scholarly journals Chronic vs acute osteomyelitis (illustration)

2021 ◽  
Author(s):  
Henry Knipe ◽  
David Gendy
Keyword(s):  
Acute Osteomyelitis

Acute Osteomyelitis in Children: A Population-based Retrospective Study 1965 to 1994

1998 ◽  
Vol 30 (6) ◽  
pp. 573-577 ◽  
Author(s):  
Lauritz B. Dahl ◽  
Anne-Lise Høyland ◽  
Harald Dramsdahl ◽  
Per Ivar Kaaresen
Keyword(s):  
Retrospective Study ◽  
Population Based ◽  
Acute Osteomyelitis

Decisive Diagnosis of Infected Mandibular Osteoradionecrosis with a Tc-99m-labelled Anti-granulocyte Fab′-fragment

1999 ◽  
Vol 38 (07) ◽  
pp. 309-311 ◽  
Author(s):  
W. Brenner ◽  
H. Terheyden ◽  
K. H. Bohuslavizki ◽  
E. Henze ◽  
W. U. Kampen
Keyword(s):  
Blood Pool ◽  
Bone Scanning ◽  
Acute Osteomyelitis ◽  
Elevated Blood ◽  
Fab Fragment ◽  
Postoperative Changes ◽  
Three Phase ◽  
Golden Standard ◽  
Blood Pool Activity ◽  
Bone Inflammation

SummaryThe accepted golden standard for detection of inflammatory bone disease is conventional three-phase bone scanning. Hyperperfusion, a high blood-pool activity and elevated bone metabolism are typical signs for an acute osteomyelitis. However, in case of subacute, chronic inflammation, neither elevated blood flow nor high blood-pool activity may be seen. This may cause difficulties in differentiating such cases from neoplastic or postoperative changes. This case report verifies the possible advantage of immunoscintigraphy with Tc-99m-labelled antigranulocyte Fab′-fragments (LeukoScan®) in a patient with infected mandibular osteoradionecrosis, who had equivocal clinical symptomes and questionable radiographic results. LeukoScan® is shown to be more sensitive in case of subacute bone inflammation compared with three-phase bone scanning. However, acquisition of delayed images after 24 hours including SPECT is inevitable in case of negative scans during the first hours of investigation.

scholarly journals 329. Performance of Next Generation Sequencing in Isolating a Pathogen in Pediatric Osteoarticular Infections

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S236-S237
Author(s):  
Nanda Ramchandar ◽  
Jessica Burns ◽  
Andrew Pennock ◽  
Christopher R Cannavino ◽  
Lauge Farnaes
Keyword(s):  
Next Generation Sequencing ◽  
Septic Arthritis ◽  
Standard Care ◽  
Pediatric Population ◽  
Single Site ◽  
Acute Osteomyelitis ◽  
Next Generation ◽  
Pathogenic Organism ◽  
Osteoarticular Infections ◽  
Generation Sequencing

Abstract Background Osteoarticular infections are often encountered in the pediatric population. Therapy is guided by isolation of a putative organism, however, operative cultures are often negative. Next generation sequencing (NGS) allows for more sensitive sampling of body compartments generally considered sterile. We sought to evaluate the utility of NGS in comparison to culture in detecting a pathogenic organism in acute osteomyelitis and septic arthritis in children. Methods This was a single-site study to evaluate the utility of NGS in comparison to culture in detecting a pathogenic organism in acute osteomyelitis and septic arthritis in children. Eligible patients were all patients with osteomyelitis or septic arthritis admitted to Rady Children’s Hospital from July 2019 through July 2020. We excluded any patients with bone or joint surgery within 30 days prior to admission. Operative samples were chosen at the surgeon’s discretion (joint aspirate, synovium, or bone) based on operative findings. We compared NGS testing to standard care culture from the same site. Results We enrolled 41 subjects. NGS of the operative samples identified a pathogen in 26 (63.4%) patients versus 18 (43.9%) by culture. Operative culture missed the diagnosis in 10 cases, though PCR identified the organism in 6 of those cases (5 were cases in which Kingella kingae was identified). In 4 subjects, NGS identified a putative organism where standard care testing (either PCR or culture) was negative. NGS was falsely positive in 1 subject and falsely negative for one other subject. Sensitivity was 96.3% (CI 95%, 81.0–99.9%) and Specificity was 92.9% (CI 95%, 66.1–99.8) for NGS versus 64.3% (CI 95%, 44.1–81.4) and 84.6% (CI 95%, 54.6–99.9%) for culture respectively. Conclusion In this single site prospective study of pediatric osteoarticular infections, we demonstrate improved sensitivity and specificity of NGS testing when compared to standard culture. Disclosures All Authors: No reported disclosures

Treatment of Acute Osteomyelitis

BMJ ◽  
1962 ◽  
Vol 2 (5306) ◽  
pp. 736-737
Author(s):  
T. S. Subrahmanyan
Keyword(s):  
Acute Osteomyelitis

Acute osteomyelitis: advantage of white cell scans in early detection

1982 ◽  
Vol 139 (6) ◽  
pp. 1077-1082 ◽  
Author(s):  
V Raptopoulos ◽  
PW Doherty ◽  
TP Goss ◽  
MA King ◽  
K Johnson ◽  
...  
Keyword(s):  
Early Detection ◽  
White Cell ◽  
Acute Osteomyelitis

Pitfalls in the Diagnosis of Acute Osteomyelitis by Bone Scan

1980 ◽  
Vol 19 (9) ◽  
pp. 597-600 ◽  
Author(s):  
Ellen R. Wald ◽  
Robert Mirro ◽  
J. Carlton Gartner
Keyword(s):  
Bone Scan ◽  
Acute Osteomyelitis
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