumor progression, most extensive tumor resection was performed. Due to the aggressive and destructive growth with a high rate of recurrence and tendency of metastases, anaplastic meningiomas can be termed as malignant tumors. The extrinsic growth masks the tumor until they reach a size, which makes these tumors almost unresectable. In the best case scenarios, the five-year survival is about 50%. With the presented case, we would like to show the aggressive behavior of anaplastic meningiomas in a very illustrative way. Chemotherapy, radiotherapy, and surgery reach their limits in this tumor entity.

Anaplastic meningioma with papillary, rhabdoid, and epithelial features: a case report

2001 ◽  
Vol 18 (2) ◽  
pp. 155-159 ◽  
Author(s):  
Atsushi Saito ◽  
Yoichi Nakazato ◽  
Yoshihiko Yoshii ◽  
Akio Hyodo ◽  
Tsuyoshi Harakuni ◽  
...  
Keyword(s):  
Case Report ◽  
Anaplastic Meningioma
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