scholarly journals Well-differentiated liposarcoma/atypical lipomatous tumour

2020 ◽  
Author(s):  
Joachim Feger
Keyword(s):  
Lipomatous Tumour ◽  
Well Differentiated

scholarly journals Primary Small Bowel Liposarcoma (Atypical Lipomatous Tumour) with Myogenic Differentiation

Sarcoma ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
J. Patel ◽  
R. Deb ◽  
W. Speake ◽  
T. A. MacCulloch
Keyword(s):  
Small Bowel ◽  
Bowel Wall ◽  
Myogenic Differentiation ◽  
Iliac Fossa ◽  
Current Case ◽  
Lipomatous Tumour ◽  
Small Intestinal ◽  
Well Differentiated ◽  
The Right ◽  
Primary Small Bowel

Primary small intestinal liposarcomas originating in the small bowel are uncommon with a generally poor prognosis due to the advanced stage at the time of diagnosis. We describe a case of primary small bowel dedifferentiated liposarcoma presenting as a solid mass in the right iliac fossa. The current case is unusual as the tumour seemingly originated from the bowel and the well-differentiated component was seen extensively infiltrating the bowel wall including the small bowel submucosa.

scholarly journals Pilot study to differentiate lipoma from atypical lipomatous tumour/well-differentiated liposarcoma using MR radiomics-based texture analysis

2020 ◽  
Vol 49 (11) ◽  
pp. 1719-1729 ◽  
Author(s):  
Ian Pressney ◽  
Michael Khoo ◽  
Raymond Endozo ◽  
Balaji Ganeshan ◽  
Paul O’Donnell
Keyword(s):  
Pilot Study ◽  
Texture Analysis ◽  
Lipomatous Tumour ◽  
Well Differentiated

A REVIEW ON LIPOMA AND ITS GENETIC INTERVENTIONS

2020 ◽  
pp. 6-10
Author(s):  
Jisa Elizabath Sabu ◽  
Bharat Mishra ◽  
Angelin Jaimon Augustine ◽  
Aleesha R
Keyword(s):  
Adipocyte Differentiation ◽  
Chromosome Region ◽  
Fatty Tissue ◽  
Over Expression ◽  
Mesenchymal Neoplasms ◽  
Lipomatous Tumour ◽  
Polymerase Chain ◽  
Genetic Interventions ◽  
Well Differentiated ◽  
Complex Chromosome

Lipomas are benign soft tissue fatty tumours that most commonly appear in the third decade of life when fatty tissue accumulates. Histologically, lipoma is composed of mature fat cells with a thin fibrous capsule. Simple lipomas account for 80% of adipose tissue tumours. The aetiology may be genetic like Familial Multiple Lipomatosis. Some tumours, like the well differentiated Liposarcomas never metastasize unless they undergo de-differentiation. They can be introduced as Atypical Lipomatous Tissue, ALT. Southern blot analysis is performed by obtaining DNA from ALT, cases in which most of them are characterized by the presence of supernumerary ring and long marker chromosomes. The complex chromosome region contains genes MDM2, CDK4, HMGI- C, SAS, GLI, CHOP, OS4 and OSP. Most of ALTs, after analysis revealed amplification of CDK4 and MDM2 proto- oncogenes that play major role in permitting over ride of block operated on cell proliferation.  Immuno-histochemical results have shown MDM2 over expression in about 50% of ALTs along with weak CDK4 immuno-positivity. Also the lipomas with Gene fusion transcripts have the expression of certain genes, HMGA2/LPP, HMGA2/RDCI and HMGA2/NFIB. Of these 98% of cases were analyzed for the possible expression of HMGA2/LPP and LPP- HMGA2 fusion genes using reverse transcription polymerase chain reaction. Over all these cases, shows non-enhanced adipocyte apoptosis and enhanced adipogenesis in lipoma tissue. Thus studies provide insights into molecular pathogenesis of lipomatous tumour and representation of distinctive subset of mesenchymal neoplasms with mature adipocyte differentiation.

Atypical lipomatous tumour (lipoma-like well-differentiated liposarcoma) arising in a pulmonary hamartoma and clinically presenting with pneumothorax

Lung Cancer ◽  
2003 ◽  
Vol 39 (1) ◽  
pp. 103-106 ◽  
Author(s):  
Giulio Rossi ◽  
Alberto Cavazza ◽  
Riccardo Valli ◽  
Pietro Torricelli ◽  
Luca Richeldi ◽  
...  
Keyword(s):  
Lipomatous Tumour ◽  
Pulmonary Hamartoma ◽  
Well Differentiated

scholarly journals An Association of Multiple Well Differentiated Liposarcomas, Lipomatous Tissue and Hereditary Retinoblastoma

Sarcoma ◽  
2005 ◽  
Vol 9 (3-4) ◽  
pp. 151-156 ◽  
Author(s):  
J. K. O'Neill ◽  
C. A. Stone ◽  
P. Sarsfield ◽  
M. Smith ◽  
S. F. Smithson ◽  
...  
Keyword(s):  
Surgical Management ◽  
Metastatic Potential ◽  
Upper Extremities ◽  
Low Grade ◽  
Retinoblastoma Gene ◽  
Marginal Excision ◽  
Lipomatous Tumour ◽  
Well Differentiated ◽  
Grade Tumour

Well differentiated liposarcoma (atypical lipomatous tumour) is a low grade tumour, with no metastatic potential unless dedifferentiation supervenes. When superficial, it recurs locally only occasionally after marginal excision. We present a patient in whom bilateral childhood retinoblastoma was followed by later development of massive confluent areas of low grade liposarcoma and lipomatous tissue affecting the upper extremities and trunk. We discuss the role of mutations in the retinoblastoma gene (RB1) in linking these conditions and demonstrate the surgical management of an extremely unusual and challenging case.

Sign in / Sign up

Export Citation Format

Share Document